Producao de ovos de vermes gastrintestinais em vacas Nelore, durante o periodo periparto.

bitstream/item/138554/1/COT-27.pdfCNPGC

Avaliação preliminar de parâmetros epidemiológicos da tristeza parasitaria bovina no Mato Grosso do Sul.

Epidemiologia; Bovino; Tristeza parasitaria; Praga; Sanidade; America do Sul; Brasil; Mato Grosso do Sul.bitstream/item/137587/1/PESQ-EM-ANDAMENTO-38.pdfCNPGC

Identificação das espécies e a resistência de parasitos gastrintestinais de ovinos a anti-helmínticos em Mato Grosso do Sul.

bitstream/item/139529/1/COT-108.pd

Epidemiologia dos nematódeos gastrintestinais em bovinos de corte nos cerrados e o controle estratégico no Brasil.

Prevalência das espécies. OPG e imunidade adquirida. Larvas na pastagem. Hipobiose. Mortalidade de animais. Integração entre os helmintos do abomaso. Anorexia. Faixa etária, prejuízos e controle. Custo/Benefício.bitstream/item/104809/1/Epidemiologia-dos-nematoideos-gastrintestinais.pd

Observation of mesoscopic crystalline structures in a two-dimensional Rydberg gas

The ability to control and tune interactions in ultracold atomic gases has paved the way towards the realization of new phases of matter. Whereas experiments have so far achieved a high degree of control over short-ranged interactions, the realization of long-range interactions would open up a whole new realm of many-body physics and has become a central focus of research. Rydberg atoms are very well-suited to achieve this goal, as the van der Waals forces between them are many orders of magnitude larger than for ground state atoms. Consequently, the mere laser excitation of ultracold gases can cause strongly correlated many-body states to emerge directly when atoms are transferred to Rydberg states. A key example are quantum crystals, composed of coherent superpositions of different spatially ordered configurations of collective excitations. Here we report on the direct measurement of strong correlations in a laser excited two-dimensional atomic Mott insulator using high-resolution, in-situ Rydberg atom imaging. The observations reveal the emergence of spatially ordered excitation patterns in the high-density components of the prepared many-body state. They have random orientation, but well defined geometry, forming mesoscopic crystals of collective excitations delocalised throughout the gas. Our experiment demonstrates the potential of Rydberg gases to realise exotic phases of matter, thereby laying the basis for quantum simulations of long-range interacting quantum magnets.Comment: 10 pages, 7 figure

Znf202 Affects High Density Lipoprotein Cholesterol Levels and Promotes Hepatosteatosis in Hyperlipidemic Mice

Background: The zinc finger protein Znf202 is a transcriptional suppressor of lipid related genes and has been linked to hypoalphalipoproteinemia. A functional role of Znf202 in lipid metabolism in vivo still remains to be established. Methodology and Principal Findings: We generated mouse Znf202 expression vectors, the functionality of which was established in several in vitro systems. Next, effects of adenoviral znf202 overexpression in vivo were determined in normo- as well as hyperlipidemic mouse models. Znf202 overexpression in mouse hepatoma cells mhAT3F2 resulted in downregulation of members of the Apoe/c1/c2 and Apoa1/c3/a4 gene cluster. The repressive activity of Znf202 was firmly confirmed in an apoE reporter assay and Znf202 responsive elements within the ApoE promoter were identified. Adenoviral Znf202 transfer to Ldlr-/- mice resulted in downregulation of apoe, apoc1, apoa1, and apoc3 within 24 h after gene transfer. Interestingly, key genes in bile flux (abcg5/8 and bsep) and in bile acid synthesis (cyp7a1) were also downregulated. At 5 days post-infection, the expression of the aforementioned genes was normalized, but mice had developed severe hepatosteatosis accompanied by hypercholesterolemia and hypoalphalipoproteinemia. A much milder phenotype was observed in wildtype mice after 5 days of hepatic Znf202 overexpression. Interestingly and similar to Ldl-/- mice, HDL-cholesterol levels in wildtype mice were lowered after hepatic Znf202 overexpression. Conclusion/Significance: Znf202 overexpression in vivo reveals an important role of this transcriptional regulator in liver lipid homeostasis, while firmly establishing the proposed key role in the control of HDL levels

Produção de ovos de nematódeos gastrintestinais em vacas nelore, durante o período periparto.

Foi avaliada a influencia das epocas de pre e pos-parto sobre a contagem de ovos de mematodeos nas fezes de bovinos de corte. Utilizaram-se 32 vacas Nelore prenhes, sendo 8 de primeira, 12 de segunda e 12 de terceira cria, com o parto previstao para o mes de outubro. Para determinacao do numero de ovoso por grama de fezes (OPG) e coproculturas, foi feita uma coleta de fezes antes do parto (aproximadamente quinze dias antes), uma por ocasiao do parto e seis coletas semanais apos o parto. Nao houve interacao significativa entre o numero de crias das vacas com os valores de OPG nas diferentes coletas. Nao foi observada diferenca significativa, nos valores de OPG, antes e depois do parto, apesar de ter havido uma tendencia de aumento no dia do parto, e nas duassemanas apos o parto. As vacas de primeira cria apresentaram media de OPG maiores do que as vacas de segunda e terceira crias, tanto antes como depois do parto (P<0,05). A Cooperia foi o nematodeo que mais contribuiu para o aumento de OPG. Levando-se em consideracoes o aumento de OPG das vacas e estudos epidemiologicos anteriores, e recomendada a dosificacao das vacas no mes de julho ou agosto.Título em inglês: The production of eggs by gastrointestinal nematodes in Nellore cows, during the peri-parturient period

Mouse models of neurodegenerative disease: preclinical imaging and neurovascular component.

Neurodegenerative diseases represent great challenges for basic science and clinical medicine because of their prevalence, pathologies, lack of mechanism-based treatments, and impacts on individuals. Translational research might contribute to the study of neurodegenerative diseases. The mouse has become a key model for studying disease mechanisms that might recapitulate in part some aspects of the corresponding human diseases. Neurode- generative disorders are very complicated and multifacto- rial. This has to be taken in account when testing drugs. Most of the drugs screening in mice are very di cult to be interpretated and often useless. Mouse models could be condiderated a ‘pathway models’, rather than as models for the whole complicated construct that makes a human disease. Non-invasive in vivo imaging in mice has gained increasing interest in preclinical research in the last years thanks to the availability of high-resolution single-photon emission computed tomography (SPECT), positron emission tomography (PET), high eld Magnetic resonance, Optical Imaging scanners and of highly speci c contrast agents. Behavioral test are useful tool to characterize di erent ani- mal models of neurodegenerative pathology. Furthermore, many authors have observed vascular pathological features associated to the di erent neurodegenerative disorders. Aim of this review is to focus on the di erent existing animal models of neurodegenerative disorders, describe behavioral tests and preclinical imaging techniques used for diagnose and describe the vascular pathological features associated to these diseases