The Dwarf Galaxy Population of the Dorado group down to Mv=-11

We present V and I CCD photometry of suspected low-surface brightness dwarf galaxies detected in a survey covering ~2.4 deg^2 around the central region of the Dorado group of galaxies. The low-surface brightness galaxies were chosen based on their sizes and magnitudes at the limiting isophote of 26.0V\mu. The selected galaxies have magnitudes brighter than V=20 (Mv=-11 for an assumed distance to the group of 17.2 Mpc), with central surface brightnesses \mu0>22.5 V mag/arcsec^2, scale lengths h>2'', and diameters > 14'' at the limiting isophote. Using these criteria, we identified 69 dwarf galaxy candidates. Four of them are large very low-surface brightness galaxies that were detected on a smoothed image, after masking high surface brightness objects. Monte Carlo simulations performed to estimate completeness, photometric uncertainties and to evaluate our ability to detect extended low-surface brightness galaxies show that the completeness fraction is, on average, > 80% for dwarf galaxies with $-17<M_{V}<-10.5$ and 22.5<\mu0<25.5 V mag/arcsec^2, for the range of sizes considered by us (D>14''). The V-I colors of the dwarf candidates vary from -0.3 to 2.3 with a peak on V-I=0.98, suggesting a range of different stellar populations in these galaxies. The projected surface density of the dwarf galaxies shows a concentration towards the group center similar in extent to that found around five X-ray groups and the elliptical galaxy NGC1132 studied by Mulchaey and Zabludoff (1999), suggesting that the dwarf galaxies in Dorado are probably physically associated with the overall potential well of the group.Comment: 32 pages, 16 postscript figures and 3 figures in GIF format, aastex v5.0. To appear in The Astronomical Journal, January 200

RCS043938-2904.9: A New Rich Cluster of Galaxies at z=0.951

We present deep I, J_s, K_s imaging and optical spectroscopy of the newly discovered Red-Sequence Cluster Survey cluster RCS043938-2904.9. This cluster, drawn from an extensive preliminary list, was selected for detailed study on the basis of its apparent optical richness. Spectroscopy of 11 members places the cluster at z=0.951 +- 0.006, and confirms the photometric redshift estimate from the (R-z) color-magnitude diagram. Analysis of the infrared imaging data demonstrates that the cluster is extremely rich, with excess counts in the Ks-band exceeding the expected background counts by 9 sigma. The properties of the galaxies in RCS043938-2904.9 are consistent with those seen in other clusters at similar redshifts. Specifically, the red-sequence color, slope and scatter, and the size-magnitude relation of these galaxies are all consistent with that seen in the few other high redshift clusters known, and indeed are consistent with appropriately evolved properties of local cluster galaxies. The apparent consistency of these systems implies that the rich, high-redshift RCS clusters are directly comparable to the few other systems known at z ~ 1, most of which have been selected on the basis of X-ray emission.Comment: 12 pages, 1 color figure. Accepted for publication on The ApJ Letter

Amyloid beta and diabetic pathology cooperatively stimulate cytokine expression in an Alzheimer's mouse model

Background Diabetes is a risk factor for developing Alzheimer's disease (AD); however, the mechanism by which diabetes can promote AD pathology remains unknown. Diabetes results in diverse molecular changes in the brain, including dysregulation of glucose metabolism and loss of cerebrovascular homeostasis. Although these changes have been associated with increased A beta pathology and increased expression of glial activation markers in APPswe/PS1dE9 (APP/PS1) mice, there has been limited characterization, to date, of the neuroinflammatory changes associated with diabetic conditions. Methods To more fully elucidate neuroinflammatory changes associated with diabetes that may drive AD pathology, we combined the APP/PS1 mouse model with either high-fat diet (HFD, a model of pre-diabetes), the genetic db/db model of type 2 diabetes, or the streptozotocin (STZ) model of type 1 diabetes. We then used a multiplexed immunoassay to quantify cortical changes in cytokine proteins. Results Our analysis revealed that pathology associated with either db/db, HFD, or STZ models yielded upregulation of a broad profile of cytokines, including chemokines (e.g., MIP-1 alpha, MIP-1 beta, and MCP-1) and pro-inflammatory cytokines, including IL-1 alpha, IFN-gamma, and IL-3. Moreover, multivariate partial least squares regression analysis showed that combined diabetic-APP/PS1 models yielded cooperatively enhanced expression of the cytokine profile associated with each diabetic model alone. Finally, in APP/PS1xdb/db mice, we found that circulating levels of A beta 1-40, A beta 1-42, glucose, and insulin all correlated with cytokine expression in the brain, suggesting a strong relationship between peripheral changes and brain pathology. Conclusions Altogether, our multiplexed analysis of cytokines shows that Alzheimer's and diabetic pathologies cooperate to enhance profiles of cytokines reported to be involved in both diseases. Moreover, since many of the identified cytokines promote neuronal injury, A beta and tau pathology, and breakdown of the blood-brain barrier, our data suggest that neuroinflammation may mediate the effects of diabetes on AD pathogenesis. Therefore, strategies targeting neuroinflammatory signaling, as well as metabolic control, may provide a promising strategy for intervening in the development of diabetes-associated AD

Quasars Clustering at z approx 3 on Scales less sim 10 h^{-1} Mpc

We test the hypothesis whether high redshift QSOs would preferentially appear in small groups or pairs, and if they are associated with massive, young clusters. We carried out a photometric search for \Ly emitters on scales $\lesssim 10 h^{-1}$ Mpc, in the fields of a sample of 47 $z\approx3$ known QSOs. Wide and narrow band filter color-magnitude diagrams were generated for each of the $6'.6\times6'.6$ fields. A total of 13 non resolved objects with a significant color excess were detected as QSO candidates at a redshift similar to that of the target. All the candidates are significantly fainter than the reference QSOs, with only 2 of them within 2 magnitudes of the central object. Follow-up spectroscopic observations have shown that 5, i.e., about 40% of the candidates, are QSOs at the same redshift of the target; 4 are QSOs at different z (two of them probably being a lensed pair at z = 1.47); 2 candidates are unresolved HII galaxies at z$\sim$0.3; one unclassified and one candidate turned out to be a CCD flaw. These data indicate that at least 10% of the QSOs at z$\sim$3 do have companions. We have also detected a number of resolved, rather bright \Ly Emitter Candidates. Most probably a large fraction of them might be bright galaxies with [OII] emission, at z$\approx$ 0.3. The fainter population of our candidates corresponds to the current expectations. Thus, there are no strong indication for the existence of an overdensity of \Ly galaxies brighter than m $\approx$ 25 around QSOs at $z\approx$ 3.Comment: 29 pages, 8 figures, tar gzip LaTex file, accepted to appear in Ap

Spin and lattice excitations of a BiFeO3 thin film and ceramics

We present a comprehensive study of polar and magnetic excitations in BiFeO3 ceramics and a thin film epitaxially grown on an orthorhombic (110) TbScO3 substrate. Infrared reflectivity spectroscopy was performed at temperatures from 5 to 900 K for the ceramics and below room temperature for the thin film. All 13 polar phonons allowed by the factor-group analysis were observed in theceramic samples. The thin-film spectra revealed 12 phonon modes only and an additional weak excitation, probably of spin origin. On heating towards the ferroelectric phase transition near 1100 K, some phonons soften, leading to an increase in the static permittivity. In the ceramics, terahertz transmission spectra show five low-energy magnetic excitations including two which were not previously known to be infrared active; at 5 K, their frequencies are 53 and 56 cm-1. Heating induces softening of all magnetic modes. At a temperature of 5 K, applying an external magnetic field of up to 7 T irreversibly alters the intensities of some of these modes. The frequencies of the observed spin excitations provide support for the recently developed complex model of magnetic interactions in BiFeO3 (R.S. Fishman, Phys. Rev. B 87, 224419 (2013)). The simultaneous infrared and Raman activity of the spin excitations is consistent with their assignment to electromagnons

Utilidade da PET/CT, (18F-FDG), no estudo do linfoma Hodgkin e linfoma não Hodgkin

Os linfomas são tumores estabelecidos a nível do sistema linfático. Devido à sua heterogeneidade classificam-se como Linfoma Hodgkin (LH) e Linfoma não Hodgkin (LNH), apresentando diferente prognóstico e seguimento quimioterapêutico. Actualmente, a Photon Emission Tomography/Computed Tomography (PET/CT, do acrónimo inglês) é considerada “imagem” de excelência no estudo desta patologia. Neste contexto, é objectivo deste artigo verificar a utilidade da técnica PET/CT e correlacionar o valor de Standard Uptake Value (SUV), obtido pela PET, com o estadio histológico do linfoma e com a resposta ao tratamento quimioterapêutico. Metodologia - Analisaram-se retrospectivamente 356 estudos respeitantes a 231 pacientes, aos quais se realizou uma PET/CT para estadiamento, estudo de massa ou avaliação da resposta ao tratamento. Após a administração de uma actividade média de 18F-FDG de 288,6 MBq, foram adquiridas imagens numa PET/CT GE Discovery ST. Os resultados obtidos foram comparados com os dados clínicos dos pacientes. Resultados - Foram encontradas diferenças significativas entre a idade Vs tipo de linfoma. Não foram encontradas diferenças significativas entre: valor de SUVmáx ganglionar, lesões extra-ganglionares e seu valor de SUV relativamente ao tipo de linfoma. Comprovou-se a influência da PET/CT na alteração do estadio do linfoma e atitude terapêutica. Em última análise, obtiveram-se respectivamente os seguintes valores de sensibilidade, especificidade e exactidão: 98%, 79% e 88%. Conclusões - Os resultados obtidos permitem verificar a importância da imagem PET/CT no estadiamento, monitorização e alteração da atitude terapêutica dos LH e LNH

ACS Observations of a Strongly Lensed Arc in a Field Elliptical

We report the discovery of a strongly lensed arc system around a field elliptical galaxy in Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS) images of a parallel field observed during NICMOS observations of the HST Ultra-Deep Field. The ACS parallel data comprise deep imaging in the F435W, F606W, F775W, and F850LP bandpasses. The main arc is at a radius of 1.6 arcsec from the galaxy center and subtends about 120 deg. Spectroscopic follow-up at Magellan Observatory yields a redshift z=0.6174 for the lensing galaxy, and we photometrically estimate z_phot = 2.4\pm0.3 for the arc. We also identify a likely counter-arc at a radius of 0.6 arcsec, which shows structure similar to that seen in the main arc. We model this system and find a good fit to an elliptical isothermal potential of velocity dispersion $\sigma \approx 300$ \kms, the value expected from the fundamental plane, and some external shear. Several other galaxies in the field have colors similar to the lensing galaxy and likely make up a small group.Comment: Accepted for publication in ApJ Letters. 10 pages, 3 figures. Figures have been degraded to meet size limit; a higher resolution version and addtional pictures available at http://acs.pha.jhu.edu/~jpb/UDFparc

Determination of picloram in waters by sequential injection chromatography with UV detection

This paper describes a sequential injection chromatography procedure for determination of picloram in waters exploring the low backpressure of a 2.5 cm long monolithic C18 column. Separation of the analyte from the matrix was achieved in less than 60 s using a mobile phase composed by 20:80 (v v-1) acetonitrile:5.0 mmol L-1 H3PO4 and flow rate of 30 &#956;L s-1. Detection was made at 223 nm with a 40 mm optical path length cell. The limits of detection and quantification were 33 and 137 &#956;g L-1, respectively. The proposed method is sensitive enough to monitor the maximum concentration level for picloram in drinking water (500 &#956;g L-1). The sampling frequency is 60 analyses per hour, consuming only 300 &#956;L of acetonitrile per analysis. The proposed methodology was applied to spiked river water samples and no statistically significant differences were observed in comparison to a conventional HPLC-UV method.Este trabalho descreve um procedimento de cromatografia por injeção seqüencial para a determinação de picloram em águas explorando a baixa pressão de uma coluna monolítica C18 de 2,5 cm de comprimento. A separação do analito da matriz foi obtida em menos de 60 s usando como fase móvel uma mistura de acetonitrila e H3PO4 5,0 mmol L-1 na proporção 20:80 (v v-1) e vazão de 30 &#956;L s-1. Detecção foi feita a 223 nm com uma cela de 40 mm de caminho óptico. O limite de detecção do método é adequado para monitorar o nível de concentração máximo permitido para picloram em água potável (500 &#956;g L-1). A frequência de amostragem é de 60 análises por hora, consumindo 300 &#956;L de acetonitrila por análise. A metodologia foi aplicada a águas de rio fortificadas, não sendo observadas diferenças estatisticamente significativas em comparação com a metodologia convencional de HPLC-UV.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

The Primordial Gravitational Wave Background in String Cosmology

We find the spectrum P(w)dw of the gravitational wave background produced in the early universe in string theory. We work in the framework of String Driven Cosmology, whose scale factors are computed with the low-energy effective string equations as well as selfconsistent solutions of General Relativity with a gas of strings as source. The scale factor evolution is described by an early string driven inflationary stage with an instantaneous transition to a radiation dominated stage and successive matter dominated stage. This is an expanding string cosmology always running on positive proper cosmic time. A careful treatment of the scale factor evolution and involved transitions is made. A full prediction on the power spectrum of gravitational waves without any free-parameters is given. We study and show explicitly the effect of the dilaton field, characteristic to this kind of cosmologies. We compute the spectrum for the same evolution description with three differents approachs. Some features of gravitational wave spectra, as peaks and asymptotic behaviours, are found direct consequences of the dilaton involved and not only of the scale factor evolution. A comparative analysis of different treatments, solutions and compatibility with observational bounds or detection perspectives is made.Comment: LaTeX, 50 pages with 2 figures. Uses epsfig and psfra