Local fractional system for economic order quantity using entropy solution

Abstract The economic order quantity (EOQ) model describes the quantity that minimizes the aggregate sum of all cost functions. We propose an assembly for EOQ, nonlinear local fractional differential models with costs functions with respect to time in a cyclic period. For this system, using fractional entropy, we study the related optimization problem and improve a relaxed method for calculating a bounded interval containing the optimal cycle length. Also, for a special class of transportation functions, we study these consequences and introduce processes to compute the optimal size and the matching optimal order stage

1,8-Substituted anthraquinones, anthrones and bianthrones as potential non-azole leads against fungal infections

The synthesis of a variety of 1,8-substituted anthraquinones, anthrones and bianthrones and their potential as antifungal agents is evaluated. Preliminary screening against Schizosaccharomyces pombe (S. pombe), a fission yeast, and Saccharomyces cerevisiae (S. cerevisiae), a budding yeast, is reported. Both these yeast species demonstrate close homologue to a number of pathogenic fungi. [Abstract copyright: Copyright © 2019. Published by Elsevier Inc.

N-Alkylated Linear Heptamethine Polyenes as Potent Non-Azole Leads against Candida Albicans Fungal Infections

In this study, eighteen heptamethine dyes were synthesised and their antifungal activities were evaluated against three clinically relevant yeast species.. The eighteen dyes were placed within classes based on their core subunit i.e. 2,3,3-trimethylindolenine (5a-f), 1,1,2-trimethyl-1H-benzo[e]indole (6a-f), or 2-methylbenzothiazole (7a-f). The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections. This opens up the opportunity for further optimisation and investigation of this class compounds for potential antifungal treatment