EFFECTS OF FORAGE QUALITY RESTRICTIONS ON OPTIMAL PRODUCTION SYSTEMS DETERMINED BY LINEAR PROGRAMMING

Livestock Production/Industries,

The relevance of ERTS-1 data to the state of Ohio

There are no author-identified significant results in this report

Tonic inhibition of accumbal spiny neurons by extrasynaptic 4 GABAA receptors modulates the actions of psychostimulants

Within the nucleus accumbens (NAc), synaptic GABAA receptors (GABAARs) mediate phasic inhibition of medium spiny neurons (MSNs) and influence behavioral responses to cocaine. We demonstrate that both dopamine D1- and D2-receptor-expressing MSNs (D-MSNs) additionally harbor extrasynaptic GABAARs incorporating α4, β, and δ subunits that mediate tonic inhibition, thereby influencing neuronal excitability. Both the selective δ-GABAAR agonist THIP and DS2, a selective positive allosteric modulator, greatly increased the tonic current of all MSNs from wild-type (WT), but not from δ−/− or α4−/− mice. Coupling dopamine and tonic inhibition, the acute activation of D1 receptors (by a selective agonist or indirectly by amphetamine) greatly enhanced tonic inhibition in D1-MSNs but not D2-MSNs. In contrast, prolonged D2 receptor activation modestly reduced the tonic conductance of D2-MSNs. Behaviorally, WT and constitutive α4−/− mice did not differ in their expression of cocaine-conditioned place preference (CPP). Importantly, however, mice with the α4 deletion specific to D1-expressing neurons (α4D1−/−) showed increased CPP. Furthermore, THIP administered systemically or directly into the NAc of WT, but not α4−/− or α4D1−/− mice, blocked cocaine enhancement of CPP. In comparison, α4D2−/− mice exhibited normal CPP, but no cocaine enhancement. In conclusion, dopamine modulation of GABAergic tonic inhibition of D1- and D2-MSNs provides an intrinsic mechanism to differentially affect their excitability in response to psychostimulants and thereby influence their ability to potentiate conditioned reward. Therefore, α4βδ GABAARs may represent a viable target for the development of novel therapeutics to better understand and influence addictive behaviors

SenseMap: Supporting Browser-based Online Sensemaking through Analytic Provenance

Sensemaking is described as the process in which people collect, organize and create representations of information, all centered around some problem they need to understand. People often get lost when solving complicated tasks using big datasets over long periods of exploration and analysis. They may forget what they have done, are unaware of where they are in the context of the overall task, and are unsure where to continue. In this paper, we introduce a tool, SenseMap, to address these issues in the context of browser-based online sensemaking. We conducted a semistructured interview with nine participants to explore their behaviors in online sensemaking with existing browser functionality. A simplified sensemaking model based on Pirolli and Card’s model is derived to better represent the behaviors we found: users iteratively collect information sources relevant to the task, curate them in a way that makes sense, and finally communicate their findings to others. SenseMap automatically captures provenance of user sensemaking actions and provides multi-linked views to visualize the collected information and enable users to curate and communicate their findings. To explore how SenseMap is used, we conducted a user study in a naturalistic work setting with five participants completing the same sensemaking task related to their daily work activities. All participants found the visual representation and interaction of the tool intuitive to use. Three of them engaged with the tool and produced successful outcomes. It helped them to organize information sources, to quickly find and navigate to the sources they wanted, and to effectively communicate their findings

Genome-wide association studies for feedlot and growth traits in cattle

A genome wide-association study for production traits in cattle was carried out using genotype data from the 10K Affymetrix (Santa Clara, CA) and the 50K Illumina (San Diego, CA) SNP chips. The results for residual feed intake (RFI), BW, and hip height in 3 beef breed types (Bos indicus, Bos taurus, and B. indicus × B. taurus), and for stature in dairy cattle, are presented. The aims were to discover SNP associated with all traits studied, but especially RFI, and further to test the consistency of SNP effects across different cattle populations and breed types. The data were analyzed within data sets and within breed types by using a mixed model and fitting 1 SNP at a time. In each case, the number of significant SNP was more than expected by chance alone. A total of 75 SNP from the reference population with 50K chip data were significant (P < 0.001) for RFI, with a false discovery rate of 68%. These 75 SNP were mapped on 24 different BTA. Of the 75 SNP, the 9 most significant SNP were detected on BTA 3, 5, 7, and 8, with P ≤ 6.0 × 10 . In a population of Angus cattle divergently selected for high and low RFI and 10K chip data, 111 SNP were significantly (P < 0.001) associated with RFI, with a false discovery rate of 7%. Approximately 103 of these SNP were therefore likely to represent true positives. Because of the small number of SNP common to both the 10K and 50K SNP chips, only 27 SNP were significantly (P < 0.05) associated with RFI in the 2 populations. However, other chromosome regions were found that contained SNP significantly associated with RFI in both data sets, although no SNP within the region showed a consistent effect on RFI. The SNP effects were consistent between data sets only when estimated within the same breed type

Drought Feeding Management

Guidelines for feeding cattle during drough

Water-Damaged Feed Considerations.

2 p

Mineral Supplementation of Beef Cows in Texas

The proper balance of protein, energy, vitamins and all nutritionally important minerals is needed to make a successful nutrition program, one that's productive yet economical. Nutrient balance is the key to any effective nutrition program, especially where trace minerals are concerned

The changing of the guard: groupwork with people who have intellectual disabilities

This paper considers the impact of service systems on group activities. It describes an inter-professional groupwork project facilitated by a social worker and a community nurse. The project provided an emancipatory experience for a group of adults who had intellectual disabilities. The group was charged with the task of reviewing and updating the recruitment and interview processes used by a 'Learning Disability Partnership Board', when employing new support workers. The paper begins with a brief history of intellectual disability and provides a context to the underpinning philosophical belief that people should be encouraged and supported to inhabit valued social roles no matter what disability they may have. It then identifies the ways in which the sponsoring health, education and social care services impacted on the creation and development of a groupwork project. It might have been expected that the nature of the intellectual disability would have been the major influence on group process. However the paper reveals that organisational constraints had a significant impact on group functioning. Issues including, staffing budgets and transport contracts impacted on group process and function. The results of the project show how, with adequate support, people with intellectual disability can make important decisions that have long-reaching impacts on the services