Features of psychological well-being and success among young mothers

Background.Understanding the internal resources of women during the transition to motherhood is essential for developing effective psychological support programs and preventing emotional disturbances. The early stages of motherhood are characterized by significant life changes and intense emotional stress, making it particularly important to explore the factors that determine a woman's psychological well-being. However, aspects such as life meaning and personal fulfillment among young mothers remain insufficiently studied in the scientific literature. Purpose.To identify the personal and existential foundations of subjective well-being in women during early motherhood. Materials and methods. The study involved 120 women aged 25–35 who were legally married and raising one child under the age of one. Validated questionnaires developed by C. Ryff and D.A. Leontiev were used. Statistical data analysis was carried out using Spearman’s correlation analysis. Results. A high level of life goals was revealed, giving young mothers a sense of perspective and direction. A reduced perception of freedom of choice and relative dissatisfaction with their current life situation were also identified. The main predictors of subjective well-being were found to be self-acceptance, autonomy, and purposefulness, with self-acceptance having the strongest impact on the overall level of well-being. A significant correlation was established between environmental mastery and all major components of personal potential. The level of autonomy was determined by the ability for self-regulation and independence. Positive relations with others were not directly associated with autonomy but were mediated by life goals and self-acceptance. The psychological well-being of young mothers is thus seen as the result of the complex realization of personal resources

Disinfectant properties of slaked lime with sodium chloride

The search of new disinfectants with a wide spectrum of antimicrobial activity of low toxicity and not hazardous in use, not requiring of creation of special storage conditions, convenient in use and not adversely affecting on processed items, affordable, is an urgent task of veterinary science. The article presents the results of laboratory tests of new bactericidal compositions, which include: 20% hydrated lime, 1.3 and 5% sodium chloride, as well as foaming agent PO-6K on test surfaces made of stainless steel, galvanized gland, tile, wood and concrete. As a test of microorganisms, museum cultures of E. coli (strain 1257) and Staphylococcus aureus (strain 209-P) were used. During the experiments, disinfection regimes were established (concentration, exposure, consumption of disinfectant) for disinfecting of smooth and rough test surfaces. At the same time, it was found that slaked lime solutions of 10 and 15% concentration did not have disinfecting activity even after triple whitening or irrigation of test surfaces contaminated with E. ooli (strain 1257), St. aureus (strain 209-P) at a rate of 0,5 l/m2 for smooth and 1 l/m2 - for rough surfaces. 20% solution of slaked lime, which destroys only Escherichia coli on smooth surfaces in 3 hours of exposure at the rate of 0,5 l/m2, and rough surfaces in 24 hours of exposure at the rate of 1,0 l/m2, has a disinfecting effect. At the same time, adding 1,3 and 5% sodium chloride to the slaked lime solution, the disinfecting activity of slaked lime also increases sharply; adding to 20% slaked lime 3 and 5% sodium chloride disinfects Escherichia coli and staphylococcus in 3 hours, based on smooth 0,5 l/m2, and for rough surfaces - 1 l/m2. Studies have also found that the addition of 3-5% sodium chloride, 5% foaming agent to 20% slaked lime solution reduces the consumption of the disinfectant in 2 times without reflecting the indicators of disinfection efficiency. When a foaming agent is added to the solution, the resistance (adhesion) of the foam on the vertical and ceiling surfaces increases on 14-18 minutes, and on the floor the foam is held in 1-1,5 hours, which helps to reduce the runoff of the solution.</jats:p

Comparative disinfective activity of Penox-1 and Penox-2 preparation solutions

Relevance and methodology. The results of laboratory studies of solutions of disinfectants Penox-1 and Penox-2, carried out on rough tests surfaces made of concrete, wood and metlakh tiles, against Mycobacterium (strain B-5) and Bac. cereus spores (strain 96) are presented. Experiments were carried out to establish the modes of disinfection of Penox-2 in a comparative aspect with solutions of Penox-1. For protein protection of the test cultures, horse blood serum was applied to the test surface, at the rate of 0.5 g/100 cm2. When developing disinfection modes, contaminated rough test surfaces were placed horizontally and vertically. Disinfection of the test surfaces was carried out by the method of wet disinfection, at the rate of 0.5 l/m2, at exposure 1; 3 and 24 hours. The treatment was carried out twice with an interval of 60 min. All studies were carried out in 3-fold repetition. The criterion for the effectiveness of the agent in the disinfection of surfaces is 100% death of test cultures.Results. It was found that with a single irrigation with solutions of the Penox-1 preparation, disinfection of test surfaces made of concrete, wood and metlakh tiles contaminated with mycobacteria and Bac. cereus spores was not achieved. Disinfection of the test surfaces from mycobacteria occurred with double irrigation, exposure for 24 hours, at the rate of 1 l/m2. Double irrigation of Bac. cereus spores did not result in decontamination of test surfaces. At the same time, the addition of chloramine B to the composition of the preparation Penox-2 at a concentration of 0.5–3.0% led to the disinfection of test surfaces from mycobacteria and Bac. cereus spores respectively after 1 and 3 hours, at the rate of 0.5 l/m2, with single irrigation.</jats:p

Possibilities of physiotherapy in Mayer–Rokitansky–Kuester–Hauser syndrome

BACKGROUND: MayerRokitanskyKuesterHauser syndrome occurs in 1 of 40005000 newborn girls. The first-line treatment of aplasia of the vagina is considered a vaginal dilation. The use of physiotherapy capabilities in the practice of obstetricians and gynecologists is quite widespread and has firmly established itself in clinical practice.&#x0D; AIMS: To evaluate the effectiveness and tolerability of dilation in combination and without physical effects in the formation of vagina in adolescent girls.&#x0D; MATERIALS AND METHODS: A prospective cohort study of 64 adolescent girls 15 to 18 y with a first-time diagnosis of vaginal and uterine aplasia was conducted. Their psychophysiological features were analyzed with testing according to the questionnaire well-being, activity, mood (SAN), physical and sexual development, a gynecological examination was performed to determine the depth of the vaginal fossa. Teenage girls were randomized into 2 groups: 1 (n=36) to create an artificial vagina, with the method of dilation. The second group of patients (n=28) underwent preformed physiotherapy with subsequent dilation. All the girls daily made a graph of the increase in the length of the vagina and determined the intensity of pain using a visual-analog scale (VAS). After the treatment was completed, the patients were re-tested according to the SAN method.&#x0D; RESULTS: A significant increase in the length of the neovagal space was noted in the group of complex treatment with physiotherapy already at the 8th procedure, with an increase after the completion of 20 procedures. In group 2, the dynamics of pain intensity significantly decreased in comparison with the 1st group. The psychological status of the patients according to the SAN before the start of treatment was characterized by an unfavorable state.&#x0D; CONCLUSION: Conducting course procedures of complex dilation with the use of heat-magneto-vibration in girls with vaginal aplasia has a significant reduction in pain and allowed to achieve the required anatomical length in a shorter time compared to monomethodics.</jats:p

Diagnostic and treatment of secondary chondrosarcoma of the femur with multiple recurrences. Case report

Chondrosarcoma is one of the most common tumors in adults. Resectable chondrosarcomas requires surgical treatment, and tend to local recurrence, often repeatedly.A case report of a 38 years old female patient with secondary chondrosarcoma of femur is presented. The role of multidisciplinary team in tactic choice of primary treatment and recurrence treatment is shown.</jats:p

Clinical Findings in Two patients with DSD 46XY caused by new variant of the &lt;i&gt;Desert Hedgehog&lt;/i&gt; Gene and review of the literature of the role of DHH signaling pathway in sex development

Mutations in the gene DHH are an extremely rare cause of disorders of sex development 46,XY (DSD,46XY). The article describes the clinical cases of two unrelated patients with gonadal dysgenesis 46,XY with female phenotype. By using a next generation sequencing method, in both cases the same biallelic variant substitution c. 419T&gt;G in the DHH gene was revealed. Taking into account the data on the role of DHH in the formation of the nervous system, the diagnosis of minifascicular polyneuropathy at the preclinical stage was confirmed in both cases. These cases demonstrate the value of using NGS, which allows simultaneous analysis of a wide range of candidate genes in DSD and the diagnosis of comorbidities before the development of the clinical picture. These are the first descriptions of patients with mutations in the DHH gene in the Russian population.</jats:p