Record linkage under suboptimal conditions for data-intensive evaluation of primary care in Rio de Janeiro, Brazil

Background Linking Brazilian databases demands the development of algorithms and processes to deal with various challenges including the large size of the databases, the low number and poor quality of personal identifiers available to be compared (national security number not mandatory), and some characteristics of Brazilian names that make the linkage process prone to errors. This study aims to describe and evaluate the quality of the processes used to create an individual-linked database for data-intensive research on the impacts on health indicators of the expansion of primary care in Rio de Janeiro City, Brazil. Methods We created an individual-level dataset linking social benefits recipients, primary health care, hospital admission and mortality data. The databases were pre-processed, and we adopted a multiple approach strategy combining deterministic and probabilistic record linkage techniques, and an extensive clerical review of the potential matches. Relying on manual review as the gold standard, we estimated the false match (false-positive) proportion of each approach (deterministic, probabilistic, clerical review) and the missed match proportion (false-negative) of the clerical review approach. To assess the sensitivity (recall) to identifying social benefits recipients’ deaths, we used their vital status registered on the primary care database as the gold standard. Results In all linkage processes, the deterministic approach identified most of the matches. However, the proportion of matches identified in each approach varied. The false match proportion was around 1% or less in almost all approaches. The missed match proportion in the clerical review approach of all linkage processes were under 3%. We estimated a recall of 93.6% (95% CI 92.8–94.3) for the linkage between social benefits recipients and mortality data. Conclusion The adoption of a linkage strategy combining pre-processing routines, deterministic, and probabilistic strategies, as well as an extensive clerical review approach minimized linkage errors in the context of suboptimal data quality

Impact and Cost-Effectiveness of Culture for Diagnosis of Tuberculosis in HIV-Infected Brazilian Adults

Culture of Mycobacterium tuberculosis currently represents the closest "gold standard" for diagnosis of tuberculosis (TB), but operational data are scant on the impact and cost-effectiveness of TB culture for human immunodeficiency (HIV-) infected individuals in resource-limited settings.We recorded costs, laboratory results, and dates of initiating TB therapy in a centralized TB culture program for HIV-infected patients in Rio de Janeiro, Brazil, constructing a decision-analysis model to estimate the incremental cost-effectiveness of TB culture from the perspective of a public-sector TB control program. Of 217 TB suspects presenting between January 2006 and March 2008, 33 (15%) had culture-confirmed active tuberculosis; 23 (70%) were smear-negative. Among smear-negative, culture-positive patients, 6 (26%) began TB therapy before culture results were available, 11 (48%) began TB therapy after culture result availability, and 6 (26%) did not begin TB therapy within 180 days of presentation. The cost per negative culture was US$17.52 (solid media)-$23.50 (liquid media). Per 1,000 TB suspects and compared with smear alone, TB culture with solid media would avert an estimated eight TB deaths (95% simulation interval [SI]: 4, 15) and 37 disability-adjusted life years (DALYs) (95% SI: 13, 76), at a cost of $36 (95$25, $50) per TB suspect or$962 (95% SI: $469,$2642) per DALY averted. Replacing solid media with automated liquid culture would avert one further death (95% SI: -1, 4) and eight DALYs (95% SI: -4, 23) at $2751 per DALY (95$680, dominated). The cost-effectiveness of TB culture was more sensitive to characteristics of the existing TB diagnostic system than to the accuracy or cost of TB culture.TB culture is potentially effective and cost-effective for HIV-positive patients in resource-constrained settings. Reliable transmission of culture results to patients and integration with existing systems are essential

Preventive therapy for HIV-associated tuberculosis

Purpose of review: Tuberculosis (TB) remains the leading cause of death in people living with HIV (PLHIV) despite the achievements in antiretroviral therapy coverage. TB preventive therapy (TPT) has proved efficacy but has been neglected and poorly implemented. We reviewed recent publications and guidelines about TPT in PLHIV. Recent findings: High-quality studies showed that TPT has a durable effect, over 5 years, preventing TB and all-cause mortality. There is new evidence showing the noninferiority of shorter, rifamycin-based regimens of TPT increasing the options for treatment. Recent studies describing robust implementation in different settings showed promising results for feasibility, tolerance, retention, and cost-effectiveness. New WHO recommendations, unifying previous versions, have been released to guide countries implementation. Summary: New evidence support the scale up of TPT for PLHIV globally, further studies are needed to bring more evidence for specific populations, like pregnant women and for drug–drug interactions with antiretroviral agents.2020-07-0

Primary health care expansion and mortality in Brazil’s urban poor: a cohort analysis of 1.2 million adults

Background Expanding delivery of primary health care to urban poor populations is a priority in many low-and middle-income countries. This remains a key challenge in Brazil despite expansion of the country’s internationally recognised Family Health Strategy (FHS) over the past two decades. This study evaluates the impact of an ambitious program to rapidly expand FHS coverage in the city of Rio de Janeiro, Brazil since 2008. Methods and Findings A cohort of 1,241,351 million low-income adults (observed January 2010-December 2016; total person-years 6,498,607) with linked FHS utilisation and mortality records was analysed using flexible parametric survival models. Time-to-death from all-causes and selected causes were estimated for FHS users and non-users. Models employed inverse probability treatment weighting and regression adjustment (IPTW-RA). The cohort was 61% female (751,895) and had a mean age of 36 years (standard deviation 16.4). Only 18,721 individuals (1.5%) had higher education whilst 102,899 (8%) had no formal education. Two-thirds of individuals (827250; 67%) were in receipt of conditional cash transfers (Bolsa Família). A total of 34,091 deaths were analysed of which 8,765 (26%) were due to cardiovascular disease, 5,777 (17%) due to neoplasms, 5,683 (17%) due to external causes, 3,152 (9%) due to respiratory diseases, and 3,115 (9%) due to infectious and parasitic diseases. One third of the cohort (467,155; 37.6%) used FHS services. In IPTW-RA survival analysis, an average FHS user had a 44% lower hazard of all-cause mortality (HR: 0.56, 95%CI: 0.54 to 0.59, p<0.001) and a five-year risk reduction of 8.3 per 1000 (95%CI: 7.8 to 8.9, p<0.001) compared to a non-FHS user. There were greater reductions in the risk of death for FHS users who: were black (HR:0.50 (95%CI: 0.46 to 0.54, p<0.001)) or pardo (HR:0.57 (95%CI: 0.54 to 0.60, p<0.001) compared to white (HR:0.59 (95%CI: 0.56 to 0.63, p<0.001); had lower educational attainment (HR:0.50 (95%CI: 0.46 to 0.55, p<0.001) for those with no education compared to no significant association for those with higher education (p=0.758)); or were in receipt of conditional cash transfers (Bolsa Família) (HR:0.51 (95%CI: 0.49 to 0.54, p<0.001) compared to HR:0.63 (95%CI: 0.60 to 0.67, p<0.001) for non-recipients). Key limitations in this study are potential unobserved confounding through selection into the programme and linkage errors, although analytical approaches have minimized the potential for bias. Conclusions FHS utilisation in urban poor populations in Brazil was associated with a lower risk of death, with greater reductions among more deprived ethnic and socio-economic groups. Increased investment in primary health care is likely to improve health and reduce health inequalities in urban poor populations globally