Optimising multi-disciplinary contributions for the smart clothing development process

This research aims to introduce a strategic approach to overcome the creative boundaries and optimize multidisciplinary contributions in Smart Clothing development, since the former research results revealed that these issues are key to achieving fully integrated Smart Clothes. Therefore, this paper examines collaborative projects that are shown to break through the creative boundary and integrate multidisciplinary contributions, and identifies how individual designers overcome their creative constraints and collaborate with others, in order to identify a practical method. The research result indicates that a clear description of Smart Clothing’s context will provide a new framework for the developers to work on

An investigation into standards in sustainable design and manufacture

This paper reports upon the application of standards to reduce the negative environmental impacts of manufacturing through product lifecycle planning and closed loop production. By eliminating waste and retaining the energy embodied within materials and components, manufacturing can become more sustainable from both ecological and financial perspectives. Energy consumption and the associated carbon pollution can thus be minimised. Environmental Management System implementation is also considered

Non-homogenous disks in the chain of matrices

We investigate the generating functions of multi-colored discrete disks with non-homogenous boundary conditions in the context of the Hermitian multi-matrix model where the matrices are coupled in an open chain. We show that the study of the spectral curve of the matrix model allows one to solve a set of loop equations to get a recursive formula computing mixed trace correlation functions to leading order in the large matrix limit.Comment: 25 pages, 4 figure

A max-type recursive model: some properties and open questions

We consider a simple max-type recursive model which was introduced in the study of depinning transition in presence of strong disorder, by Derrida and Retaux. Our interest is focused on the critical regime, for which we study the extinction probability, the first moment and the moment generating function. Several stronger assertions are stated as conjectures.Comment: A version accepted to Charles Newman Festschrift (to appear by Springer

Impulsive consensus for complex dynamical networks with nonidentical nodes and coupling time-delays

This paper investigates the problem of global consensus between a complex dynamical network (CDN) and a known goal signal by designing an impulsive consensus control scheme. The dynamical network is complex with respect to the uncertainties, nonidentical nodes, and coupling time-delays. The goal signal can be a measurable vector function or a solution of a dynamical system. By utilizing the Lyapunov function and Lyapunov-Krasovskii functional methods, robust global exponential stability criteria are derived for the error system, under which global exponential impulsive consensus is achieved for the CDN. These criteria are expressed in terms of linear matrix inequalities (LMIs) and algebraic inequalities. Thus, the impulsive controller can be easily designed by solving the derived inequalities. Meanwhile, the estimations of the consensus rate for global exponential consensus are also obtained. Two examples with numerical simulations are worked out for illustration. © 2011 Society for Industrial and Applied Mathematics.published_or_final_versio

Yeast gene CMR1/YDL156W is consistently co-expressed with genes participating in DNA-metabolic processes in a variety of stringent clustering experiments

© 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.The binarization of consensus partition matrices (Bi-CoPaM) method has, among its unique features, the ability to perform ensemble clustering over the same set of genes from multiple microarray datasets by using various clustering methods in order to generate tunable tight clusters. Therefore, we have used the Bi-CoPaM method to the most synchronized 500 cell-cycle-regulated yeast genes from different microarray datasets to produce four tight, specific and exclusive clusters of co-expressed genes. We found 19 genes formed the tightest of the four clusters and this included the gene CMR1/YDL156W, which was an uncharacterized gene at the time of our investigations. Two very recent proteomic and biochemical studies have independently revealed many facets of CMR1 protein, although the precise functions of the protein remain to be elucidated. Our computational results complement these biological results and add more evidence to their recent findings of CMR1 as potentially participating in many of the DNA-metabolism processes such as replication, repair and transcription. Interestingly, our results demonstrate the close co-expressions of CMR1 and the replication protein A (RPA), the cohesion complex and the DNA polymerases α, δ and ɛ, as well as suggest functional relationships between CMR1 and the respective proteins. In addition, the analysis provides further substantial evidence that the expression of the CMR1 gene could be regulated by the MBF complex. In summary, the application of a novel analytic technique in large biological datasets has provided supporting evidence for a gene of previously unknown function, further hypotheses to test, and a more general demonstration of the value of sophisticated methods to explore new large datasets now so readily generated in biological experiments.National Institute for Health Researc

Adjunctive quetiapine for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: A meta-analysis of randomised controlled treatment trials

Small studies have shown positive effects from adding a variety of antipsychotic agents in patients with obsessive–compulsive disorder who are unresponsive to treatment with serotonin reuptake inhibitors. The evidence, however, is contradictory. This paper reports a meta-analysis of existing double-blind randomized placebo-controlled studies looking at the addition of the second-generation antipsychotic quetiapine in such cases. Three studies fulfilled the inclusion criteria. Altogether 102 individuals were subjected to analysis using Review Manager (4.2.7). The results showed evidence of efficacy for adjunctive quetiapine (< 400 mg/day) on the primary efficacy criterion, measured as changes from baseline in total Yale–Brown Obsessive Compulsive Scale scores (P = 0.008), the clinical significance of which was limited by between-study heterogeneity. The mechanism underlying the effect may involve serotonin and/or dopamine neurotransmission