Classical particle scattering for power-law two-body potentials

We present a rigorous study of the classical scattering for anytwo-body inter-particle potential of the form $v(r)=g/r^\gamma$, with\gamma\textgreater{}0, for repulsive (g\textgreater{}0) and attractive (g\textless{}0)interactions. We give a derivation of the complete power series of thedeflection angle in terms of the impact factor for the weak scatteringregime (large impact factors) as well as the asymptotic expressionsfor the hard scattering regime (small impact factors). We see a verydifferent qualitative and quantitative behavior depending whether theinteraction is repulsive or attractive. In the latter case, thefamilies of trajectories depend also strongly on the value of$\gamma$. We also study carefully the modifications of the resultswhen a regularization is introduced in the potential at small scales.We check and illustrate all the results with the exact integration ofthe equations of motion.Comment: 23 pages, 17 figure

Influence of Co layer thickness on the structural and magnetic properties of multilayers

International audienceThe correlated effects of the insertion of a Pt spacer between ferromagnetic and antiferromagnetic layers and of the variation of the Co layers thickness on the structural and magnetic properties of [ (Pt/Co tCo) 3 /Pt tPt /IrMn ] n multilayers have been studied. Samples with n = 1 and 7, t Co = 0.4 and 0.6 nm, t Pt = 0 and 0.4 nm have been investigated by tomographic atom probe and superconducting quantum interference device magnetometry. For spacer free samples (t Pt = 0), the structural investigation shows that when t Co = 0.4 nm, Mn and Ir atoms diffuse deeply in the (Pt/Co) multilayers. In contrast for t Co = 0.6 nm, the Mn and Ir diffusion is much reduced. Because Pt acts as a barrier against the Mn and Ir diffusion, this difference is less pronounced in samples with Pt insertion. The hysteresis loops shapes, the exchange bias fields and the saturation magnetization values were correlated with the structural properties of these samples and discussed, taking into account the susceptibility, exchange stiffness, and perpendicular magnetic anisotropy

Application of tandem two-dimensional mass spectrometry for top-down deep sequencing of calmodulin

Two-dimensional mass spectrometry (2DMS) involves simultaneous acquisition of the fragmentation patterns of all the analytes in a mixture by correlating their precursor and fragment ions by modulating precursor ions systematically through a fragmentation zone. Tandem two-dimensional mass spectrometry (MS/2DMS) unites the ultra-high accuracy of Fourier transform ion cyclotron resonance (FT-ICR) MS/MS and the simultaneous data-independent fragmentation of 2DMS to achieve extensive inter-residue fragmentation of entire proteins. 2DMS was recently developed for top-down proteomics (TDP), and applied to the analysis of calmodulin (CaM), reporting a cleavage coverage of about ~23% using infrared multiphoton dissociation (IRMPD) as fragmentation technique. The goal of this work is to expand the utility of top-down protein analysis using MS/2DMS in order to extend the cleavage coverage in top-down proteomics further into the interior regions of the protein. In this case, using MS/2DMS, the cleavage coverage of CaM increased from ~23% to ~42%

2D FT-ICR MS of Calmodulin : a top-down and bottom-up approach

Two-dimensional Fourier transform ion cyclotron resonance mass spectrometry (2D FT-ICR MS) allows data-independent fragmentation of all ions in a sample and correlation of fragment ions to their precursors through the modulation of precursor ion cyclotron radii prior to fragmentation. Previous results show that implementation of 2D FT-ICR MS with infrared multi-photon dissociation (IRMPD) and electron capture dissociation (ECD) has turned this method into a useful analytical tool. In this work, IRMPD tandem mass spectrometry of calmodulin (CaM) has been performed both in one-dimensional and two-dimensional FT-ICR MS using a top-down and bottom-up approach. 2D IRMPD FT-ICR MS is used to achieve extensive inter-residue bond cleavage and assignment for CaM, using its unique features for fragment identification in a less time- and sample-consuming experiment than doing the same thing using sequential MS/MS experiments

Regularity of harmonic discs in spaces with quadratic isoperimetric inequality

We study harmonic and quasi-harmonic discs in metric spaces admitting a uniformly local quadratic isoperimetric inequality for curves. The class of such metric spaces includes compact Lipschitz manifolds, metric spaces with upper or lower curvature bounds in the sense of Alexandrov, some sub-Riemannian manifolds, and many more. In this setting, we prove local Hölder continuity and continuity up to the boundary of harmonic and quasi-harmonic discs

Revisiting the B-cell compartment in mouse and humans: more than one B-cell subset exists in the marginal zone and beyond.

International audienceABSTRACT: The immunological roles of B-cells are being revealed as increasingly complex by functions that are largely beyond their commitment to differentiate into plasma cells and produce antibodies, the key molecular protagonists of innate immunity, and also by their compartmentalisation, a more recently acknowledged property of this immune cell category. For decades, B-cells have been recognised by their expression of an immunoglobulin that serves the function of an antigen receptor, which mediates intracellular signalling assisted by companion molecules. As such, B-cells were considered simple in their functioning compared to the other major type of immune cell, the T-lymphocytes, which comprise conventional T-lymphocyte subsets with seminal roles in homeostasis and pathology, and non-conventional T-lymphocyte subsets for which increasing knowledge is accumulating. Since the discovery that the B-cell family included two distinct categories - the non-conventional, or extrafollicular, B1 cells, that have mainly been characterised in the mouse; and the conventional, or lymph node type, B2 cells - plus the detailed description of the main B-cell regulator, FcγRIIb, and the function of CD40+ antigen presenting cells as committed/memory B-cells, progress in B-cell physiology has been slower than in other areas of immunology. Cellular and molecular tools have enabled the revival of innate immunity by allowing almost all aspects of cellular immunology to be re-visited. As such, B-cells were found to express "Pathogen Recognition Receptors" such as TLRs, and use them in concert with B-cell signalling during innate and adaptive immunity. An era of B-cell phenotypic and functional analysis thus began that encompassed the study of B-cell microanatomy principally in the lymph nodes, spleen and mucosae. The novel discovery of the differential localisation of B-cells with distinct phenotypes and functions revealed the compartmentalisation of B-cells. This review thus aims to describe novel findings regarding the B-cell compartments found in the mouse as a model organism, and in human physiology and pathology. It must be emphasised that some differences are noticeable between the mouse and human systems, thus increasing the complexity of B-cell compartmentalisation. Special attention will be given to the (lymph node and spleen) marginal zones, which represent major crossroads for B-cell types and functions and a challenge for understanding better the role of B-cell specificities in innate and adaptive immunology

BUILDING BRIDGES FOR INNOVATION IN AGEING : SYNERGIES BETWEEN ACTION GROUPS OF THE EIP ON AHA

The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).Peer reviewe