Peran Keluarga, Masyarakat Dan Media Sebagai Sumber Informasi Kesehatan Reproduksi Pada Mahasiswa

Latar Belakang: Banyak permasalahan kesehatan yang dialami oleh remaja seperti seks bebas, minum minuman keras dan penggunaan obat-obatan terlarang. Berbagai faktor yang melatarbelakangi kasus tersebut seperti pengetahuan, pola asuh orang tua, paparan media cetak dan elektronik. Tujuan: Untuk mengetahui gambaran peran keluarga, masyarakat dan media dalam menyediakan informasi mengenai kesehatan reproduksi pada mahasiswa FKIK UIN Jakarta Metode: Penelitian ini menggunakan desain cross sectional dengan pendekatan kuantitatif. Sampel adalah mahasiswa FKIK UIN Jakarta dengan jumlah 136 responden. Hasil: Responden melakukan konsultasi mengenai kesehatan reproduksi kepada teman, ibu, bapak, saudara kandung, keluarga, petugas kesehatan, pemuka agama dan guru atau dosen. Mayoritas responden menanyakan hal tersebut kepada teman dibanding dengan yang lain. Sebanyak 40,4 persen responden telah mengunjungi pertemuan masarakat mengenai kesehatan reproduksi.Dari seluruh responden, hanya21 responden (15,4%) yang tahu mengenai organisasi yang fokus pada kesehatan reproduksi, 14responden (10,3%) tahu keberadaan organisasi dan 6responden (4,4%) yang telah mengunjunginya. Penyebaran informasi mengenai kesehatan reproduksi juga terdapat pada media cetak maupun elektronik.Namun hanya sedikit responden yang memanfaatkan. Kesimpulan: Terdapat peran keluarga, masyarakat dan media dalam penyediaan informasi kesehatan reproduksi walaupun peran teman lebih dominan daripada informan lainnya

Assessment of Nutrition Information System Using Health Metrics Network Framework

Nutrition Information System (NIS) developed by Heath Ministry's Nutritional Development Directorate since 2011 covers data of toddler assessment in integrated health care, malnutrition case, coverages of Fe tablet among pregnant mothers, iodized salt consumption, vitamin A distribution and exclusive breastfeeding. This study aimed to assess NIS performance in South Tangerang City Health Agency using WHO's Health Metrics Network 2008 framework. NIS is national level information system with gradual reporting mechanism starting from 508 districts/cities to 34 provinces ended at national level. Eight districts/cities over Banten Province have conducted NIS. This study had six informants namely nutrition section, health resources and health information system section, two nutrition duties and two integrated health care workers. Data was collected on January - April 2013 using interview, observation and document analysis guidelines. Data analysis used interpretation analysis. The result showed no any policy and training implemented regarding nutrition surveillance. Monitoring activity was already conducted. Facilities were adequate, but the maintenance was deficient. There are six nutritional development indicators according to MDGs. Data grouping and dictionaries were available. Data reporting was conducted every month. Graphics and maps were used for presenting data. The data served was used for monitoring and making a decision on nutritional development programs at integrated health care, primary health care and health agency levels. Generally, NIS implementation in South Tangerang City. Health agency was already adequate

Integrative network analysis identified key genes and pathways in the progression of hepatitis C virus induced hepatocellular carcinoma

Background: Incidence of hepatitis C virus (HCV) induced hepatocellular carcinoma (HCC) has been increasing in the United States and Europe during recent years. Although HCV-associated HCC shares many pathological characteristics with other types of HCC, its molecular mechanisms of progression remain elusive. Methods: To investigate the underlying pathology, we developed a systematic approach to identify deregulated biological networks in HCC by integrating gene expression profiles with high-throughput protein-protein interaction data. We examined five stages including normal (control) liver, cirrhotic liver, dysplasia, early HCC and advanced HCC. Results: Among the five consecutive pathological stages, we identified four networks including precancerous networks (Normal-Cirrhosis and Cirrhosis-Dysplasia) and cancerous networks (Dysplasia-Early HCC, Early-Advanced HCC). We found little overlap between precancerous and cancerous networks, opposite to a substantial overlap within precancerous or cancerous networks. We further found that the hub proteins interacted with HCV proteins, suggesting direct interventions of these networks by the virus. The functional annotation of each network demonstrates a high degree of consistency with current knowledge in HCC. By assembling these functions into a module map, we could depict the stepwise biological functions that are deregulated in HCV-induced hepatocarcinogenesis. Additionally, these networks enable us to identify important genes and pathways by developmental stage, such as LCK signalling pathways in cirrhosis, MMP genes and TIMP genes in dysplastic liver, and CDC2-mediated cell cycle signalling in early and advanced HCC. CDC2 (alternative symbol CDK1), a cell cycle regulatory gene, is particularly interesting due to its topological position in temporally deregulated networks. Conclusions: Our study uncovers a temporal spectrum of functional deregulation and prioritizes key genes and pathways in the progression of HCV induced HCC. These findings present a wealth of information for further investigation

Diverse exact solutions to Davey–Stewartson model using modified extended mapping method

In this study, we obtain solitary wave solutions and other exact wave solutions for Davey–Stewartson equation (DSE), which explains how waves move through water with a finite depth while being affected by gravity and surface tension. The study is conducted with the aid of the modified extended mapping method (MEMM). A variety of distinct traveling wave solutions are furnished. The obtained solutions comprise dark, bright, and singular solitary wave solutions. Additionally, Jacobi elliptic function solutions, exponential wave solutions, singular periodic wave solutions, rational wave solutions, and periodic wave solutions are also offered. To help readers physically grasp the acquired solutions, graphical representations of some of the extracted solutions are provided

Glycerol monooleate/solvents systems for progesterone transdermal delivery: In vitro permeation and microscopic studies

A liberação transdérmica de muitos fármacos é dificultada pelas características de barreira do estrato córneo. Promotores químicos de absorção cutânea são capazes de interagir com os constituintes do estrato córneo, induzindo aumento temporário e reversível na permeabilidade da pele. O objetivo deste trabalho foi avaliar a influência de sistemas monoleína (monoleato de glicerol)/solventes na absorção percutânea de um fármaco lipofílico (a progesterona), através do estrato córneo de camundongos sem pelo, bem como o efeito da monoleína nas características estruturais do estrato córneo, por meio de microscopia eletrônica de varredura (SEM) e microscopia de varredura confocal a laser (CLSM). As alterações morfológicas observadas no estrato córneo de camundongos sem pelo sugerem efeito da monoleína na barreira da pele. E, ainda, o aumento no fluxo In vitro da progesterona, bem como na penetração in vivo do marcador fluorescente (fluoresceína), apontam a monoleína como potencial promotor de absorção cutânea. Os resultados obtidos mostraram que os sistemas monoleína/solventes provocaram alterações na estrutura do estrato córneo, que poderiam causar o aumento da permeação da progesterona através da pele de camundongos sem pelo, otimizando, deste modo, a liberação transdérmica deste fármaco.Transdermal delivery of most drugs is precluded by the barrier characteristics of the stratum corneum (SC). Chemical penetration enhancers are capable of interacting with SC constituents, inducing a temporary reversible increase in the skin permeability. The aim of this work was to assess the influence of glycerol monooleate (GMO)/solvents systems on percutaneous absorption across hairless mouse SC of a lipophilic drug, progesterone (PG), as well as its effect on the SC structural characteristics, by scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). The morphological changes observed in the hairless mouse SC suggest a GMO effect on the skin barrier. In addition, the increase in the In vitro PG flux and in vivo penetration of a fluorescent label point towards GMO as a potential absorption enhancer. The results obtained showed that GMO/solvents systems provoked changes in the SC that could be causing increased permeation of PG across hairless mouse skin, optimising in this way the transdermal delivery of this drug

Vulnerability of Brazilian municipalities to hantavirus infections based on multi‑criteria decision analysis

Background: Hantavirus infection is an emerging zoonosis transmitted by wild rodents. In Brazil, high case-fatality rates among humans infected with hantavirus are of serious concern to public health authorities. Appropriate preventive measures partly depend on reliable knowledge about the geographical distribution of this disease. Methods: Incidence of hantavirus infections in Brazil (1993–2013) was analyzed. Epidemiological, socioeconomic, and demographic indicators were also used to classify cities’ vulnerability to disease by means of multi-criteria decision analysis (MCDA). Results: From 1993 to 2013, 1752 cases of hantavirus were registered in 16 Brazilian states. The highest incidence of hantavirus was observed in the states of Mato Grosso (0.57/100,000) and Santa Catarina (0.13/100,000). Based on MCDA analysis, municipalities in the southern, southeastern, and midwestern regions of Brazil can be classified as highly vulnerable. Most municipalities in northern and northeastern Brazil were classified as having low vulnerability to hantavirus cardiopulmonary syndrome. Conclusions: Although most human infections by hantavirus registered in Brazil occurred in the southern region of the country, a greater vulnerability to hantavirus was found in the Brazilian Midwest. This result reflects the need to strengthen surveillance where the disease has thus far gone unreported

Solitons in magneto-optic waveguides with Kudryashov’s law nonlinear refractive index for coupled system of generalized nonlinear Schrödinger’s equation using modified extended mapping method

In this work, we investigate the optical solitons and other waves through magneto-optic waveguides with Kudryashov’s law of nonlinear refractive index in the presence of chromatic dispersion and Hamiltonian-type perturbation factors using the modified extended mapping approach. Many classifications of solutions are established like bright solitons, dark solitons, singular solitons, singular periodic wave solutions, exponential wave solutions, rational wave, solutions, Weierstrass elliptic doubly periodic solutions, and Jacobi elliptic function solutions. Some of the extracted solutions are described graphically to provide their physical understanding of the acquired solutions

Chemical Kinetic Insights into the Octane Number and Octane Sensitivity of Gasoline Surrogate Mixtures

Gasoline octane number is a significant empirical parameter for the optimization and development of internal combustion engines capable of resisting knock. Although extensive databases and blending rules to estimate the octane numbers of mixtures have been developed and the effects of molecular structure on autoignition properties are somewhat understood, a comprehensive theoretical chemistry-based foundation for blending effects of fuels on engine operations is still to be developed. In this study, we present models that correlate the research octane number (RON) and motor octane number (MON) with simulated homogeneous gas-phase ignition delay times of stoichiometric fuel/air mixtures. These correlations attempt to bridge the gap between the fundamental autoignition behavior of the fuel (e.g., its chemistry and how reactivity changes with temperature and pressure) and engine properties such as its knocking behavior in a cooperative fuels research (CFR) engine. The study encompasses a total of 79 hydrocarbon gasoline surrogate mixtures including 11 primary reference fuels (PRF), 43 toluene primary reference fuels (TPRF), and 19 multicomponent (MC) surrogate mixtures. In addition to TPRF mixture components of iso-octane/n-heptane/toluene, MC mixtures, including n-heptane, iso-octane, toluene, 1-hexene, and 1,2,4-trimethylbenzene, were blended and tested to mimic real gasoline sensitivity. ASTM testing protocols D-2699 and D-2700 were used to measure the RON and MON of the MC mixtures in a CFR engine, while the PRF and TPRF mixtures' octane ratings were obtained from the literature. The mixtures cover a RON range of 0-100, with the majority being in the 70-100 range. A parametric simulation study across a temperature range of 650-950 K and pressure range of 15-50 bar was carried out in a constant-volume homogeneous batch reactor to calculate chemical kinetic ignition delay times. Regression tools were utilized to find the conditions at which RON and MON best correlate with simulated ignition delay times. Furthermore, temperature and pressure dependences were investigated for fuels with varying octane sensitivity. This analysis led to the formulation of correlations useful to the definition of surrogates for modeling purposes and allowed one to identify conditions for a more in-depth understanding of the chemical phenomena controlling the antiknock behavior of the fuels

New soliton wave structure and modulation instability analysis for nonlinear Schrödinger equation with cubic, quintic, septic, and nonic nonlinearities

We have introduced various novel soliton waves and other analytic wave solutions for nonlinear Schrödinger equation with cubic, quintic, septic, and nonic nonlinearities. The modified extended direct algebraic method governs the transmission of various solitons with different effects. The combination of this system enables the obtaining of analytical soliton solutions with some unique behaviors, including bright, dark, and mixed dark-bright soliton solutions; singular soliton solutions; singular periodic, exponential, rational wave solutions; and Jacobi elliptic function solutions. These results realize the stability of the nonlinear waves' propagation in a high-nonlinear-dispersion medium that is illustrated using 2D and 3D visuals and contour graphical diagrams of the output solutions. This research focused on determining exact soliton solutions under certain parameter conditions and evaluating the stability and reliability of the soliton solutions based on the used modified extended direct algebraic method. This will be useful for many various domains in technology and physics, such as biology, optics, and plasma physical science. At the end, we use modulation instability analysis to assess the stability of the wave solutions obtained