4,821 research outputs found
Counting Blessings versus Neutral Events: An Experimental Investigation of Gratitude and Athletic Performance in Volleyball
Positive psychology has related gratitude to positive outcomes for individuals. The purpose of the current study was to apply gratitude journaling to the athletic domain, specifically volleyball. It was hypothesized that participants journaling about things they were grateful for at each practice would result in heightened athletic performance, measured through vertical approach and block jump, team win/loss percentage, and satisfaction with performance, especially when compared to participants who journaled about neutral practice events. Results showed a significant difference between groups in athlete satisfaction with individual and team performance; however, participants who journaled about neutral practice events displayed higher levels of satisfaction
Analytic results for two-loop Yang-Mills
Recent Developments in computing very specific helicity amplitudes in two
loop QCD are presented. The techniques focus upon the singular structure of the
amplitude rather than on a diagramatic and integration approachComment: Talk presented at 13th International Symposium on Radiative
Corrections, 24-29 September, 2017,St. Gilgen, Austria, 9 page
Qualitative Inquiry into Church-Based Assets for HIV/AIDS Prevention and Control: A Forum Focus Group Discussion Approach
Assets church members believed they needed to engage in effective HIV/AIDS prevention and control activities. We used the three-step forum focus group discussion (FFGD) methodology to elicit responses from 32 church leaders and lay members, representing five denominations in Aba, Nigeria. Concrete resources, health expertise, finances, institutional support, capacity building, and spiritual support connected to the collective interest of members were indicated as useful for church members to engage in HIV/AIDS prevention and control activities. Adequate planning and delivery of cost-effective, appropriate and sustainable health promotion programs require an understanding of perceived church-based assets
A pilot validation in 10 European Union Member States of a point prevalence survey of healthcare-associated infections and antimicrobial use in acute hospitals in Europe, 2011
A comparison of the galaxy populations in the Coma and distant clusters: the evolution of k+a galaxies and the role of the intracluster medium
The spectroscopic properties of galaxies in the Coma cluster are compared
with those of galaxies in rich clusters at , to investigate the
evolution of the star formation history in clusters. Luminous galaxies with
and post-starburst/post-starforming (k+a) spectra which
constitute a significant fraction of galaxies in distant cluster samples are
absent in Coma, where spectacular cases of k+a spectra are found instead at
and represent a significant proportion of the cluster dwarf galaxy
population. A simple inspection of their positions on the sky indicates that
this type of galaxy does not show a preferential location within the cluster,
but the bluest and strongest-lined group of k+a's lies in projection towards
the central 1.4 Mpc of Coma and have radial velocities significantly higher
than the cluster mean. We find a striking correlation between the positions of
these young and strong post-starburst galaxies and substructure in the hot
intracluster medium (ICM) identified from {\it XMM-Newton} data, with these
galaxies lying close to the edges of two infalling substructures. This result
strongly suggests that the interaction with the dense ICM could be responsible
for the quenching of the star formation (thus creating the k+a spectrum), and
possibly, for any previous starburst. The evolution with redshift of the
luminosity distribution of k+a galaxies can be explained by a ``downsizing
effect'', with the maximum luminosity/mass of actively star-forming galaxies
infalling onto clusters decreasing at lower redshift. We discuss the possible
physical origin of this downsizing effect and the implications of our results
for current scenarios of environmental effects on the star formation in
galaxies.Comment: 21 pages, 7 figures, to appear in ApJ, version after referee's
change
No tests required : comparing traditional and dynamic predictors of programming success.
Research over the past fifty years into predictors of programming performance has yielded little improvement in the identification of at-risk students. This is possibly because research to date is based upon using static tests, which fail to reflect changes in a student's learning progress over time. In this paper, the effectiveness of 38 traditional predictors of programming performance are compared to 12 new data-driven predictors, that are based upon analyzing directly logged data, describing the programming behavior of students. Whilst few strong correlations were found between the traditional predictors and performance, an abundance of strong significant correlations based upon programming behavior were found. A model based upon two of these metrics (Watwin score and percentage of lab time spent resolving errors) could explain 56.3% of the variance in coursework results. The implication of this study is that a student's programming behavior is one of the strongest indicators of their performance, and future work should continue to explore such predictors in different teaching contexts
The Luminosity Function of Low-Redshift Abell Galaxy Clusters
We present the results from a survey of 57 low-redshift Abell galaxy clusters
to study the radial dependence of the luminosity function (LF). The dynamical
radius of each cluster, r200, was estimated from the photometric measurement of
cluster richness, Bgc. The shape of the LFs are found to correlate with radius
such that the faint-end slope, alpha, is generally steeper on the cluster
outskirts. The sum of two Schechter functions provides a more adequate fit to
the composite LFs than a single Schechter function. LFs based on the selection
of red and blue galaxies are bimodal in appearance. The red LFs are generally
flat for -22 < M_Rc < -18, with a radius-dependent steepening of alpha for M_Rc
> -18. The blue LFs contain a larger contribution from faint galaxies than the
red LFs. The blue LFs have a rising faint-end component (alpha ~ -1.7) for M_Rc
> -21, with a weaker dependence on radius than the red LFs. The dispersion of
M* was determined to be 0.31 mag, which is comparable to the median measurement
uncertainty of 0.38 mag. This suggests that the bright-end of the LF is
universal in shape at the 0.3 mag level. We find that M* is not correlated with
cluster richness when using a common dynamical radius. Also, we find that M* is
weakly correlated with BM-type such that later BM-type clusters have a brighter
M*. A correlation between M* and radius was found for the red and blue galaxies
such that M* fades towards the cluster center.Comment: Accepted for publication in ApJ, 16 pages, 4 tables, 24 figure
A Synthetic Lethality Screen Using a Focused siRNA Library to Identify Sensitizers to Dasatinib Therapy for the Treatment of Epithelial Ovarian Cancer.
Molecular targeted therapies have been the focus of recent clinical trials for the treatment of patients with recurrent epithelial ovarian cancer (EOC). The majority have not fared well as monotherapies for improving survival of these patients. Poor bioavailability, lack of predictive biomarkers, and the presence of multiple survival pathways can all diminish the success of a targeted agent. Dasatinib is a tyrosine kinase inhibitor of the Src-family kinases (SFK) and in preclinical studies shown to have substantial activity in EOC. However, when evaluated in a phase 2 clinical trial for patients with recurrent or persistent EOC, it was found to have minimal activity. We hypothesized that synthetic lethality screens performed using a cogently designed siRNA library would identify second-site molecular targets that could synergize with SFK inhibition and improve dasatinib efficacy. Using a systematic approach, we performed primary siRNA screening using a library focused on 638 genes corresponding to a network centered on EGFR, HER2, and the SFK-scaffolding proteins BCAR1, NEDD9, and EFS to screen EOC cells in combination with dasatinib. We followed up with validation studies including deconvolution screening, quantitative PCR to confirm effective gene silencing, correlation of gene expression with dasatinib sensitivity, and assessment of the clinical relevance of hits using TCGA ovarian cancer data. A refined list of five candidates (CSNK2A1, DAG1, GRB2, PRKCE, and VAV1) was identified as showing the greatest potential for improving sensitivity to dasatinib in EOC. Of these, CSNK2A1, which codes for the catalytic alpha subunit of protein kinase CK2, was selected for additional evaluation. Synergistic activity of the clinically relevant inhibitor of CK2, CX-4945, with dasatinib in reducing cell proliferation and increasing apoptosis was observed across multiple EOC cell lines. This overall approach to improving drug efficacy can be applied to other targeted agents that have similarly shown poor clinical activity
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