A collaborative environment for distributed Web-based CAD

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, June 1999.Includes bibliographical references (p. 67-69).by Gangadhar Konduri.S.M

Design and Evaluation of Fluoxetine Orodispersible Tablets.

This study is to design and development of fluoxetine oral disintegrant tablet by using different superdisintegrants like crospovidone, croscarmellose sodium and sodium starch glycolate. And also present work aims that effect on diluents on disintegration power and in vitro dissolution of the tablets. Fluoxetine HCL orodispersible tablet was developed by using various superdisintegrant. Formulation contains crospovidone and mannitol showed quick disintegration behavior. In vitro release profile indicates that formulation F9 showed better release of drug. It is concluded from the above study that 5%w/w crospovidone as Superdisintegrant and mannitol as filler most suitable for preparation of fluoxetine Hydrochloride oral disintegrating tablet. Short term stability study of Fluoxetine Hydrochloride orally disintegrating tablet was carried out for 2 month at 40�C/75%RH. Results of stability study revealed that no change was observed in formulation throughout the stability study. It can be concluded that fluoxetine hcl orodispersible tablet may have good shelf life

Toxic Effects of Glyphosate on Environment and Human Health

Globally, massive amounts of pesticides are manufactured and used both in agriculture and households to get rid of various pests, some of which reach soils and aquatic systems through various pathways. Glyphosate-based herbicides (GlyBH), including Roundup, are the most widely used pesticides worldwide. Glyphosate is a non-selective herbicide that is effective against all types of weeds and has been used for many years. Their uses have increased exponentially since their introduction into the market. Residue levels in food or water, as well as human exposures, are escalating including in the environmental segments. It can, therefore, be found as a contaminant in water, and procedures are required for its removal. This work investigates the toxic effects associated with the use of Glyphosate on environmental and human health. © 2020 Author(s).Dr. BGR is highly thankful to UGC for the award of Post Doctoral Fellowship, File No. F./PDFSS-2014-15-SCAND-7541

Depletion of glutathione and enhanced lipid peroxidation in the CSF of acute psychotics following haloperidol administration

Haloperidol administration for 2 weeks results in significant reduction in the concentration of GSH in the CSF. Concomitantly, the levels of lipid peroxidation products increased as evidenced by increased malondialdehyde levels. The malondialdehyde levels in the CSF prior to haloparidol administration were not significantly higher than that seen in CSF from normal controls (data not shown) suggesting that increased oxidative stress did not exist in these patients prior to haloperidol administration. All the patients included in the present study were drug naive and hence the changes observed in the glutathione and malon6ialdehyde levels in the CSF were indeed mediated by haloperidol administration. The only other medication that was administered namely, anticholinergic drug, trihexyphenidyl is not known to cause any oxidative stress. The present study thus demonsuates that haloperidol administration results in significant oxidative stress. The generation of the oxidative stress is probably due to the increased turnover of dopemine caused by typical neuroleptics. Increased dopamine turnover is also observed in Parkinson's disease and the combination therapy consisting of antioxidant vitamin E and monoamine oxidase inhibitor, deprenyl has been shown to offer limited protection against the progression of the disease (Parkinson Disease Study Group 1989). In the present study, all the 15 patients exhibited extrapyramidal symptoms although the time of onset, the duration and the severity of the side effects differed between patients. On the presumption that the oxidative stress generated by haloperidel may cause extrapyramidal symptoms, the present study in humans taken together with the evidence provided in our earlier studies on rats (Shivakumar and Ravindranath 1992,1993) may justify experimental coadministration of antioxidanls (e.g., vitamin E) with typical neuroleptics like haloperidol to prevent the acute side effects

ANTI-INFLAMMATORY ACTIVITY OF TRAUMEEL (A HOMEOPATHIC PREPARATION) IN EXPERIMENTAL ANIMALS-RATS

 Objective: To evaluate the anti-inflammatory effect of traumeel on acute and chronic inflammatory experimental animal models (rats).Methods: The traumeel, a homeo medicinal preparation was tested for its efficacy in acute and chronic inflammatory rats. In acute models: Rat pawedema method was used. In this model, rats were divided into four groups, six rats each. Group-I (NC), received 2% GA 2 ml, Group-II (PC) receivedaspirin (200 mg/kg), Group-III, intravenous received low dose (6CH) and high dose (300CH) of traumeel, preparation orally. Edema was developed ininjected paw. Immediately the foot edema volume was measured at 0 hr and at the end of 3rd hr with a plethysmograph. The percentage of inhibitionof edema by drugs was measured and compared between the test, control and standard groups. In chronic models: Granuloma method was used,and test drugs were given for 7 days. The animals were divided and treated same as in the acute model. After 7 days treatment, on 8th day animalswere sacrificed each implanted pellet was extracted with adherent granulation tissue. These pellets were dried and weighed. The known weight wasdeducted from granulation tissue weight. The mean weight of granulation tissue and difference in weight of granulation tissue for each group wascalculated, and the percentage of inhibition of inflammation was calculated.Results: The percentage of inhibition of edema in the acute model with 6CH, 300CH after 3 hrs is 51%, 76% respectively and with aspirin is 79%. Inchronic models, the percentage of inhibition of granulation tissue with 6CH, 300CH after 7 days is 19.5%, 32.85%, respectively and with aspirin is41.95%. The reduction of inflammation was statistically significant in each group is (p<0.001).Conclusion: Traumeel, a homeo preparation is a best alternative drug for the treatment of acute inflammatory conditions with no side effects.Keywords: Inflammation, Traumeel preparation, Carrageenan, Aspirin.Â

Post operative wound infection: a descriptive study

Background: Surgical site infections is the third most commonly reported nosocomial infection which has an adverse impact on the hospital as well as the patient. This study was designed to evaluate the frequency, clinical presentation, common risk factors and different organisms involved. Methods: This study was performed at NRI Medical college, Chinnakakani. This is an Observational descriptive study over a period of one year from September 2022 to September 2023. Biodata of the patients together with their clinical features, diagnosis, type of surgery performed and the development of any complications including wound infection was noted and the data analyzed. Results: Out of 1509 patients in the study, 1101 belonged to obstetrics and 408 to gynaecology surgery. The overall incidence of surgical site infection in the study was 7.9%; 86 (7.8%) in obstetrics group and 33 (8%) in gynaecology group developed infection. Age more than 50 years was found to be a risk factor for postoperative wound infection. Obesity is known to be a well-established risk factor for postoperative wound infection. It was noted that surgical site infection was more common in patients that had low haemoglobin levels pre-operatively.  The increased susceptibility to infection in diabetics is an established risk factor. Conclusions: Meticulous surgical technique, proper sterilization, judicious use of antibiotics, improvement of ward environments, control of malnutrition and obesity, treatment of infective foci and diseases like diabetes helps control the morbidity of surgical wound infections

Physico-Chemical Features of Kali River, Karwar,West Coast of India

The present study was carried out for the physico-chemical characteristics of a Kali river from October 2009 to March 2010. The parameters in this study ranged between Air temp., 12.7°C to 25.3°C; Water temp.11.3°C to 19.6°C; Transparency 52.6 cm.to 76.8 cm; Turbidity 14.4 JTU to 20.7 JTU; pH 7.1 to 8.3; Total solids 492.87 mg/I; Free co2 0.98 to 9.6 mg/I; Dissolved oxygen 9.66 mg/I to 11.75 mg/I; BOD 1.20 mg/I to 4.42 mg/I and chlorides 14.89 mg/I to 21.65 mg/I for the period of study

Induction of somatic embryogenesis in different varieties of sugarcane (Saccharam officinarum L.)

This investigation for the first time highlights TDZ induced callus formation, somatic embryogenesis and plant regeneration using leaf explants of different varieties (Co94032,CoC671, Co86032, SNK754, SNK61 and SNK44) of sugarcane (Saccharam officinarum). Leaf explants cultured on the full strength inorganic salts Murashige and Skoog (1962) basal medium supplemented with 4.52 μM 2, 4-D and 4.54 μM TDZ induced embryogenic tissue after 3-4 weeks. The percentage of somatic embryogenesis was not similar in all the tested varieties of sugarcane. This study indicates a high embryogenic potential of leaf explants of tested sugarcane varieties, and also opened up the possibility for large-scale clonal propagation of sugarcane for the genetic improvement programmes