A Novel Method for Epileptic Seizure Detection Using Coupled Hidden Markov Models

We propose a novel Coupled Hidden Markov Model to detect epileptic seizures in multichannel electroencephalography (EEG) data. Our model defines a network of seizure propagation paths to capture both the temporal and spatial evolution of epileptic activity. To address the intractability introduced by the coupled interactions, we derive a variational inference procedure to efficiently infer the seizure evolution from spectral patterns in the EEG data. We validate our model on EEG aquired under clinical conditions in the Epilepsy Monitoring Unit of the Johns Hopkins Hospital. Using 5-fold cross validation, we demonstrate that our model outperforms three baseline approaches which rely on a classical detection framework. Our model also demonstrates the potential to localize seizure onset zones in focal epilepsy.Comment: To appear in MICCAI 2018 Proceeding

Observation of Anomalous Internal Pair Creation in 8^8Be: A Possible Signature of a Light, Neutral Boson

Electron-positron angular correlations were measured for the isovector magnetic dipole 17.6 MeV state ($J^\pi=1^+$, $T=1$) $\rightarrow$ ground state ($J^\pi=0^+$, $T=0$) and the isoscalar magnetic dipole 18.15 MeV ($J^\pi=1^+$, $T=0$) state $\rightarrow$ ground state transitions in $^{8}$Be. Significant deviation from the internal pair creation was observed at large angles in the angular correlation for the isoscalar transition with a confidence level of $> 5\sigma$. This observation might indicate that, in an intermediate step, a neutral isoscalar particle with a mass of 16.70$\pm0.35$ (stat)$\pm 0.5$ (sys) MeV$/c^2$ and $J^\pi = 1^+$ was created.Comment: 5 pages, 5 figure

Multiple-clause constituent questions: intonation and variation in Hungarian

When a question phrase bears a grammatical function in a subordinate clause but the interrogativity it introduces extends over a higher clause, there are two main possibilities in Hungarian: (i) the question phrase appears preverbally in the clause over which it takes scope, or (ii) the question phrase appears in the subordinate clause while the scope of interrogativity is indicated by the presence of another question phrase in the higher clause (the scope-marking construction). In order to understand the features shared by these two types of question and the ways in which they differ, this article explores the intonation of these types of multiple-clause constituent questions in Hungarian. The results of experimental investigation are reported and discussed, and the significance of these findings is evaluated in the context of wider typological variation in the formation of multiple-clause constituent questions

Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands

Three complexes of general formula PtCl2R2 were synthesized, where R is the amine ligand with aromatic substituents. Coordination compounds [Pt(an)2Cl2] (1), [Pt(pa)2Cl2] (2) and [Pt(aph)2Cl2] (3), where an = 2-aminonaphthalene, pa = 2-aminopyrimidine, aph = 4-anilinophenol, were characterized by on-line coupled TG/DTA-MS, powder XRD and spectroscopic techniques (FTIR, ESI–MS and NMR), and tested against selected Gram(+) and Gram(–) bacteria. The thermal data show that all three compounds contain lattice or absorbed water, and the stability of the anhydrous compounds in nitrogen decreases in the order 2 > 1 > 3. Above 200 °C, the complexes loose characteristic fragments of their ligands. The spectroscopic data are in accordance with the thermal properties of the samples and prove their composition. The compounds are more effective inhibitors of Gram(+) than Gram(−) bacteria. © 2016 Akadémiai Kiadó, Budapest, Hungar

Characterization and Performance of PADME's Cherenkov-Based Small-Angle Calorimeter

The PADME experiment, at the Laboratori Nazionali di Frascati (LNF), in Italy, will search for invisible decays of the hypothetical dark photon via the process $e^+e^-\rightarrow \gamma A'$, where the $A'$ escapes detection. The dark photon mass range sensitivity in a first phase will be 1 to 24 MeV. We report here on measurement and simulation studies of the performance of the Small-Angle Calorimeter, a component of PADME's detector dedicated to rejecting 2- and 3-gamma backgrounds. The crucial requirement is a timing resolution of less than 200 ps, which is satisfied by the choice of PbF$_2$ crystals and the newly released Hamamatsu R13478UV photomultiplier tubes (PMTs). We find a timing resolution of 81 ps (with double-peak separation resolution of 1.8 ns) and a single-crystal energy resolution of 5.7%/$\sqrt{E}$ with light yield of 2.07 photo-electrons per MeV, using 100 to 400 MeV electrons at the Beam Test Facility of LNF. We also propose the investigation of a two-PMT solution coupled to a single PbF$_2$ crystal for higher-energy applications, which has potentially attractive features.Comment: 12 pages, 19 figures. v2: added section on radiation damage studie

Proton decay from the isoscalar giant dipole resonance in 58^{58}Ni

Proton decay from the 3$\hbar\omega$ isoscalar giant dipole resonance (ISGDR) in $^{58}$Ni has been measured using the ($\alpha,\alpha'p$) reaction at a bombarding energy of 386 MeV to investigate its decay properties. We have extracted the ISGDR strength under the coincidence condition between inelastically scattered $\alpha$ particles at forward angles and decay protons emitted at backward angles. Branching ratios for proton decay to low-lying states of $^{57}$Co have been determined, and the results compared to predictions of recent continuum-RPA calculations. The final-state spectra of protons decaying to the low-lying states in $^{57}$Co were analyzed for a more detailed understanding of the structure of the ISGDR. It is found that there are differences in the structure of the ISGDR as a function of excitation energy.Comment: Minor changes after review. Accepted for publication in Phys. Rev. C. 19 pages; 7 figure

Systematic investigation of the elastic proton-deuteron differential cross sectionat intermediate energies

To investigate the importance of three-nucleon forces (3NF) systematically over a broad range of intermediate energies, the differential cross sections of elastic proton-deuteron scattering have been measured at proton bombarding energies of 108, 120, 135, 150, 170, and 190 MeV at c.m. angles between 30° and 170° . Comparisons with Faddeev calculations show unambiguously the shortcomings of calculations employing only two-body forces and the necessity of including 3NF. They also show the limitations of the latest few-nucleon calculations at backward angles, especially at higher beam energies. Some of these discrepancies could be partially due to relativistic effects. Data at lowest energy are also compared with a recent calculation based on χPT .journal articl

Alpha-decay branching ratios of near-threshold states in 19Ne and the astrophysical rate of 15O(alpha,gamma)19Ne

The 15O(alpha,gamma)19Ne reaction is one of two routes for breakout from the hot CNO cycles into the rp process in accreting neutron stars. Its astrophysical rate depends critically on the decay properties of excited states in 19Ne lying just above the 15O + alpha threshold. We have measured the alpha-decay branching ratios for these states using the p(21Ne,t)19Ne reaction at 43 MeV/u. Combining our measurements with previous determinations of the radiative widths of these states, we conclude that no significant breakout from the hot CNO cycle into the rp process in novae is possible via 15O(alpha,gamma)19Ne, assuming current models accurately represent their temperature and density conditions

Terrestrial planet finder interferometer: 2006-2007 progress and plans

This paper provides an overview of technology development for the Terrestrial Planet Finder Interferometer (TPF-I). TPF-I is a mid-infrared space interferometer being designed with the capability of detecting Earth-like planets in the habitable zones around nearby stars. The overall technology roadmap is presented and progress with each of the testbeds is summarized. The current interferometer architecture, design trades, and the viability of possible reduced-scope mission concepts are also presented

Systematic investigation of three-nucleon force effects in elastic scattering of polarized protons from deuterons at intermediate energies

The question, whether the high-quality nucleon-nucleon potentials can successfully describe the three-nucleon system, and to what extent three-nucleon forces (3NFs) play a role, has become very important in nuclear few-body physics. One kinematic region where effects because of 3NFs show up is in the minimum of the differential cross section of elastic nucleon-deuteron scattering. Another observable, which could give an indication about the contribution of the spin to 3NFs, is the vector analyzing power. To investigate the importance of 3NFs systematically over a broad range of intermediate energies, both observables of elastic proton-deuteron scattering have been measured at proton bombarding energies of 108, 120, 135, 150, 170, and 190 MeV, covering an angular range in the center-of-mass system between 30° and 170°. The results show unambiguously the shortcomings of calculations employing only two-body forces and the necessity of the inclusion of 3NFs. They also show the limitations of the results of the present day models for few-nucleon systems at backward angles, especially at higher beam energies. New calculations based on chiral perturbation theory are also presented and compared with the data at the lowest energy