Development and characterization of Powder Metallurgy (PM) 2XXX series Al alloy products and Metal Matrix Composite (MMC) 2XXX Al/SiC materials for high temperature aircraft structural applications

The results of a series of material studies performed by the Lockheed Aeronautical Systems Company over the time period from 1980 to 1991 are discussed. The technical objective of these evaluations was to develop and characterize advanced aluminum alloy materials with temperature capabilities extending to 350 F. An overview is given of the first five alloy development efforts under this contract. Prior work conducted during the first five modifications of the alloy development program are listed. Recent developments based on the addition of high Zr levels to an optimum Al-Cu-Mg alloy composition by powder metallurgy processing are discussed. Both reinforced and SiC or B4C ceramic reinforced alloys were explored to achieve specific target goals for high temperature aluminum alloy applications

Effect of Coriaria arborea on seed banks during primary succession on Mt Tarawera, New Zealand

An experiment was conducted over two years to investigate the effect of Coriaria arborea, a native nitrogen-fixing shrub, on soil seed banks at sites representing a post-volcanic successional sequence on Mt Tarawera, New Zealand. The sites ranged from bare volcanic ash and lapilli substrate, through low-growing pre-Coriaria vegetation, to dense stands of Coriaria scrub. Soils (to a depth of 50 mm) under recently established Coriaria and older stands had more seedlings (1096 and 1585 seedlings 0.4 m-2, respectively) and species (37 and 45 species 0.4 m-2, respectively) emerge than where there was no Coriaria (243-320 seedlings 0.4 m-2, 14-25 species 0.4 m-2) and were the only soils with Coriaria seedlings. In total, 3488 seedlings representing 63 taxa were recorded. Seeds were still germinating after 24 months but rates declined markedly in the second year. For example, Coriaria reached a germination peak at 8 weeks but continued to germinate sporadically over the 2-year period. Tree species present in young forest within 0.5 km of the sites were absent. Establishment of Coriaria greatly accelerated an underlying trend of gradually increasing abundance and diversity of seeds in the soil with vegetation age. Adventive, wind-dispersed, and annual species were over-represented in the seed banks compared with the regional evergreen forest-dominated flora. These proportions are expected to decline as succession to forest gradually occurs

Cofactor regeneration by a soluble pyridine nucleotide transhydrogenase for biological production of hydromorphone

We have applied the soluble pyridine nucleotide transhydrogenase of Pseudomonas fluorescens to a cell-free system for the regeneration of the nicotinamide cofactors NAD and NADP in the biological production of the important semisynthetic opiate drug hydromorphone. The original recombinant whole-cell system suffered from cofactor depletion resulting from the action of an NADP(+)-dependent morphine dehydrogenase and an NADH-dependent morphinone reductase. By applying a soluble pyridine nucleotide transhydrogenase, which can transfer reducing equivalents between NAD and NADP, we demonstrate with a cell-free system that efficient cofactor cycling in the presence of catalytic amounts of cofactors occurs, resulting in high yields of hydromorphone. The ratio of morphine dehydrogenase, morphinone reductase, and soluble pyridine nucleotide transhydrogenase is critical for diminishing the production of the unwanted by-product dihydromorphine and for optimum hydromorphone yields. Application of the soluble pyridine nucleotide transhydrogenase to the whole-cell system resulted in an improved biocatalyst with an extended lifetime. These results demonstrate the usefulness of the soluble pyridine nucleotide transhydrogenase and its wider application as a tool in metabolic engineering and biocatalysis

Signalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama rot) in dogs in the UK

Seasonal outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) have been reported annually in UK dogs since 2012, yet the aetiology of the disease remains unknown. The objectives of this study were to explore whether any breeds had an increased or decreased risk of being diagnosed with CRGV, and to report on age and sex distributions of CRGV cases occurring in the UK. Multivariable logistic regression was used to compare 101 dogs diagnosed with CRGV between November 2012 and May 2017 with a denominator population of 446,453 dogs from the VetCompass database. Two Kennel Club breed groups—hounds (odds ratio (OR) 10.68) and gun dogs (OR 9.69)—had the highest risk of being diagnosed with CRGV compared with terriers, while toy dogs were absent from among CRGV cases. Females were more likely to be diagnosed with CRGV (OR 1.51) as were neutered dogs (OR 3.36). As well as helping veterinarians develop an index of suspicion for the disease, better understanding of the signalment risk factors may assist in the development of causal models for CRGV and help identify the aetiology of the disease

Vesignieite: a S=12S = \frac{1}{2} kagome antiferromagnet with dominant third-neighbor exchange

The spin-$\frac{1}{2}$ kagome antiferromagnet is an archetypal frustrated system predicted to host a variety of exotic magnetic states. We show using neutron scattering measurements that deuterated vesignieite BaCu$_{3}$V$_{2}$O$_{8}$(OD)$_{2}$, a fully stoichiometric $S=1/2$ kagome magnet with $<$1% lattice distortion, orders magnetically at $T_{\mathrm{N}}=9$K into a multi-k coplanar variant of the predicted triple-k octahedral structure. We find this structure is stabilized by a dominant antiferromagnetic 3$^{\mathrm{rd}}$-neighbor exchange $J_3$ with minor 1$^{\mathrm{st}}$- or 2$^{\mathrm{nd}}$--neighbour exchange. The spin-wave spectrum is well described by a $J_3$-only model including a tiny symmetric exchange anisotropy

Macroscopic Symmetry Group Describes Josephson Tunneling in Twinned Crystals

A macroscopic symmetry group describing the superconducting state of an orthorhombically twinned crystal of YBCO is introduced. This macroscopic symmetry group is different for different symmetries of twin boundaries. Josephson tunneling experiments performed on twinned crystals of YBCO determine this macroscopic symmetry group and hence determine the twin boundary symmetry (but do not experimentally determine whether the microscopic order parameter is primarily d- or s-wave). A consequence of the odd-symmetry twin boundaries in YBCO is the stability of vortices containing one half an elementary flux quantum at the intersection of a twin boundary and certain grain boundaries.Comment: 6 pages, to be published in the Proceedings of the MOS96 Conference in the Journal of Low Temperature Physic

The Population Biology and Transmission Dynamics of Loa loa

Endemic to Central Africa, loiasis – or African eye worm (caused by the filarial nematode Loa loa) – affects more than 10 million people. Despite causing ocular and systemic symptoms, it has typically been considered a benign condition, only of public health relevance because it impedes mass drug administration-based interventions against onchocerciasis and lymphatic filariasis in co-endemic areas. Recent research has challenged this conception, demonstrating excess mortality associated with high levels of infection, implying that loiasis warrants attention as an intrinsic public health problem. This review summarises available information on the key parasitological, entomological, and epidemiological characteristics of the infection and argues for the mobilisation of resources to control the disease, and the development of a mathematical transmission model to guide deployment of interventions

Measurement of the Difference in R=σ_L/σ_T and of σ^A/σ^D in Deep-Inelastic e-D, e-Fe, and e-Au Scattering

We measured the differences in R=σ_L/σ_T and the cross-section ratio σA/σD in deep-inelastic electron scattering from D, Fe, and Au nuclei in the kinematic range 0.2≤x≤0.5 and 1≤Q^2≤5 (Gev/c)^2. Our results for R^A-R^D are consistent with zero for all x and Q^2, indicating that possible contributions to R from nuclear higher-twist effects and spin-0 constituents in nuclei are not different from those in nucleons. The European Muon Collaboration effect is reconfirmed, and the low-x data from all recent experiments, at all Q^2, are now in agreement