Tourism of a different kind in God\u27s own country : a critical hermeneutic exploration of socioeconomic development in Kerala, India

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Externalizing the Duty: A Cause of Action Where Crown Failure to Consult First Nations Results in Third Party Loss

The decision-making process underlying Crown authorization of natural resource industry activity may trigger an obligation on the part of the Crown to consult First Nations. Consultation must accord with constitutional standards. Non-compliance can result in restriction of previously authorized third party undertakings. This can be costly and harmful to the industry. This paper assesses the prospects of a cause of action against the Crown in negligence as a potential avenue of compensation for third parties who suffer loss as a result of inadequate Crown consultation. The analysis incorporates relevant facts from several recent cases regarding ‘Haida motions’ and concludes that, in certain circumstances, such an action could succeed

Increasing the frequency of hand washing by healthcare workers does not lead to commensurate reductions in staphylococcal infection in a hospital ward

Hand hygiene is generally considered to be the most important measure that can be applied to prevent the spread of healthcare-associated infection (HAI). Continuous emphasis on this intervention has lead to the widespread opinion that HAI rates can be greatly reduced by increased hand hygiene compliance alone. However, this assumes that the effectiveness of hand hygiene is not constrained by other factors and that improved compliance in excess of a given level, in itself, will result in a commensurate reduction in the incidence of HAI. However, several researchers have found the law of diminishing returns to apply to hand hygiene, with the greatest benefits occurring in the first 20% or so of compliance, and others have demonstrated that poor cohorting of nursing staff profoundly influences the effectiveness of hand hygiene measures. Collectively, these findings raise intriguing questions about the extent to which increasing compliance alone can further reduce rates of HAI. In order to investigate these issues further, we constructed a deterministic Ross-Macdonald model and applied it to a hypothetical general medical ward. In this model the transmission of staphylococcal infection was assumed to occur after contact with the transiently colonized hands of HCWs, who, in turn, acquire contamination only by touching colonized patients. The aim of the study was to evaluate the impact of imperfect hand cleansing on the transmission of staphylococcal infection and to identify, whether there is a limit, above which further hand hygiene compliance is unlikely to be of benefit. The model demonstrated that if transmission is solely via the hands of HCWs, it should, under most circumstances, be possible to prevent outbreaks of staphylococcal infection from occurring at a hand cleansing frequencies <50%, even with imperfect hand hygiene. The analysis also indicated that the relationship between hand cleansing efficacy and frequency is not linear - as efficacy decreases, so the hand cleansing frequency required to ensure R0<1 increases disproportionately. Although our study confirmed hand hygiene to be an effective control measure, it demonstrated that the law of diminishing returns applies, with the greatest benefit derived from the first 20% or so of compliance. Indeed, our analysis suggests that there is little benefit to be accrued from very high levels of hand cleansing and that in most situations compliance >40% should be enough to prevent outbreaks of staphylococcal infection occurring, if transmission is solely via the hands of HCWs. Furthermore we identified a non-linear relationship between hand cleansing efficacy and frequency, suggesting that it is important to maximise the efficacy of the hand cleansing process

Evolution of inclined planets in three-dimensional radiative discs

While planets in the solar system only have a low inclination with respect to the ecliptic there is mounting evidence that in extrasolar systems the inclination can be very high, at least for close-in planets. One process to alter the inclination of a planet is through planet-disc interactions. Recent simulations considering radiative transport have shown that the evolution of migration and eccentricity can strongly depend on the thermodynamic state of the disc. We extend previous studies to investigate the planet-disc interactions of fixed and moving planets on inclined and eccentric orbits. We also analyse the effect of the disc's thermodynamic properties on the orbital evolution of embedded planets in detail. The protoplanetary disc is modelled as a viscous gas where the internally produced dissipation is transported by radiation. For locally isothermal discs, we confirm previous results and find inclination damping and inward migration for planetary cores. For low inclinations i < 2 H/r, the damping is exponential, while di/dt is proportional to i^-2 for larger i. For radiative discs, the planetary migration is very limited, as long as their inclination exceeds a certain threshold. If the inclination is damped below this threshold, planetary cores with a mass up to approximately 33 Earth masses start to migrate outwards, while larger cores migrate inwards right from the start. The inclination is damped for all analysed planet masses. In a viscous disc an initial inclination of embedded planets will be damped for all planet masses. This damping occurs on timescales that are shorter than the migration time. If the inclination lies beneath a certain threshold, the outward migration in radiative discs is not handicapped. Outward migration is strongest for circular and non-inclined orbits

Accreting Protoplanets in the LkCa 15 Transition Disk

Exoplanet detections have revolutionized astronomy, offering new insights into solar system architecture and planet demographics. While nearly 1900 exoplanets have now been discovered and confirmed, none are still in the process of formation. Transition discs, protoplanetary disks with inner clearings best explained by the influence of accreting planets, are natural laboratories for the study of planet formation. Some transition discs show evidence for the presence of young planets in the form of disc asymmetries or infrared sources detected within their clearings, as in the case of LkCa 15. Attempts to observe directly signatures of accretion onto protoplanets have hitherto proven unsuccessful. Here we report adaptive optics observations of LkCa 15 that probe within the disc clearing. With accurate source positions over multiple epochs spanning 2009 - 2015, we infer the presence of multiple companions on Keplerian orbits. We directly detect H{\alpha} emission from the innermost companion, LkCa 15 b, evincing hot (~10,000 K) gas falling deep into the potential well of an accreting protoplanet.Comment: 35 pages, 3 figures, 1 table, 9 extended data item

Range of outward migration and influence of the disc's mass on the migration of giant planet cores

The migration of planets plays an important role in the early planet-formation process. An important problem has been that standard migration theories predict very rapid inward migration, which poses problems for population synthesis models. However, it has been shown recently that low-mass planets (20-30 Earth Masses) that are still embedded in the protoplanetary disc can migrate outwards under certain conditions. Simulations have been performed mostly for planets at given radii for a particular disc model. Here, we plan to extend previous work and consider different masses of the disc to quantify the influence of the physical disc conditions on planetary migration. We perform three-dimensional (3D) radiation hydrodynamical simulations of embedded planets in protoplanteary discs. For planets on circular orbits at various locations we measure the radial dependece of the torques. For all considered planet masses (20-30 Earth masses) in this study we find outward migration within a limited radial range of the disc, typically from about 0.5 up to 1.5-2.5 a_Jup. Inside and outside this intervall, migration is inward and given by the Lindblad value for large radii. Because outward migration stops at a certain location in the disc, there exists a zero-torque distance for planetary embryos, where they can continue to grow without moving too fast. For higher disc masses (M_disc > 0.02 M_Sol) convection ensues, which changes the structure of the disc and therefore the torque on the planet as well. Outward migration stops at different points in the disc for different planetary masses, resulting in a quite extended region where the formation of larger cores might be easier. In higher mass discs, convection changes the disc's structure resulting in fluctuations in the surface density, which influence the torque acting on the planet, and therefore its migration rate

Outward migration of a giant planet with a gravitationally unstable gap edge

We present numerical simulations of disc-planet interactions where the planet opens a gravitationally unstable gap in an otherwise gravitationally stable disc. In our disc models, where the outer gap edge can be unstable to global spiral modes, we find that as we increase the surface density scale the gap becomes more unstable and the planet migrates outwards more rapidly. We show that the positive torque is provided by material brought into the planet's coorbital region by the spiral arms. This material is expected to execute horseshoe turns upon approaching the planet and hence torque it. Our results suggest that standard type II migration, applicable to giant planets in non-self-gravitating viscous discs, is likely to be significantly modified in massive discs when gravitational instabilities associated with the gap occur.Comment: 9 pages, 11 figures, accepted by MNRA

Spatially resolved submm imaging of the HR 8799 debris disk

Dynamical interactions between planets and debris disks may sculpt the disk structure and impact planetary orbits, but only a few systems with both imaged planets and spatially resolved debris disks are known. With the Caltech Submm Observatory (CSO), we have observed the HR 8799 debris disk at 350{\mu}m. The 350{\mu}m map is the first spatially resolved measurement of the debris disk encircling the HR 8799 planetary system at this wavelength. Both the flux and size of the emission are consistent with a Kuiper belt of dust extending from ~100-300 AU. Although the resolution of the current map is limited, the map shows an indication of offset asymmetric emission, and several scenarios for this possibility are explored with radiative transfer calculations of a star-disk system and N-body numerical simulations of planet-disk interactions with parameters representative of the HR 8799 system.Comment: 5 pages, 4 figures, Accepted for publication in Astronomy and Astrophysic

Monitoring Voltage-Dependent Charge Displacement of Shaker B-IR K+ Ion Channels Using Radio Frequency Interrogation

Here we introduce a new technique that probes voltage-dependent charge displacements of excitable membrane-bound proteins using extracellularly applied radio frequency (RF, 500 kHz) electric fields. Xenopus oocytes were used as a model cell for these experiments, and were injected with cRNA encoding Shaker B-IR (ShB-IR) K+ ion channels to express large densities of this protein in the oocyte membranes. Two-electrode voltage clamp (TEVC) was applied to command whole-cell membrane potential and to measure channel-dependent membrane currents. Simultaneously, RF electric fields were applied to perturb the membrane potential about the TEVC level and to measure voltage-dependent RF displacement currents. ShB-IR expressing oocytes showed significantly larger changes in RF displacement currents upon membrane depolarization than control oocytes. Voltage-dependent changes in RF displacement currents further increased in ShB-IR expressing oocytes after ∼120 µM Cu2+ addition to the external bath. Cu2+ is known to bind to the ShB-IR ion channel and inhibit Shaker K+ conductance, indicating that changes in the RF displacement current reported here were associated with RF vibration of the Cu2+-linked mobile domain of the ShB-IR protein. Results demonstrate the use of extracellular RF electrodes to interrogate voltage-dependent movement of charged mobile protein domains — capabilities that might enable detection of small changes in charge distribution associated with integral membrane protein conformation and/or drug–protein interactions