The Progenitors of Dwarf Spheroidal Galaxies

Dwarf spheroidal (dSph) galaxies present an evolutionary puzzle that we explore in 40 early- and late-type dwarfs in the Local Group and nearby field. Although dSphs formed stars over extended periods, today all but one are free of detectable interstellar matter (ISM), even in the Fornax dSph, where stars still formed 100 Myr ago. Combining metallicities for red giants with HI data from the literature, we show that the well-known offset in luminosity-metallicity (L-Z) relations for dSphs and dwarf irregular (dIrr) galaxies exists also when comparing only their old stellar populations: dSphs have higher mean stellar metallicities for a fixed luminosity. Evidently younger dSphs experienced more efficient enrichment than young dIrrs. Dwarf galaxies, whose locus in the L-Z diagram is consistent with that of dSphs even for baryonic luminosities, are the ``transition-type dwarfs'' Phoenix, DDO210, LGS3, Antlia, and KKR25. They have mixed dIrr/dSph morphologies, low stellar masses, low angular momentum, and HI contents of less than a few 10^6 solar masses. Unlike dIrrs, many transition-type dwarfs would closely resemble dSphs if their gas were removed; they are likely dSph progenitors. As gas removal is key, we consider the empirical evidence for various gas removal processes. We suggest that internal gas removal mechanisms are inadequate and favor ram pressure stripping to make dSphs. A combination of initial conditions and environment seems to support the formation of dSphs, which appear to form from small galaxies with active early star formation, whose evolution halts due to externally induced gas loss. Transition-type dwarfs then are dSphs that kept their ISM, and therefore should replace dSphs in isolated locations where stripping is ineffective. (Abridged)Comment: 25 pages in AASTeX two-column preprint style, 1 table, 3 figures. Accepted for publication in the Astronomical Journal (April 2003 issue

Ancient Yersinia pestis genomes from across Western Europe reveal early diversification during the First Pandemic (541–750)

The first historically documented pandemic caused by Yersinia pestis began as the Justinianic Plague in 541 within the Roman Empire and continued as the so-called First Pandemic until 750. Although paleogenomic studies have previously identified the causative agent as Y. pestis, little is known about the bacterium’s spread, diversity, and genetic history over the course of the pandemic. To elucidate the microevolution of the bacterium during this time period, we screened human remains from 21 sites in Austria, Britain, Germany, France, and Spain for Y. pestis DNA and reconstructed eight genomes. We present a methodological approach assessing single-nucleotide polymorphisms (SNPs) in ancient bacterial genomes, facilitating qualitative analyses of low coverage genomes from a metagenomic background. Phylogenetic analysis on the eight reconstructed genomes reveals the existence of previously undocumented Y. pestis diversity during the sixth to eighth centuries, and provides evidence for the presence of multiple distinct Y. pestis strains in Europe. We offer genetic evidence for the presence of the Justinianic Plague in the British Isles, previously only hypothesized from ambiguous documentary accounts, as well as the parallel occurrence of multiple derived strains in central and southern France, Spain, and southern Germany. Four of the reported strains form a polytomy similar to others seen across the Y. pestis phylogeny, associated with the Second and Third Pandemics. We identified a deletion of a 45-kb genomic region in the most recent First Pandemic strains affecting two virulence factors, intriguingly overlapping with a deletion found in 17th- to 18th-century genomes of the Second Pandemic. © 2019 National Academy of Sciences. All rights reserved

Leo V: A Companion of a Companion of the Milky Way Galaxy

We report the discovery of a new Milky Way dwarf spheroidal galaxy in the constellation of Leo identified in data from the Sloan Digital Sky Survey. Leo V lies at a distance of about 180 kpc, and is separated by about 3 degrees from another recent discovery, Leo IV. We present follow-up imaging from the Isaac Newton Telescope and spectroscopy from the Hectochelle fiber spectrograph at the Multiple Mirror Telescope. Leo V's heliocentric velocity is 173.4 km/s, which is offset by about 40 km/s from that of Leo IV. A simple interpretation of the kinematic data is that both objects may lie on the same stream, though the implied orbit is only modestly eccentric (e = 0.2)Comment: Submitted to ApJ (Letters

The SPLASH Survey: A Spectroscopic Analysis of the Metal-Poor, Low-Luminosity M31 dSph Satellite Andromeda X

Andromeda X (And X) is a newly discovered low-luminosity M31 dwarf spheroidal galaxy (dSph) found by Zucker et al. (2007) in the Sloan Digital Sky Survey (SDSS - York et al. 2000). In this paper, we present the first spectroscopic study of individual red giant branch stars in And X, as a part of the SPLASH Survey (Spectroscopic and Photometric Landscape of Andromeda's Stellar Halo). Using the Keck II telescope and multiobject DEIMOS spectrograph, we target two spectroscopic masks over the face of the galaxy and measure radial velocities for ~100 stars with a median accuracy of sigma_v ~ 3 km/s. The velocity histogram for this field confirms three populations of stars along the sight line: foreground Milky Way dwarfs at small negative velocities, M31 halo red giants over a broad range of velocities, and a very cold velocity ``spike'' consisting of 22 stars belonging to And X with v_rad = -163.8 +/- 1.2 km/s. By carefully considering both the random and systematic velocity errors of these stars (e.g., through duplicate star measurements), we derive an intrinsic velocity dispersion of just sigma_v = 3.9 +/- 1.2 km/s for And X, which for its size, implies a minimum mass-to-light ratio of M/L =37^{+26}_{-19} assuming the mass traces the light. Based on the clean sample of member stars, we measure the median metallicity of And X to be [Fe/H] = -1.93 +/- 0.11, with a slight radial metallicity gradient. The dispersion in metallicity is large, sigma([Fe/H]) = 0.48, possibly hinting that the galaxy retained much of its chemical enrichment products. We discuss the potential for better understanding the formation and evolution mechanisms for M31's system of dSphs through (current) kinematic and chemical abundance studies, especially in relation to the Milky Way sample. (abridged version)Comment: Accepted for Publication in Astrophys. J. 14 pages including 7 figures and 2 tables (journal format

The ACS LCID Project. I. Short-Period Variables in the Isolated Dwarf Spheroidal Galaxies Cetus & Tucana

(abridged) We present the first study of the variable star populations in the isolated dwarf spheroidal galaxies (dSph) Cetus and Tucana. Based on Hubble Space Telescope images obtained with the Advanced Camera for Surveys in the F475W and F814W bands, we identified 180 and 371 variables in Cetus and Tucana, respectively. The vast majority are RR Lyrae stars. In Cetus we also found three anomalous Cepheids, four candidate binaries and one candidate long-period variable (LPV), while six anomalous Cepheids and seven LPV candidates were found in Tucana. Of the RR Lyrae stars, 147 were identified as fundamental mode (RRab) and only eight as first-overtone mode (RRc) in Cetus, with mean periods of 0.614 and 0.363 day, respectively. In Tucana we found 216 RRab and 82 RRc giving mean periods of 0.604 and 0.353 day. These values place both galaxies in the so-called Oosterhoff Gap, as is generally the case for dSph. We calculated the distance modulus to both galaxies using different approaches based on the properties of RRab and RRc, namely the luminosity-metallicity and period-luminosity-metallicity relations, and found values in excellent agreement with previous estimates using independent methods: (m-M)_{0,Cet}=24.46+-0.12 and (m-M)_{0,Tuc}=24.74+-0.12, corresponding to 780+-40 kpc and 890+-50 kpc. We also found numerous RR Lyrae variables pulsating in both modes simultaneously (RRd): 17 in Cetus and 60 in Tucana. Tucana is, after Fornax, the second dSph in which such a large fraction of RRd (~17%) has been observed. We provide the photometry and pulsation parameters for all the variables, and compare the latter with values from the literature for well-studied dSph of the Local Group and Galactic globular clusters.Comment: 26 pages, 24 figures, in emulateapj format. To be published in ApJ. Some figures heavily degraded; See http://www.iac.es/project/LCID/?p=publications for a version with full resolution figure

Variable Stars in the Cetus dSph Galaxy: Population Gradients and Connections with the Star Formation History

We investigate the variable star content of the isolated, Local Group, dwarf spheroidal galaxy (dSph) Cetus. Multi-epoch, wide-field images collected with the VLT/VIMOS camera allowed us to detect 638 variable stars (630 RR Lyrae stars and 8 Anomalous Cepheids), 475 of which are new detections. We present a full catalogue of periods, amplitudes, and mean magnitudes. Motivated by the recent discovery that the pulsational properties of the RR Lyrae stars in the Tucana dSph revealed the presence of a metallicity gradient within the oldest (>10 Gyr old) stellar populations, we investigated the possibility of an analogous effect in Cetus. We found that, despite the obvious radial gradient in the Horizontal Branch (HB) and Red Giant Branch (RGB) morphologies, both becoming bluer on average for increasing distance from the center of Cetus, the properties of the RR Lyrae stars are homogeneous within the investigated area (out to r~15'), with no significant evidence of a radial gradient. We discuss this in connection with the star formation history (SFH) previously derived for the two galaxies. The observed differences between these two systems show that even systems this small show a variety of early evolutionary histories. These differences could be due to different merger or accretion histories.Comment: Accepted for publication on MNRAS. The complete set of light curves and finding charts, together with the full table of the pulsational properties of all variable stars will be available in the on-line edition of the pape

Dark Matter and Stellar Mass in the Luminous Regions of Disk Galaxies

We investigate the correlations among stellar mass (M_*), disk scale length (R_d), and rotation velocity at 2.2 disk scale lengths (V_2.2) for a sample of 81 disk-dominated galaxies (disk/total >= 0.9) selected from the SDSS. We measure V_2.2 from long-slit H-alpha rotation curves and infer M_* from galaxy i-band luminosities (L_i) and g-r colors. We find logarithmic slopes of 2.60+/-0.13 and 3.05+/-0.12 for the L_i-V_2.2 and M_*-V_2.2 relations, somewhat shallower than most previous studies, with intrinsic scatter of 0.13 dex and 0.16 dex. Our direct estimates of the total-to-stellar mass ratio within 2.2R_d, assuming a Kroupa IMF, yield a median ratio of 2.4 for M_*>10^10 Msun and 4.4 for M_*=10^9-10^10 Msun, with large scatter at a given M_* and R_d. The typical ratio of the rotation speed predicted for the stellar disk alone to the observed rotation speed at 2.2R_d is ~0.65. The distribution of R_d at fixed M_* is broad, but we find no correlation between disk size and the residual from the M_*-V_2.2 relation, implying that this relation is an approximately edge-on view of the disk galaxy fundamental plane. Independent of the assumed IMF, this result implies that stellar disks do not, on average, dominate the mass within 2.2R_d. We discuss our results in the context of infall models of disk formation in cold dark matter halos. A model with a disk-to-halo mass ratio m_d=0.05 provides a reasonable match to the R_d-M_* distribution for spin parameters \lambda ranging from ~0.04-0.08, and it yields a reasonable match to the mean M_*-V_2.2 relation. A model with m_d=0.1 predicts overly strong correlations between disk size and M_*-V_2.2 residual. Explaining the wide range of halo-to-disk mass ratios within 2.2R_d requires significant scatter in m_d values, with systematically lower m_d for galaxies with lower $M_*$.Comment: 18 pages, 2 tables, 7 figures, Accepted to ApJ, Table 1 updated, otherwise minor change

Piecing together the puzzle of NGC 5253: abundances, kinematics and WR stars

We present Gemini-S/GMOS-IFU optical spectroscopy of four regions near the centre of the nearby (3.8 Mpc) dwarf starburst galaxy NGC 5253. This galaxy is famous for hosting a radio supernebula containing two deeply embedded massive super star clusters, surrounded by a region of enhanced nitrogen abundance that has been linked to the presence of WR stars. We detected 11 distinct sources of red WR bump (CIV) emission over a 20" (~350 pc) area, each consistent with the presence of ~1 WCE-type star. WC stars are not found coincident with the supernebula, although WN stars have previously been detected here. We performed a multi-component decomposition of the H\alpha\ line across all four fields and mapped the kinematics of the narrow and broad (FWHM = 100-250 km/s) components. These maps paint a picture of localised gas flows, as part of multiple overlapping bubbles and filaments driven by the star clusters throughout the starburst. We confirm the presence of a strong H\alpha\ velocity gradient over ~4.5" (~80 pc) coincident with the region of N/O enhancement, and high gas density known from previous study, and interpret this as an accelerating ionized gas outflow from the supernebula clusters. We measure the ionized gas abundances in a number of regions in the outer IFU positions and combine these with measurements from the literature to assess the radial abundance distribution. We find that the O/H and N/H profiles are consistent with being flat. Only the central 50 pc exhibits the well-known N/O enhancement, and we propose that the unusually high densities/pressures in the supernebula region have acted to impede the escape of metal-enriched hot winds from the star clusters and allow them to mix with the cooler phases, thus allowing these freshly processed chemicals to be seen in the optical.Comment: 16 pages, accepted to A&

The ACS LCID project. VI. The SFH of the Tucana dSph and the relative ages of the isolated dSph galaxies

We present a detailed study of the star formation history (SFH) of the Tucana dwarf spheroidal galaxy. High quality, deep HST/ACS data, allowed us to obtain the deepest color-magnitude diagram to date, reaching the old main sequence turnoff (F814 ~ 29) with good photometric accuracy. Our analysis, based on three different SFH codes, shows that Tucana is an old and metal-poor stellar system, which experienced a strong initial burst of star formation at a very early epoch (~ 13 Gyr ago) which lasted a maximum of 1 Gyr (sigma value). We are not able to unambiguously answer the question of whether most star formation in Tucana occurred before or after the end of the reionization era, and we analyze alternative scenarios that may explain the transformation of Tucana from a gas-rich galaxy into a dSph. Current measurements of its radial velocity do not preclude that Tucana may have crossed the inner regions of the Local Group once, and so gas stripping by ram pressure and tides due to a close interaction cannot be ruled out. On the other hand, the high star formation rate measured at early times may have injected enough energy into the interstellar medium to blow out a significant fraction of the initial gas content. Gas that is heated but not blown out would also be more easily stripped via ram pressure. We compare the SFH inferred for Tucana with that of Cetus, the other isolated LG dSph galaxy in the LCID sample. We show that the formation time of the bulk of star formation in Cetus is clearly delayed with respect to that of Tucana. This reinforces the conclusion of Monelli et al. (2010) that Cetus formed the vast majority of its stars after the end of the reionization era implying, therefore, that small dwarf galaxies are not necessarily strongly affected by reionization, in agreement with many state-of-the-art cosmological models. [abridged]Comment: Accepted for publication on ApJ, 19 pages, 10 figures, 2 tables. A version with full resolution figures is available at http://www.iac.es/project/LCID/?p=publication

HAGE (DDX43) is a biomarker for poor prognosis and a predictor of chemotherapy response in breast cancer

Background: HAGE protein is a known immunogenic cancer-specific antigen. Methods: The biological, prognostic and predictive values of HAGE expression was studied using immunohistochemistry in three cohorts of patients with BC (n=2147): early primary (EP-BC; n=1676); primary oestrogen receptor-negative (PER-BC; n=275) treated with adjuvant anthracycline-combination therapies (Adjuvant-ACT); and primary locally advanced disease (PLA-BC) who received neo-adjuvant anthracycline-combination therapies (Neo-adjuvant-ACT; n=196). The relationship between HAGE expression and the tumour-infiltrating lymphocytes (TILs) in matched prechemotherapy and postchemotherapy samples were investigated. Results: Eight percent of patients with EP-BC exhibited high HAGE expression (HAGEþ) and was associated with aggressive clinico-pathological features (Ps<0.01). Furthermore, HAGEþexpression was associated with poor prognosis in both univariate and multivariate analysis (Ps<0.001). Patients with HAGE+ did not benefit from hormonal therapy in high-risk ER-positive disease. HAGE+ and TILs were found to be independent predictors for pathological complete response to neoadjuvant-ACT; P<0.001. A statistically significant loss of HAGE expression following neoadjuvant-ACT was found (P=0.000001), and progression-free survival was worse in those patients who had HAGE+ residual disease (P=0.0003). Conclusions: This is the first report to show HAGE to be a potential prognostic marker and a predictor of response to ACT in patients with BC