Fast determination of coarse grained cell anisotropy and size in epithelial tissue images using Fourier transform

Mechanical strain and stress play a major role in biological processes such as wound healing or morphogenesis. To assess this role quantitatively, fixed or live images of tissues are acquired at a cellular precision in large fields of views. To exploit these data, large numbers of cells have to be analyzed to extract cell shape anisotropy and cell size. Most frequently, this is performed through detailed individual cell contour determination, using so-called segmentation computer programs, complemented if necessary by manual detection and error corrections. However, a coarse grained and faster technique can be recommended in at least three situations. First, when detailed information on individual cell contours is not required, for instance in studies which require only coarse-grained average information on cell anisotropy. Second, as an exploratory step to determine whether full segmentation can be potentially useful. Third, when segmentation is too difficult, for instance due to poor image quality or too large a cell number. We developed a user-friendly, Fourier transform-based image analysis pipeline. It is fast (typically $10^4$ cells per minute with a current laptop computer) and suitable for time, space or ensemble averages. We validate it on one set of artificial images and on two sets of fully segmented images, one from a Drosophila pupa and the other from a chicken embryo; the pipeline results are robust. Perspectives include \textit{in vitro} tissues, non-biological cellular patterns such as foams, and $xyz$ stacks.Comment: 13 pages; 9 figure

Concurrent 43 and 86 GHz Very Long Baseline Polarimetry of 3C273

We present sub-milliarcsecond resolution total intensity and linear polarization VLBI images of 3C273, using concurrent 43 and 86 GHz data taken with the Very Long Baseline Array in May 2002. The structure seen in the innermost jet suggest that we have fortuitously caught the jet in the act of changing direction. The polarization images confirm that the core is unpolarized (fractional polarization m < 1 %) at 86 GHz, but also show well ordered magnetic fields (m ~ 15 %) in the inner jet, at a projected distance of 2.3 pc from the core. In this strongly polarized region, the rotation measure changes across the jet by 4.2 x 10^{4} rad m^{-2} over an angular width of about 0.3 milliarcseconds. If the lack of polarization in the core is also attributed to a Faraday screen, then a rotation measure dispersion > 5.2 x 10^{4} rad m^{-2} must be present in or in front of that region. These are among the highest rotation measures reported so far in the nucleus of any active galaxy or quasar, and must occur outside (but probably close to) the radio emitting region. The transverse rotation measure gradient is in the same sense as that observed by Asada et al and by Zavala and Taylor at greater core distances. The magnitude of the transverse gradient decreases rapidly with distance down the jet, and appears to be variable.Comment: 4 pages, LaTeX, 3 postscript figures, submitted to Astrophysical Journal Letter

Discovery of two simultaneous non-harmonically related Quasi-Periodic Oscillations in the 2005 outburst of the black-hole binary GRO J1655-40

We studied the low-frequency quasi-periodic oscillations (LFQPOs) in the black hole GRO J1655-40 during the 2005 outburst, using data from the Rossi X-ray Timing Explorer. All LFQPOs could be identified as either type B or type C using previously proposed classification schemes. In the soft state of the outburst the type-C LFQPOs reached frequencies that are among the highest ever seen for LFQPOs in black holes. At the peak of the outburst, in the ultra-luminous state, the power spectrum showed two simultaneous, non-harmonically related peaks which we identified as a type-B and a type-C QPO. The simultaneous presence of a type-C and type-B QPO shows that at least two of the three known LFQPO types are intrinsically different and likely the result of distinct physical mechanisms. We also studied the properties of a broad peaked noise component in the power spectra of the ultra-luminous state. This noise component becomes more coherent with count rate and there are strong suggestions that it evolves into a type-B QPO at the highest observed count rates.Comment: 14 pages, 6 figures, 2 tables, accepted for publication in MNRA

The health and welfare of rural and urban cancer survivors in Missouri

INTRODUCTION: An estimated 2.8 million cancer survivors reside in rural areas in the United States. We compared the risk behaviors, psychosocial factors, health outcomes, quality of life, and follow-up care of rural and urban cancer survivors in Missouri. METHODS: We used 2009–2010 Missouri Behavioral Risk Factor Surveillance System data to examine various health outcomes, behaviors, and psychosocial factors among rural and urban cancer survivors and their respective rural and urban counterparts without a cancer history. Cancer survivors also were asked about receipt of survivorship care plan components. Sociodemographic factors, access to medical care, and chronic conditions were examined as potential explanatory factors for differences among the 4 groups. RESULTS: An estimated 9.4% of rural and 7.9% of urban Missourians aged 18 years or older reported a cancer history. Rural survivors reported the highest rates of poor self-reported health, physical distress, and activity limitation; however differences between rural and urban survivors were attributable largely to sociodemographic differences. Both rural and urban cancer survivors reported more fatigue than their respective counterparts without a cancer history. Rural survivors also were less likely to meet Centers for Disease Control and Prevention recommendations for physical activity than their rural controls. The prevalence of smoking among rural survivors was higher than among urban survivors. Only 62% of rural survivors versus 78% of urban survivors reported receiving advice about cancer follow-up care. CONCLUSION: Rural cancer survivors face many health challenges. Interventions to improve quality of life and health behaviors should be adapted to meet the needs of rural cancer survivors

CTMC calculations of electron capture and ionization in collisions of multiply charged ions with elliptical Rydberg atoms

We have performed classical trajectory Monte Carlo (CTMC) studies of electron capture and ionization in multiply charged (Q=8) ion-Rydberg atom collisions at intermediate impact velocities. Impact parallel to the minor and to the major axis, respectively, of the initial Kepler electron ellipse has been investigated. The important role of the initial electron momentum distribution found for singly charged ion impact is strongly disminished for higher projectile charge, while the initial spatial distribution remains important for all values of Q studied.Comment: 3 pages, 5 figure

Optical Monitoring of PKS 1510-089: A Binary Black Hole System?

Three deep flux minima were observed with nearly the same time-scales and intervals for the blazar PKS 1510-089 in the past few years. A binary black hole system was proposed to be at the nucleus of this object, and a new minimum was predicted to occur in 2002 March. We monitored this source with a 60/90 cm Schmidt telescope from 2002 February to April. In combination with the data obtained by Xie et al. (2004) in the same period, we presented for the 2002 minimum a nearly symmetric light curve, which would be required by an eclipsing model of a binary black hole system. We also constrained the time-scale of the minimum to be 35 min, which is more consistent with the time-scales ~42 min of the three previous minima than the 89 min time-scale given by the same authors. The wiggling miniarcsecond radio jet observed in this object is taken as a further evidence for the binary black hole system. The `coupling' of the periodicity in light curve and the helicity in radio jet is discussed in the framework of a binary black hole system.Comment: 5 pages, 4 figures, accepted by MNRA

A Persistent Disk Wind in GRS 1915+105 with NICER

The bright, erratic black hole X-ray binary GRS 1915+105 has long been a target for studies of disk instabilities, radio/infrared jets, and accretion disk winds, with implications that often apply to sources that do not exhibit its exotic X-ray variability. With the launch of NICER, we have a new opportunity to study the disk wind in GRS 1915+105 and its variability on short and long timescales. Here we present our analysis of 39 NICER observations of GRS 1915+105 collected during five months of the mission data validation and verification phase, focusing on Fe XXV and Fe XXVI absorption. We report the detection of strong Fe XXVI in 32 (>80%) of these observations, with another four marginal detections; Fe XXV is less common, but both likely arise in the well-known disk wind. We explore how the properties of this wind depends on broad characteristics of the X-ray lightcurve: mean count rate, hardness ratio, and fractional RMS variability. The trends with count rate and RMS are consistent with an average wind column density that is fairly steady between observations but varies rapidly with the source on timescales of seconds. The line dependence on spectral hardness echoes known behavior of disk winds in outbursts of Galactic black holes; these results clearly indicate that NICER is a powerful tool for studying black hole winds.Comment: Accepted for publication in ApJL. Comments welcom

Nonlinear coherent transport of waves in disordered media

We present a diagrammatic theory for coherent backscattering from disordered dilute media in the nonlinear regime. The approach is non-perturbative in the strength of the nonlinearity. We show that the coherent backscattering enhancement factor is strongly affected by the nonlinearity, and corroborate these results by numerical simulations. Our theory can be applied to several physical scenarios like scattering of light in nonlinear Kerr media, or propagation of matter waves in disordered potentials.Comment: 4 pages, 3 figure

Polarised infrared emission from X-ray binary jets

Near-infrared (NIR) and optical polarimetric observations of a selection of X-ray binaries are presented. The targets were observed using the Very Large Telescope and the United Kingdom Infrared Telescope. We detect a significant level (3 sigma) of linear polarisation in four sources. The polarisation is found to be intrinsic (at the > 3 sigma level) in two sources; GRO J1655-40 (~ 4-7% in H and Ks-bands during an outburst) and Sco X-1 (~ 0.1-0.9% in H and K), which is stronger at lower frequencies. This is likely to be the signature of optically thin synchrotron emission from the collimated jets in these systems, whose presence indicates a partially-ordered magnetic field is present at the inner regions of the jets. In Sco X-1 the intrinsic polarisation is variable (and sometimes absent) in the H and K-bands. In the J-band (i.e. at higher frequencies) the polarisation is not significantly variable and is consistent with an interstellar origin. The optical light from GX 339-4 is also polarised, but at a level and position angle consistent with scattering by interstellar dust. The other polarised source is SS 433, which has a low level (0.5-0.8%) of J-band polarisation, likely due to local scattering. The NIR counterparts of GRO J0422+32, XTE J1118+480, 4U 0614+09 and Aql X-1 (which were all in or near quiescence) have a linear polarisation level of < 16% (3 sigma upper limit, some are < 6%). We discuss how such observations may be used to constrain the ordering of the magnetic field close to the base of the jet in such systems.Comment: Accepted to be published in MNRAS; 13 pages, 6 figure