Identification and evaluation of linear damping models in beam vibrations

Sensitive method, identifying effective damping mechanisms, involves comparing experimentally determined ratio of first to second mode magnification factors related to common point on beam. Cluster size has little effect on frequencies of elements, magnification factor decreases with cluster size, and viscous and stress damping are dominant damping mechanisms

Effectiveness of cognitive and physical training in slowing progression to dementia: a clinical and experimental study. Focus on relationship with cardiovascular fitness

Physical activity is beneficial to vascular health; on the other hand, vascular damage is associated with cognitive impairment. Both physical activity and a cognitively stimulating environment are known to delay the onset of dementia. The Train The Brain study evaluated the effectiveness of a comprehensive program of physical training and mental activity in delaying cognitive decline in elderly people with initial cognitive impairment, at the same time investigating the relationship between physical, vascular, neurological, and cognitive fitness. Elders age 65-89 with were recruited with the help of family physicians and territorial services. All participants underwent a neurological and cardiologic evaluation. Carotid-femoral pulse wave velocity and carotid pressure were measured with the SphygmoCor system (AtCor, Australia). Longitudinal ultrasound scans of the common carotid were performed and 10-second video clips were recorded to be analysed offline through the Cardiovascular Suite software (Quipu srl, Italy), with the computation of diameter, intima-media thickness, wall cross-sectional area, distensibility coefficient, and elastic modulus. The latter software was used also to measure endothelial function through flow mediated dilation (FMD) of the brachial artery. Subjects classified as mild cognitive impairment at the neurological examination were randomized either to standard care, or a 7-month program of physical training and environmental stimulation (lectures, games, music, social activities) three hours a week. The evaluation was then repeated. Data were obtained for 54 patients who underwent training and 36 controls. The intervention was successful in improving cognitive function as measured through the ADAS-Cog score: 11.95 (3.86) to 13.00 (4.73) for no training, 14.32 (4.27) to 12.85 (4.03) for training, time x treatment p<0.001. Pulse wave velocity showed no significant effect (p=0.5). FMD improved with intervention (no training: 3.20 (2.03) to 2.50 (1.77) %; training: from 2.82 (2.19) to 3.42 (1.82); p=0.014). All selected carotid parameters were influenced by the combination of time and treatment, in a diverging trend, at a statistically significant level, with intervention determining less dilated, less thick and less stiff vessels. None of the parameters measured analysing the vessels showed a correlation The proposed 7-months program improved cognitive function in elders with initial cognitive impairment. There was a significant difference in behaviour in time of the two groups as for endothelial function and carotid enlargement, wall thickening and arterial stiffening. The intervention seems to oppose the typical harmful effects of aging on vessels; at the same time, the positive effects on cognition and vascular health do not appear as directly correlated

Prediction of final infarct volume from native CT perfusion and treatment parameters using deep learning

CT Perfusion (CTP) imaging has gained importance in the diagnosis of acute stroke. Conventional perfusion analysis performs a deconvolution of the measurements and thresholds the perfusion parameters to determine the tissue status. We pursue a data-driven and deconvolution-free approach, where a deep neural network learns to predict the final infarct volume directly from the native CTP images and metadata such as the time parameters and treatment. This would allow clinicians to simulate various treatments and gain insight into predicted tissue status over time. We demonstrate on a multicenter dataset that our approach is able to predict the final infarct and effectively uses the metadata. An ablation study shows that using the native CTP measurements instead of the deconvolved measurements improves the prediction.Comment: Accepted for publication in Medical Image Analysi

Bragg spectroscopy of a superfluid Bose-Hubbard gas

Bragg spectroscopy is used to measure excitations of a trapped, quantum-degenerate gas of 87Rb atoms in a 3-dimensional optical lattice. The measurements are carried out over a range of optical lattice depths in the superfluid phase of the Bose-Hubbard model. For fixed wavevector, the resonant frequency of the excitation is found to decrease with increasing lattice depth. A numerical calculation of the resonant frequencies based on Bogoliubov theory shows a less steep rate of decrease than the measurements.Comment: 11 pages, 4 figure

Bose-Einstein Condensate in Weak 3d Isotropic Speckle Disorder

The effect of a weak three-dimensional (3d) isotropic laser speckle disorder on various thermodynamic properties of a dilute Bose gas is considered at zero temperature. First, we summarize the derivation of the autocorrelation function of laser speckles in 1d and 2d following the seminal work of Goodman. The goal of this discussion is to show that a Gaussian approximation of this function, proposed in some recent papers, is inconsistent with the general background of laser speckle theory. Then we propose a possible experimental realization for an isotropic 3d laser speckle potential and derive its corresponding autocorrelation function. Using a Fourier transform of that function, we calculate both condensate depletion and sound velocity of a Bose-Einstein condensate as disorder ensemble averages of such a weak laser speckle potential within a perturbative solution of the Gross-Pitaevskii equation. By doing so, we reproduce the expression of the normalfluid density obtained earlier within the treatment of Landau. This physically transparent derivation shows that condensate particles, which are scattered by disorder, form a gas of quasiparticles which is responsible for the normalfluid component

Optical Lattices: Theory

This chapter presents an overview of the properties of a Bose-Einstein condensate (BEC) trapped in a periodic potential. This system has attracted a wide interest in the last years, and a few excellent reviews of the field have already appeared in the literature (see, for instance, [1-3] and references therein). For this reason, and because of the huge amount of published results, we do not pretend here to be comprehensive, but we will be content to provide a flavor of the richness of this subject, together with some useful references. On the other hand, there are good reasons for our effort. Probably, the most significant is that BEC in periodic potentials is a truly interdisciplinary problem, with obvious connections with electrons in crystal lattices, polarons and photons in optical fibers. Moreover, the BEC experimentalists have reached such a high level of accuracy to create in the lab, so to speak, paradigmatic Hamiltonians, which were first introduced as idealized theoretical models to study, among others, dynamical instabilities or quantum phase transitions.Comment: Chapter 13 in Part VIII: "Optical Lattices" of "Emergent Nonlinear Phenomena in Bose-Einstein Condensates: Theory and Experiment," edited by P. G. Kevrekidis, D. J. Frantzeskakis, and R. Carretero-Gonzalez (Springer Series on Atomic, Optical, and Plasma Physics, 2007) - pages 247-26

Localization from quantum interference in one-dimensional disordered potentials

We show that the tails of the asymptotic density distribution of a quantum wave packet that localizes in the the presence of random or quasiperiodic disorder can be described by the diagonal term of the projection over the eingenstates of the disordered potential. This is equivalent of assuming a phase randomization of the off-diagonal/interference terms. We demonstrate these results through numerical calculations of the dynamics of ultracold atoms in the one-dimensional speckle and quasiperiodic potentials used in the recent experiments that lead to the observation of Anderson localization for matter waves [Billy et al., Nature 453, 891 (2008); Roati et al., Nature 453, 895 (2008)]. For the quasiperiodic case, we also discuss the implications of using continuos or discrete models.Comment: 5 pages, 3 figures; minor changes, references update

"An Impediment to Living Life": Why and How Should We Measure Stiffness in Polymyalgia Rheumatica?

Objectives: To explore patients’ concepts of stiffness in polymyalgia rheumatica (PMR), and how they think stiffness should be measured. Methods: Eight focus groups were held at three centres involving 50 patients with current/previous PMR. Each group had at least one facilitator and one rapporteur making field notes. An interview schedule was used to stimulate discussion. Interviews were recorded, transcribed and analysed using an inductive thematic approach. Results: Major themes identified were: symptoms: pain, stiffness and fatigue; functional impact; impact on daily schedule; and approaches to measurement. The common subtheme for the experience of stiffness was “difficulty in moving”, and usually considered as distinct from the experience of pain, albeit with a variable overlap. Some participants felt stiffness was the “overwhelming” symptom, in that it prevented them carrying out “fundamental activities” and “generally living life”. Diurnal variation in stiffness was generally described in relation to the daily schedule but was not the same as stiffness severity. Some participants suggested measuring stiffness using a numeric rating scale or a Likert scale, while others felt that it was more relevant and straightforward to measure difficulty in performing everyday activities rather than about stiffness itself. Conclusions: A conceptual model of stiffness in PMR is presented where stiffness is an important part of the patient experience and impacts on their ability to live their lives. Stiffness is closely related to function and often regarded as interchangeable with pain. From the patients’ perspective, visual analogue scales measuring pain and stiffness were not the most useful method for reporting stiffness; participants preferred numerical rating scales, or assessments of function to reflect how stiffness impacts on their daily lives. Assessing function may be a pragmatic solution to difficulties in quantifying stiffness

Difference in signalling between various hormone therapies in endometrium, myometrium and upper part of the vagina

BACKGROUND: Combined hormone treatments in post-menopausal women have different clinical responses on uterus and vagina; therefore, we investigated differences in steroid signalling between various hormone therapies in these tissues. METHODS: A total of 30 post-menopausal women scheduled for hysterectomy were distributed into four subgroups: control-group (n = 9), Tibolone-group (n = 8); estradiol (E(2))-group (n = 7); E(2) + medroxyprogesterone acetate (MPA)-group (n = 6). Medication was administered orally every day for 21 days prior to removal of uterus and upper part of the vagina. Tissue RNA was isolated, and gene expression profiles were generated using GeneChip technology and analysed by cluster analysis and significance analysis of microarrays. Apoptosis and cell proliferation assays, as well as immunohistochemistry for hormone receptors were performed. RESULTS: 21-days of treatment with E(2), E(2) + MPA or tibolone imposes clear differential gene expression profiles on endometrium and myometrium. Treatment with E(2) only results in the most pronounced effect on gene expression (up to 1493 genes differentially expressed), proliferation and apoptosis. Tibolone, potentially metabolized to both estrogenic and progestagenic metabolites, shows some resemblance to E(2) signalling in the endometrium and, in contrast, shows significant resemblance to E(2) + MPA signalling in the myometrium. In the vagina the situation is entirely different; all three hormonal treatments result in regulation of a small number (4-73) of genes, in comparison to signalling in endometrium and myometrium. CONCLUSION: Endometrium and myometrium differentially respond to the hormone therapies and use complet