Casimir Energy and Entropy between perfect metal Spheres

We calculate the Casimir energy and entropy for two perfect metal spheres in the large and short separation limit. We obtain nonmonotonic behavior of the Helmholtz free energy with separation and temperature, leading to parameter ranges with negative entropy, and also nonmonotonic behavior of the entropy with temperature and with the separation between the spheres. The appearance of this anomalous behavior of the entropy is discussed as well as its thermodynamic consequences.Comment: 10 pages and 8 figures. Accepted for publication in the Proceedings of the tenth conference on Quantum Field Theory under the influence of external conditions - QFEXT'1

Stochastic Quantization and Casimir Forces: Pistons of Arbitrary Cross Section

Recently, a method based on stochastic quantization has been proposed to compute the Casimir force and its fluctuations in arbitrary geometries. It relies on the spectral decomposition of the Laplacian operator in the given geometry. Both quantum and thermal fluctuations are considered. Here we use such method to compute the Casimir force on the plates of a finite piston of arbitrary cross section. Asymptotic expressions valid at low and high temperatures and short and long distances are obtained. The case of a piston with triangular cross section is analysed in detail. The regularization of the divergent stress tensor is described.Comment: 10 pages and 4 figures. Accepted for publication in the Proceedings of the tenth conference on Quantum Field Theory under the influence of external conditions - QFEXT'1

Successful ageing in an area of deprivation: Part 1—A qualitative exploration of the role of life experiences in good health in old age

Objectives: To determine the life histories and current circumstances of healthy and unhealthy older people who share an ecology marked by relative deprivation and generally poor health. Study design: In-depth interview study with a qualitative analysis. Methods: Matched pairs of healthy and unhealthy ‘agers’ were interviewed face-to-face. Healthy ageing was assessed in terms of hospital morbidity and self-reported health. Study participants consisted of 22 pairs (44 individuals), aged 72–89 years, matched for sex, age and deprivation category, and currently resident in the West of Scotland. All study participants were survivors of the Paisley/Renfrew (MIDSPAN) survey, a longitudinal study commenced in 1972 with continuous recording of morbidity and mortality since. Detailed life histories were obtained which focused on family, residence, employment, leisure and health. This information was supplemented by more focused data on ‘critical incidents’, financial situation and position in social hierarchies. Results: Data provided rich insights into life histories and current circumstances but no differences were found between healthy and unhealthy agers. Conclusions: It is important to understand what differentiates individuals who have lived in circumstances characterized by relative deprivation and poor health, yet have aged healthily. This study collected rich and detailed qualitative data. Yet, no important differences were detected between healthy and unhealthy agers. This is an important negative result as it suggests that the phenomenon of healthy ageing and the factors that promote healthy ageing over a lifetime are so complex that they will require even more detailed studies to disentangle

Factors governing macrozoobenthic assemblages in perennial springs in north-western Switzerland

Springs are important freshwater habitats that provide refuge for many rare species. In this study, the fauna and abiotic parameters of 20 perennial springs in north-western Switzerland were investigated. Correlation of abiotic and macrozoobenthos data showed that physicochemical parameters had little impact on macrozoobenthic composition, whereas specific substrate parameters strongly influenced the composition of the macrofauna. Surprisingly, nonmetric multidimensional scaling did not reveal a grouping of springs with similar substrate composition or macrozoobenthic assemblages. However, discharge was identified as the factor significantly determining substrate and the composition of macroinvertebrate assemblages. This justifies the hypothesis that, variation in discharge is the disturbance factor governing the macrofaunal composition temporally and spatially within and between patche

The Generation of Successive Unmarked Mutations and Chromosomal Insertion of Heterologous Genes in Actinobacillus pleuropneumoniae Using Natural Transformation

We have developed a simple method of generating scarless, unmarked mutations in Actinobacillus pleuropneumoniae by exploiting the ability of this bacterium to undergo natural transformation, and with no need to introduce plasmids encoding recombinases or resolvases. This method involves two successive rounds of natural transformation using linear DNA: the first introduces a cassette carrying cat (which allows selection by chloramphenicol) and sacB (which allows counter-selection using sucrose) flanked by sequences to either side of the target gene; the second transformation utilises the flanking sequences ligated directly to each other in order to remove the cat-sacB cassette. In order to ensure efficient uptake of the target DNA during transformation, A. pleuropneumoniae uptake sequences are added into the constructs used in both rounds of transformation. This method can be used to generate multiple successive deletions and can also be used to introduce targeted point mutations or insertions of heterologous genes into the A. pleuropneumoniae chromosome for development of live attenuated vaccine strains. So far, we have applied this method to highly transformable isolates of serovars 8 (MIDG2331), which is the most prevalent in the UK, and 15 (HS143). By screening clinical isolates of other serovars, it should be possible to identify other amenable strains

Conceptual mechanization studies for a horizon definition spacecraft electrical power subsystem

Solar cell-battery electrical power subsystem for horizon definition spacecraf

Attractive Casimir Forces in a Closed Geometry

We study the Casimir force acting on a conducting piston with arbitrary cross section. We find the exact solution for a rectangular cross section and the first three terms in the asymptotic expansion for small height to width ratio when the cross section is arbitrary. Though weakened by the presence of the walls, the Casimir force turns out to be always attractive. Claims of repulsive Casimir forces for related configurations, like the cube, are invalidated by cutoff dependence.Comment: An updated version to coincide with the one published December 2005 in PRL. 4 pages, 2 figure

The Efficacy of Paroxetine and Placebo in Treating Anxiety and Depression: A Meta-Analysis of Change on the Hamilton Rating Scales

Background: Previous meta-analyses of published and unpublished trials indicate that antidepressants provide modest benefits compared to placebo in the treatment of depression; some have argued that these benefits are not clinically significant. However, these meta-analyses were based only on trials submitted for the initial FDA approval of the medication and were limited to those aimed at treating depression. Here, for the first time, we assess the efficacy of a selective serotonin reuptake inhibitor (SSRI) in the treatment of both anxiety and depression, using a complete data set of all published and unpublished trials sponsored by the manufacturer. Methods and Findings: GlaxoSmithKline has been required to post the results for all sponsored clinical trials online, providing an opportunity to assess the efficacy of an SSRI (paroxetine) with a complete data set of all trials conducted. We examined the data from all placebo-controlled, double-blind trials of paroxetine that included change scores on the Hamilton Rating Scale for Anxiety (HRSA) and/or the Hamilton Rating Scale for Depression (HRSD). For the treatment of anxiety (k = 12), the efficacy difference between paroxetine and placebo was modest (d = 0.27), and independent of baseline severity of anxiety. Overall change in placebo-treated individuals replicated 79% of the magnitude of paroxetine response. Efficacy was superior for the treatment of panic disorder (d = 0.36) than for generalized anxiety disorder (d = 0.20). Published trials showed significantly larger drug-placebo differences than unpublished trials (d’s = 0.32 and 0.17, respectively). In depression trials (k = 27), the benefit of paroxetine over placebo was consistent with previous meta-analyses of antidepressant efficacy (d = 0.32). Conclusions: The available empirical evidence indicates that paroxetine provides only a modest advantage over placebo in treatment of anxiety and depression. Treatment implications are discussed

Expanded boundary integral method and chaotic time-reversal doublets in quantum billiards

We present the expanded boundary integral method for solving the planar Helmholtz problem, which combines the ideas of the boundary integral method and the scaling method and is applicable to arbitrary shapes. We apply the method to a chaotic billiard with unidirectional transport, where we demonstrate existence of doublets of chaotic eigenstates, which are quasi-degenerate due to time-reversal symmetry, and a very particular level spacing distribution that attains a chaotic Shnirelman peak at short energy ranges and exhibits GUE-like statistics for large energy ranges. We show that, as a consequence of such particular level statistics or algebraic tunneling between disjoint chaotic components connected by time-reversal operation, the system exhibits quantum current reversals.Comment: 18 pages, 8 figures, with 3 additional GIF animations available at http://chaos.fiz.uni-lj.si/~veble/boundary