24 research outputs found
Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients
Get PDFSynthesis of Eight‐Membered Lactams through Formal [6+2] Cyclization of Siloxy Alkynes and Vinylazetidines
No full textAza-[2,3]-Wittig Sigmatropic Rearrangement of Allylic Tertiary Amines: A Successful Example with High Chirality Transfer
Full text linkSynthesis of homopropargylamines from 2-cyanoazetidines
No full textInternational audienceMild generation of vinylidene carbene from α-amino nitrile is the basis of a new synthesis of homopropargylamines
Novel liposaccharide conjugates for drug and peptide delivery
No full textSugar-lipid conjugates with general structure 1-4 were prepared by coupling amino sugars with N-Boc-protected lipoamino acids and oligomers. Conjugates with general structure 5 were also prepared from glucuronic acid and methyl 2-aminohexadecanoate. The physicochemical properties of the conjugates were modified by varying the nature and number of sugars or the number of lipoamino acids or their alkyl chain length. The ability of the liposaccharides to aggregate was examined. These preliminary experiments have demonstrated the ability of the liposaccharides to form particulate systems per se and also their ability to be incorporated into conventional liposomal systems. The structure of the respective liposaccharides and the molar ratio of liposaccharide to dimyristoyl lecithin and cholesterol were found to have a profound effect on the type of colloidal systems produced
Aza-[2,3]-Wittig Sigmatropic Rearrangement of Allylic Tertiary Amines: A Successful Example with High Chirality Transfer
No full textWe report herein a successful example
of an aza-[2,3]-Wittig rearrangement
in an allylic tertiary <i>N,N</i>-dibenzyl amine derived
from (<i>S</i>)-alaninol or (<i>S</i>)-isoleucinol.
This reaction occurs upon metalation at the benzylic position with
a mixture of butyllithium/diisopropylamine/potassium <i>t</i>-butoxide and proceeds with a high 1,3 transfer of chirality
Aza-[2,3]-Wittig Sigmatropic Rearrangement of Allylic Tertiary Amines: A Successful Example with High Chirality Transfer
No full textWe report herein a successful example
of an aza-[2,3]-Wittig rearrangement
in an allylic tertiary <i>N,N</i>-dibenzyl amine derived
from (<i>S</i>)-alaninol or (<i>S</i>)-isoleucinol.
This reaction occurs upon metalation at the benzylic position with
a mixture of butyllithium/diisopropylamine/potassium <i>t</i>-butoxide and proceeds with a high 1,3 transfer of chirality
Handbook on participatory land use planning : methods and tools developed and tested in Viengkham district, Luang Prabang Province
No full text
