39 research outputs found
Egg production potential and egg quality traits of Black Rock, Red Cornish and Vanaraja chicken reared in coastal climatic condition of Odisha, India
No full textGreen Synthesis, Characterization and Antimicrobial Evaluation of Nano Silver on Mastitis Causing Microorganisms
No full textSubstitution of Ni with NiB prevents shape distortion of liquid phase sintered 90W–6Ni–2Fe–2Co heavy alloys
Full text linkEPIDEMIOLOGICAL STUDY OF ENTEROPATHOGENIC CARRIER STATE AMONG FOOD HANDLERS OF ARMED FORCES EATING ESTABLISHMENTS
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Development, in-vitro characterization and ex-vivo permeation study of metronidazole loaded mucoadhesive ethosomal gel for the local treatment of oral cavity infection
No full textThe present study deals with the formulation, characterization of Metronidazole loaded ethosomal gel for treating oral infection. The ethosomal system of Metronidazole comprises of 2-5% phospholipids, 20-50% ethanol, 10% of propylene glycol, 10% of cholesterol and 10% v/v aqueous phase. Cold method was applied to develop ethosome. The prepared Metronidazole loaded ethosome was evaluated for vesicle size, entrapment efficiency,The Optimized Ethosome formulation was converted in to ethosomal gel. The gel further evaluated for pH, Drug content, mucoadhesive strength and ex-vivo permeation study. The vesicle size of ethosome formulation MEF8 showed the lowest value of 324±1.32 µm. Formulation MEF8 showed the maximum entrapment efficiency of 86.11±0.11%. The mucoadhesive gel MEG8 formulated from optimized ethosome showed the maximum drug release 99.35% in 12 hr and ex-vivo oral mucosa permeation for MEG8 was found to be 1200µg/ml at 30minutes as compared to the pure drug
Development, In-vitro Characterization and Ex-vivo Permeation Study of Metronidazole Loaded Mucoadhesive Ethosomal Gel for the Local Treatment of Oral Cavity Infection
Full text linkThe present study deals with the formulation, characterization of Metronidazole loaded ethosomal gel for treating oral infection. The ethosomal system of Metronidazole comprises of 2-5% phospholipids, 20-50% ethanol, 10% of propylene glycol, 10% of cholesterol and 10% v/v aqueous phase. Cold method was applied to develop ethosome. The prepared Metronidazole loaded ethosome was evaluated for vesicle size, entrapment efficiency,The Optimized Ethosome formulation was converted in to ethosomal gel. The gel further evaluated for pH, Drug content, mucoadhesive strength and ex-vivo permeation study. The vesicle size of ethosome formulation MEF8 showed the lowest value of 324±1.32 µm. Formulation MEF8 showed the maximum entrapment efficiency of 86.11±0.11%. The mucoadhesive gel MEG8 formulated from optimized ethosome showed the maximum drug release 99.35% in 12 hr and ex-vivo oral mucosa permeation for MEG8 was found to be 1200µg/ml at 30minutes as compared to the pure drug
