The KELT-South Telescope

The Kilodegree Extremely Little Telescope (KELT) project is a survey for new transiting planets around bright stars. KELT-South is a small-aperture, wide-field automated telescope located at Sutherland, South Africa. The telescope surveys a set of 26 degree by 26 degree fields around the southern sky, and targets stars in the range of 8 < V < 10 mag, searching for transits by Hot Jupiters. This paper describes the KELT-South system hardware and software and discusses the quality of the observations. We show that KELT-South is able to achieve the necessary photometric precision to detect transits of Hot Jupiters around solar-type main-sequence stars.Comment: 26 pages, 13 figure

Clear sky fraction above Indonesia: an analysis for astronomical site selection

We report a study of cloud cover over Indonesia based on meteorological satellite data, spanning over the past 15 years (from 1996 to 2010) in order to be able to select a new astronomical site capable to host a multi-wavelength astronomical observatory. High spatial resolution of meteorological satellite data acquired from {\it Geostationary Meteorological Satellite 5} ({\it GMS 5}), {\it Geostationary Operational Environmental Satellite 9} ({\it GOES 9}), and {\it Multi-functional Transport Satellite-1R} ({\it MTSAT-1R}) are used to derive yearly average clear fractions over the regions of Indonesia. This parameter is determined from temperature measurement of the IR3 channel (water vapor, 6.7 $\mu$m) for high altitude clouds (cirrus) and from the IR1 channel (10.7 $\mu$m) for lower altitude clouds. Accordingly, an algorithm is developed to detect the corresponding clouds. The results of this study are then adopted to select the best possible sites in Indonesia to be analysed further by performing in situ measurements planned for the coming years. The results suggest that regions of East Nusa Tenggara, located in south-eastern part of Indonesia, are the most promising candidates for such an astronomical site. Yearly clear sky fraction of this regions may reach better than 70 per cent with an uncertainty of 10 per cent.Comment: 15 pages, 13 figures, and 4 table

Skin Cancers Among Albinos at a University Teaching Hospital in Northwestern Tanzania: A Retrospective Review of 64 Cases.

Skin cancers are a major risk associated with albinism and are thought to be a major cause of death in African albinos. The challenges associated with the care of these patients are numerous and need to be addressed. The aim of this study was to outline the pattern and treatment outcome of skin cancers among albinos treated at our centre and to highlight challenges associated with the care of these patients and proffer solutions for improved outcome. This was a retrospective study of all albinos with a histopathological diagnosis of skin cancer seen at Bugando Medical Centre from March 2001 to February 2010. Data collected were analyzed using descriptive statistics. A total of 64 patients were studied. The male to female ratio was 1.5:1. The median age of patients was 30 years. The median duration of illness at presentation was 24 months. The commonest reason for late presentation was financial problem. Head and the neck was the most frequent site afflicted in 46(71.8%) patients. Squamous cell carcinoma was the most common histopathological type in 75% of cases. Surgical operation was the commonest modality of treatment in 60 (93.8%) patients. Radiotherapy was given in 24(37.5%) patients. Twenty-seven (42.2%) of the patients did not complete their treatment due to lack of funds. Local recurrence following surgical treatment was recorded in 6 (30.0%) patients. Only thirty-seven (61.7%) patients were available for follow-up at 6-12 months and the remaining patients were lost to follow-up. Skin cancers are the most common cancers among albinos in our environment. Albinism and exposure to ultraviolet light appears to be the most important risk factor in the development of these cancers. Late presentation and failure to complete treatment due to financial difficulties and lack of radiotherapy services at our centre are major challenges in the care of these patients. Early institution of preventive measures, early presentation and treatment, and follow-up should be encouraged in this population for better outcome

God, Others, and Ourselves - The Stories We Tell and the Meaning We Make: A Narrative Approach to Adventist Mission in the South England Conference of the British Union Conference, United Kingdom

Problem A disconnect exists between the Adventist Church in the United Kingdom and its wider context as evidenced through the reduced number of accessions coming from the majority population and from second, third, and subsequent migrant generations. This present study was to propose and trial a worldview awareness training experience. Method A Six Conversation journey experience was devised and presented over a six-week period in the summer of 2021 via Zoom, in line with adaptations due to the COVID pandemic. Volunteer Adventist participants would explore their individual and collective meaning and identity narratives, grow awareness and understanding of other such narratives in their context, and engage these meaning/identity narratives considering a Scriptural perspective in which God consistently seeks ways to be among, and identify with, humankind. Seven participants agreed to be interviewed at the conclusion of the training experience. Qualitative interview data was evaluated using the Kirkpatrick model for training evaluation. Results The study brought a range of individuals together with varying ethnic and national identities and invited them to journey together for six weeks. The online nature of the presentations and interactions were a hindrance to relational interface intended to draw participants into the experiences and perspectives of others. Nevertheless, interviewees shared regarding intersecting points with their faith journey that brought both affirmation and challenge, while also indicating that intervention concepts were found to be worthwhile in individual mission and ministry contexts. Most expressed confidence that they would be able to practice these locally. At time of evaluation there are no visible or discernible Level 4 outcomes due, in part, to the nature of the online platform combined with participants who were not otherwise known to one another and who were geographically separated, but more importantly because such outcomes cannot be meaningfully measured two to four weeks after the Six Conversation experience. Conclusions While the qualitative data does not seek to objectively measure the results of the intervention, the insights gained from this study suggest, (a) value in and appetite for the general approach, (b) the desire from a diverse church membership for the journeying experience, and (c) that there should be further, more intentional development of the intervention for a hybrid digital/in-person experience to facilitate the maturing and expansion of the concepts. This intervention appears to have found touch points within the Adventist community in the UK

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine.

Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P. falciparum multidrug resistance 1 (pfmdr1) genes are associated with decreased sensitivity to amodiaquine and lumefantrine, but effects of these polymorphisms on therapeutic responses to artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) have not been clearly defined. Individual patient data from 31 clinical trials were harmonized and pooled by using standardized methods from the WorldWide Antimalarial Resistance Network. Data for more than 7,000 patients were analyzed to assess relationships between parasite polymorphisms in pfcrt and pfmdr1 and clinically relevant outcomes after treatment with AL or ASAQ. Presence of the pfmdr1 gene N86 (adjusted hazards ratio = 4.74, 95% confidence interval = 2.29 - 9.78, P < 0.001) and increased pfmdr1 copy number (adjusted hazards ratio = 6.52, 95% confidence interval = 2.36-17.97, P < 0.001 : were significant independent risk factors for recrudescence in patients treated with AL. AL and ASAQ exerted opposing selective effects on single-nucleotide polymorphisms in pfcrt and pfmdr1. Monitoring selection and responding to emerging signs of drug resistance are critical tools for preserving efficacy of artemisinin combination therapies; determination of the prevalence of at least pfcrt K76T and pfmdr1 N86Y should now be routine

Ring closing reaction in diarylethene captured by femtosecond electron crystallography

The photoinduced ring-closing reaction in diarylethene, which serves as a model system for understanding reactive crossings through conical intersections, was directly observed with atomic resolution using femtosecond electron diffraction. Complementary ab initio calculations were also performed. Immediately following photoexcitation, subpicosecond structural changes associated with the formation of an open-ring excited-state intermediate were resolved. The key motion is the rotation of the thiophene rings, which significantly decreases the distance between the reactive carbon atoms prior to ring closing. Subsequently, on the few picosecond time scale, localized torsional motions of the carbon atoms lead to the formation of the closed-ring photoproduct. These direct observations of the molecular motions driving an organic chemical reaction were only made possible through the development of an ultrabright electron source to capture the atomic motions within the limited number of sampling frames and the low data acquisition rate dictated by the intrinsically poor thermal conductivity and limited photoreversibility of organic materials

Identification and characterization of a novel non-structural protein of bluetongue virus

Bluetongue virus (BTV) is the causative agent of a major disease of livestock (bluetongue). For over two decades, it has been widely accepted that the 10 segments of the dsRNA genome of BTV encode for 7 structural and 3 non-structural proteins. The non-structural proteins (NS1, NS2, NS3/NS3a) play different key roles during the viral replication cycle. In this study we show that BTV expresses a fourth non-structural protein (that we designated NS4) encoded by an open reading frame in segment 9 overlapping the open reading frame encoding VP6. NS4 is 77–79 amino acid residues in length and highly conserved among several BTV serotypes/strains. NS4 was expressed early post-infection and localized in the nucleoli of BTV infected cells. By reverse genetics, we showed that NS4 is dispensable for BTV replication in vitro, both in mammalian and insect cells, and does not affect viral virulence in murine models of bluetongue infection. Interestingly, NS4 conferred a replication advantage to BTV-8, but not to BTV-1, in cells in an interferon (IFN)-induced antiviral state. However, the BTV-1 NS4 conferred a replication advantage both to a BTV-8 reassortant containing the entire segment 9 of BTV-1 and to a BTV-8 mutant with the NS4 identical to the homologous BTV-1 protein. Collectively, this study suggests that NS4 plays an important role in virus-host interaction and is one of the mechanisms played, at least by BTV-8, to counteract the antiviral response of the host. In addition, the distinct nucleolar localization of NS4, being expressed by a virus that replicates exclusively in the cytoplasm, offers new avenues to investigate the multiple roles played by the nucleolus in the biology of the cell

Factors Affecting Teaching and Learning of Square Roots without Calculators in Secondary Schools: A Case Study of 6 Secondary Schools in Mpika District, Zambia

This study was undertaken to determine the factors affecting the teaching and learning of square roots of real numbers without the calculators in secondary schools in Mpika District. Three research questions were raised and answered by administering questionnaires. Data was collected by means of four different questionnaires administered to twenty one teachers of mathematics, six Heads of Mathematics Department and one hundred and seventy four pupils drawn from six secondary schools in Mpika District. The five points Likert rating scale was used in determining the factors. Data was analyzed using simple frequency counts, percentages and analysis of variance. The results of the study showed that lack of content knowledge among the teachers, lack of educational materials and library facilities were the factors responsible for not teaching the topic without the calculators. For the pupils, it was due to lack of appropriate mathematics text books, not being taught by the teachers and failure to be given at the beginning of the term the  course outline of the mathematics topics to be taught in the term. Some strategies have been adopted to enhance the teaching and learning of square roots without the calculators and a number of recommendations have been made to the government and other stakeholders involved in the provision of education. Keywords: Teaching, learning, square roots, secondary schools, algorithm, calculato