Haemodialysis activates phospholipase A2 enzyme

Background Clinical and experimental evidence suggest that haemodialysis (HD) procedure is an inflammatory process. For the production of proinflammatory lipid mediators in many inflammatory reactions, the release of arachidonic acid by phospholipase A2 (PLA2 enzyme is a prerequisite. Therefore, the purpose of the present investigation was to establish whether the activity of PLA2 increases during HD and whether the increase depends on the type of dialyser used. Methods We performed dialysis in eight chronic HD patients. Blood samples entering and leaving the dialyser were obtained before and at 15, 60, 120 and 180 min after the dialysis was started, on one occasion using a cuprophane and on another occasion a cellulose triacetate dialyser. PLA2 activity was assessed in crude plasma and in plasma extract. Results PLA2 activity in plasma extract exhibited similar biochemical properties to that of inflammatory human synovial fluid PLA2 enzyme which is of group II PLA2. PLA2 activity in crude plasma represents a type of PLA2 other than the synovial type. In HD patients, baseline PLA2 activities in crude plasma and plasma extract were significantly increased when compared to normal subjects. An increase in PLA2 activity was observed in crude plasma with a peak appearing at 15 min when the patients were dialysed with cuprophane and cellulose triacetate membranes. This increase was observed in both arterial and venous blood samples and was more pronounced when the patients were dialysed with cuprophane than with cellulose triacetate membranes. When PLA2 was assessed in plasma extract, the activity increased only with cuprophane but not with cellulose triacetate membranes. Conclusions PLA2 activity in plasma is increased in HD patients and increases during the dialysis procedure to a greater extent with a less biocompatible membrane. Continuous activation of PLA2 might be relevant for long-term deleterious consequences of H

Effect of Central Mass Concentration on the Formation of Nuclear Spirals in Barred Galaxies

We have performed smoothed particle hydrodynamics (SPH) simulations to study the response of the central kiloparsec region of a gaseous disk to the imposition of nonaxisymmetric bar potentials. The model galaxies are composed of the three axisymmetric components (halo, disk, and bulge) and a non-axisymmetric bar. These components are assumed to be invariant in time in the frame corotating with the bar. The potential of spherical $\gamma$-models of Dehnen is adopted for the bulge component whose density varies as $r^{-\gamma}$ near the center and $r^{-4}$ at larger radiiand hence, possesses a central density core for $\gamma = 0$ and cusps for $\gamma > 0$. Since the central mass concentration of the model galaxies increases with the cusp parameter $\gamma$, we have examined here the effect of the central mass concentration by varying the cusp parameter $\gamma$ on the mechanism responsible for the formation of the symmetric two-armed nuclear spirals in barred galaxies. Our simulations show that the symmetric two-armed nuclear spirals are formed by hydrodynamic spiral shocks driven by the gravitational torque of the bar for the models with $\gamma = 0$ and 0.5. On the other hand, the symmetric two-armed nuclear spirals in the models with $\gamma=1$ and 1.5 are explained by gas density waves. Thus, we conclude that the mechanism responsible for the formation of the symmetric two-armed nuclear spirals in barred galaxies changes from the hydrodynamic shocks to the gas density waves when the central mass concentration increases from $\gamma = 0$ to 1.5.Comment: 29 pages, 5 figures (Color Figures 3-5), Accepted for Publication in Astrophysical Journal (ApJ

The Pattern Speed of the Galactic Bar

Most late-type stars in the solar neighborhood have velocities similar to the local standard of rest (LSR), but there is a clearly separated secondary component corresponding to a slower rotation and a mean outward motion. Detailed simulations of the response of a stellar disk to a central bar show that such a bi-modality is expected from outer-Lindblad resonant scattering. When constraining the run of the rotation curve by the proper motion of Sgr A* and the terminal gas velocities, the value observed for the rotation velocity separating the two components results in a value of (53+/-3)km/s/kpc for the pattern speed of the bar, only weakly dependent on the precise values for Ro and bar angle phi.Comment: 5 pages LaTeX, 2 Figs, accepted for publication in ApJ Letter

On the age heterogeneity of the Pleiades, Hyades and Sirius moving groups

We investigate the nature of the classical low-velocity structures in the local velocity field, i.e. the Pleiades, Hyades and Sirius moving groups. After using a wavelet transform to locate them in velocity space, we study their relation with the open clusters kinematically associated with them. By directly comparing the location of moving group stars in parallax space to the isochrones of the embedded clusters, we check whether, within the observational errors on the parallax, all moving group stars could originate from the on-going evaporation of the associated cluster. We conclude that, in each moving group, the fraction of stars making up the velocity-space overdensity superimposed on the background is higher than the fraction of stars compatible with the isochrone of the associated cluster. These observations thus favour a dynamical (resonant) origin for the Pleiades, Hyades and Sirius moving groups.Comment: 8 pages, 8 figures, accepted for publication in A&

The properties of the Galactic bar implied by gas kinematics in the inner Milky Way

Longitude-velocity (l-V) diagrams of H I and CO gas in the inner Milky Way have long been known to be inconsistent with circular motion in an axisymmetric potential. Several lines of evidence suggest that the Galaxy is barred, and gas flow in a barred potential could be consistent with the observed ``forbidden'' velocities and other features in the data. We compare the H I observations to l-V diagrams synthesized from 2-D fluid dynamical simulations of gas flows in a family of barred potentials. The gas flow pattern is very sensitive to the parameters of the assumed potential, which allows us to discriminate among models. We present a model that reproduces the outer contour of the H I l-V diagram reasonably well; this model has a strong bar with a semimajor axis of 3.6 kpc, an axis ratio of approximately 3:1, an inner Lindblad resonance (ILR), and a pattern speed of 42 km/s/kpc, and matches the data best when viewed from 34\deg to the bar major axis. The behavior of the models, combined with the constraint that the shocks in the Milky Way bar should resemble those in external barred galaxies, leads us to conclude that wide ranges of parameter space are incompatible with the observations. In particular we suggest that the bar must be fairly strong, must have an ILR, and cannot be too end-on, with the bar major axis at 35\deg +/- 5\deg to the line of sight. The H I data exhibit larger forbidden velocities over a wider longitude range than are seen in molecular gas; this important difference is the reason our favored model differs so significantly from other recently proposed models.Comment: 23 pages, 14 figures, 1 table, uses emulateapj and psfig, 640 kb. Submitted to Ap

Kinematics of the Galactic Globular Cluster System: New Radial Velocities for Clusters in the Direction of the Inner Galaxy

HIRES on the Keck I telescope has been used to measure the first radial velocities for stars belonging to eleven, heavily-reddened globular clusters in the direction of the inner Galaxy. The question of kinematic substructuring among the Galactic globular cluster system is investigated using an updated catalog of globular cluster distances, metallicities and velocities. It is found that the population of metal-rich globular clusters shows significant rotation at all Galactocentric radii. For the metal-rich clusters within 4 kpc of the Galactic center, the measured rotation velocity and line-of-sight velocity dispersion are similar to those of bulge field stars. We investigate claims that the metal-rich clusters are associated with the central Galactic bar by comparing the kinematics of the innermost clusters to that of the atomic hydrogen in the inner Galaxy. The longitude-velocity diagram of both metal-rich and metal-poor clusters bears a remarkable similarity to that of the gas, including the same non-circular motions which have traditionally been interpreted as evidence for a Galactic bar, or, alternatively, a non-axisymmetric bulge. However, uncertainties in the existing three-dimensional Galactocentric positions for most of the clusters do not yet allow an unambiguous discrimination between the competing scenarios of membership in a rigidly rotating bar, or in a bulge which is an oblate isotropic rotator. We conclude that the majority of metal-rich clusters within the central 4 kpc of the Galaxy are probably associated with the bulge/bar, and not the thick disk. (ABRIDGED)Comment: 18 pages, including 7 of 13 postscript figures. Figures 1-6 available at http://astro.caltech.edu/~pc. Accepted for publication in the Astronomical Journa

Constraints on the Galactic bar from the Hercules stream as traced with RAVE across the Galaxy

Non-axisymmetries in the Galactic potential (spiral arms and bar) induce kinematic groups such as the Hercules stream. Assuming that Hercules is caused by the effects of the outer Lindblad resonance of the Galactic bar, we model analytically its properties as a function of position in the Galaxy and its dependence on the bar's pattern speed and orientation. Using data from the RAVE survey we find that the azimuthal velocity of the Hercules structure decreases as a function of Galactocentric radius, in a manner consistent with our analytical model. This allows us to obtain new estimates of the parameters of the Milky Way's bar. The combined likelihood function of the bar's pattern speed and angle has its maximum for a pattern speed of Omega(b) = (1.89 +/- 0.08) x Omega(0), where Omega(0) is the local circular frequency. Assuming a solar radius of 8.05 kpc and a local circular velocity of 238 km s(-1), this corresponds to Omega(b) = 56 +/- 2km s(-1) kpc(-1). On the other hand, the bar's orientation phi(b) cannot be constrained with the available data. In fact, the likelihood function shows that a tight correlation exists between the pattern speed and the orientation, implying that a better description of our best fit results is given by the linear relation Omega(b)/Omega(0) = 1.91+0.0044 (phi(b)(deg) - 48), with standard deviation of 0.02. For example, for an angle of phi(b) = 30 deg the pattern speed is 54.0 +/- 0.5 km s(-1) kpc(-1). These results are not very sensitive to the other Galactic parameters such as the circular velocity curve or the peculiar motion of the Sun, and are robust to biases in distance

Equilibrium Disk-Bulge-Halo Models for the Milky Way and Andromeda Galaxies

We describe a new set of self-consistent, equilibrium disk galaxy models that incorporate an exponential disk, a Hernquist model bulge, an NFW halo and a central supermassive black hole. The models are derived from explicit distribution functions for each component and the large number of parameters permit detailed modeling of actual galaxies. We present techniques that use structural and kinematic data such as radial surface brightness profiles, rotation curves and bulge velocity dispersion profiles to find the best-fit models for the Milky Way and M31. Through N-body realizations of these models we explore their stability against the formation of bars. The models permit the study of a wide range of dynamical phenomenon with a high degree of realism.Comment: 58 pages, 20 figures, submitted to the Astrophysical Journa

Relationship between the Velocity Ellipsoids of Galactic-Disk Stars and their Ages and Metallicities

The dependences of the velocity ellipsoids of F-G stars of the thin disk of the Galaxy on their ages and metallicities are analyzed based on the new version of the Geneva-Copenhagen Catalog. The age dependences of the major, middle, and minor axes of the ellipsoids, and also of the dispersion of the total residual veltocity, obey power laws with indices 0.25,0.29,0.32, and 0.27 (with uncertainties \pm 0.02). Due to the presence of thick-disk objects, the analogous indices for all nearby stars are about a factor of 1.5 larger. Attempts to explain such values are usually based on modeling relaxation processes in the Galactic disk. With increasing age, the velocity ellipsoid increases in size and becomes appreciably more spherical, turns toward the direction of the Galactic center, and loses angular momentum. The shape of the velocity ellipsoid remains far from equilibrium. With increasing metallicity, the velocity ellipsoid for stars of mixed age increases in size, displays a weak tendency to become more spherical, and turns toward the direction of the Galactic center (with these changes occurring substantially more rapidly in the transition through the metallicity [Fe/H]= -0.25). Thus, the ellipsoid changes similarly to the way it does with age; however, with decreasing metallicity, the rotational velocity about the Galactic center monotonically increases, rather than decreases(!). Moreover, the power-law indices for the age dependences of the axes depend on the metallicity, and display a maximum near [Fe/H]=-0.1. The age dependences of all the velocity-ellipsoid parameters for stars with equal metallicity are roughly the same. It is proposed that the appearance of a metallicity dependence of the velocity ellipsoids for thin-disk stars is most likely due to the radial migration of stars.Comment: 15 pages, 6 figures, accepted 2009, Astronomy Reports, Vol. 53 No. 9, P.785-80

The needle in the haystack - Where to look for more isolated cooling neutron stars

Context: Isolated cooling neutron stars with thermal X-ray emission remain rarely detected objects despite many searches investigating the ROSAT data. Aims: We simulate the population of close-by young cooling neutron stars to explain the current observational results. Given the inhomogeneity of the neutron star distribution on the sky it is particularly interesting to identify promising sky regions with respect to on-going and future searches. Methods: Applying a population synthesis model the inhomogeneity of the progenitor distribution and the inhomogeneity of the X-ray absorbing interstellar medium are considered for the first time. The total number of observable neutron stars is derived with respect to ROSAT count rates. In addition, we present sky maps of neutron star locations and discuss age and distance distributions of the simulated neutron stars. Implications for future searches are discussed. Results: With our advanced model we can successfully explain the observed logN - logS distribution of close-by neutron stars. Cooling neutron stars will be most abundant in the directions of rich OB associations. New candidates are expected to be identified behind the Gould Belt, in particular in the Cygnus-Cepheus region. They are expected to be on average younger and then hotter than the known population of isolated cooling neutron stars. In addition, we propose to use data on runaway stars to search for more radio-quiet cooling neutron stars.Comment: 18 pages, 14 figures; added Erratum after bug in code was discovered, updated results in Appendix, main conclusions do not chang