Aerodynamic Analysis Of Voice In Persons With Laryngopharyngeal Reflux

Objectives of the study: The individuals with laryngopharyngeal reflux are prone for aspiration of refluxed contents and so there is a need for aerodynamic evaluation in these individuals. Hence, the present study investigated the aerodynamic characteristics in individuals with Laryngopharyngeal reflux. Study design: Prospective control group design. Method: Thirty laryngopharyngeal reflux subjects and 30 normal subjects participated in the study. Aerodynamic parameters such as vital capacity, mean air flow rate, maximum phonation duration and phonation quotient were measured using Aero Phone Instrument ((Model 6800). Independent t test was employed for statistical inference. Results: The results revealed that the vital capacity and maximum phonation duration values were lower for laryngopharyngeal reflux subjects when compared to normal controls. No significant differences were observed for mean air flow rate and phonation quotient. Conclusions: The results revealed that the laryngopharyngeal reflux individuals showed significant deviations in aerodynamic parameters when compared to normal individuals. Thus study confirms aerodynamic abnormalities in laryngopharyngeal reflux subject

The Influence of High-Energy Lithium Ion Irradiation on Electrical Characteristics of Silicon and GaAs Solar Cells

Space-grade Si and GaAs solar cells were irradiated with 15 & 40 MeV Li ions. Illuminated (AM0 condition) and unilluminated I-V curves reveal that the effect of high-energy Li ion irradiation has produced similar effects to that of proton irradiation. However, an additional, and different, defect mechanism is suggested to dominate in the heavier-ion results. Comparison is made with proton-irradiated solar-cell work and with non-ionizing energy-loss (NIEL) radiation-damage models.Comment: 8 pages, 12 figures, Data presented at 2006 NSREC, Final Version to be published in IEEE Transactions on Nuclear Science, 53, NO. 6, December 2006. Index Terms: GaAs, Ion-irradiation, Lithium, NIEL, Photovoltaic cells, Radiation effects, Silico

Agricultural growth linkages in Sub-Saharan Africa:

How much extra net income growth can be had in rural areas of Africa by increasing the spending power of local households? The answer depends on how rural households spend increments to income, whether the items desired can be imported to the local area in response to increased demand, and, if not, whether increased demand will lead to new local production or simply to price rises. For every dollar in new farm income earned, at least one additional dollar could be realized from growth multipliers, according to Agricultural Growth Linkages in Sub-Saharan Africa.Income Rural areas Africa., Agricultural development Africa., Agricultural policy Economic aspects., Households Zimbabwe., Social accounting., Africa sub-Saharan,

Nanostructured Cubosomes in a Thermoresponsive Depot System: An Alternative Approach for the Controlled Delivery of Docetaxel

The aim of the present study was to develop and evaluate a thermoresponsive depot system comprising of docetaxel-loaded cubosomes. The cubosomes were dispersed within a thermoreversible gelling system for controlled drug delivery. The cubosome dispersion was prepared by dilution method, followed by homogenization using glyceryl monooleate, ethanol and Pluronic® F127 in distilled water. The cubosome dispersion was then incorporated into a gelling system prepared with Pluronic®F127 and Pluronic® F68 in various ratios to formulate a thermoresponsive depot system. The thermoresponsive depot formulations undergo a thermoreversible gelation process i.e., they exists as free flowing liquids at room temperature, and transforms into gels at higher temperatures e.g., body temperature, to form a stable depot in aqueous environment. The mean particle size of the cubosomes in the dispersion prepared with Pluronic® F127, with and without the drug was found to be 170 and 280 nm, respectively. The prepared thermoresponsive depot system was evaluated by assessing various parameters like time for gelation, injectability, gel erosion, and in-vitro drug release. The drug-release studies of the cubosome dispersion before incorporation into the gelling system revealed that a majority (∼97%) of the drug was released within 12 h. This formulation also showed a short lag time (∼3 min). However, when incorpo- rated into a thermoresponsive depot system, the formulation exhibited an initial burst release of∼21%, and released only∼ 39% drug over a period of 12 h, thus indicating its potential as a controlled drug delivery system

In vitro and in vivo anticancer studies of 2'-hydroxy chalcone derivatives exhibit apoptosis in colon cancer cells by HDAC inhibition and cell cycle arrest

Considering the therapeutic values of bioflavonoids in colon cancer treatment, six 2′-hydroxy chalcones (C1-C6) were synthesized, characterized and screened for in vitro cytotoxicity on human colon carcinoma (HCT116) and African green monkey kidney epithelial cells (Vero). Only C5 showed selective cytotoxicity against HCT116 cells. Other potent cytotoxic compounds were C1, C2 and C3. Further screening included enzyme inhibition studies on histone deacetylase (HDAC) enzyme where C1 showed lowest IC50 value (105.03 µM). Based on cytotoxicity data C1, C2 and C3 were selected for further in vitro mechanistic studies, namely apoptotic studies (Acridine or- ange/Ethidium bromide (AO/EB) and Annexin V), cell cycle analysis using propidium iodide (PI) stain and in vivo anticancer efficacy in 1,2-dimethyl hydrazine (DMH) induced colorectal carcinoma in Wistar rats. The com- pounds induced apoptosis in more than 30 % cells in AO/EB and Annexin V staining. They also showed cell cycle arrest in G2/M phase with PI staining. They showed a significant reduction in aberrant crypt foci formation and adenocarcinoma count along with a significant (p<0.05) reduction in TNF-α levels as compared to DMH control at 100 mg/kg dose. Thus, it can be concluded that the synthesized 2′-hydroxychalcones were effective against colon adenocarcinoma in in vitro and in vivo studies

Antidiabetic activity of 3-hydroxyflavone analogues in high fructose fed insulin resistant rats

Synthetic 3-hydroxyflavone analogues (JY-1, JY-2, JY-3, JY-4), were tested for antidiabetic activity in high-fructose-diet-fed (66 %, for 6 weeks) insulin-resistant Wistar rats (FD-fed rats). The fasting blood glucose, insulin, creatinine and AGEs were decreased to near normal upon treatment with test compounds. Insulin resistance markers such as HOMA-IR, K-ITT, plasma triglycerides, lipids, endogenous antioxidant defense and glycogen were restored in FD-fed rats after treatment with 3-hydroxyflavones. It is known that insulin resistance is partly because of oxidative stress and hence antioxidant activity was determined. They exhibited significant in vitro DPPH and ABTS radical scavenging activity (IC50: 10.66-66.63 μM). Test compounds inhibited ROS and NO production in RAW 264.7 cells (IC50: 10.39–42.63 μM) and they were found as potent as quercetin. Further, the test compounds inhibited lipid peroxidation at low concentrations (IC50: 99.61-217.47 μM). All test compounds at concentrations 100-200 μM protected calf thymus DNA-damage by Fenton reaction. In addition, test compounds inhibited protein glycation in different in vitro antiglycation assays. JY-2 showed maximum potency in all the stages of glycation which was comparable to the standard quercetin and aminoguanidine. Test compounds also enhanced the glucose uptake by L6 myotubes at an EC50 much lower than that of quercetin. Thus the synthetic 3-hydroxyflavones were found to have good antidiabetic activity by pleotropic and multimodal suppression of insulin resistance and enhancement of glucose uptake by skeletal muscles. These compounds are non-toxic at the doses tested. Further, the combined antioxidant and antiglycation activities of these molecules have complementary benefits in management of diabetes

Studies of Quasi Periodic Oscillations in the Black Hole Transient XTE J 1817-330

We have used archival RXTE PCA data to investigate timing and spectral characteristics of the transient XTE J1817-330. The data pertains to 160 PCA pointed observations made during the outburst period 2006, January 27 to August 2. A detailed analysis of Quasi-Periodic Oscillations (QPOs) in this black hole X-ray binary is carried out. Power density spectra were obtained using the light curves of the source. QPOs have been detected in the 2-8 keV band in 10 of the observations. In 8 of these observations, QPOs are present in the 8-14 keV and in 5 observations in the 15-25 keV band. XTE J1817-330 is the third black hole source from which the low frequency QPOs are clearly detected in hard X-rays. The QPO frequency lies in ~ 4-9 Hz and the rms amplitude in 1.7-13.3% range, the amplitude being higher at higher energies. We have fitted the PDS of the observations with Lorentzian and power law models. Energy spectra are derived for those observations in which the QPOs are detected to investigate any dependence of the QPO characteristic on the spectral parameters. These spectra are well fitted with a two component model that includes the disk black body component and a power law component. The QPO characteristics and their variations are discussed and its implication on the origin of the QPOs are examinedComment: 16 page, 9 figures and 2 tables. Accepted in MNRAS Journa

Effect of an extract of Centella asiatica on the biodistribution of sodium pertechnetate (Na^99mTcO₄) and on the fixation of radioactivity on blood constituents

This study evaluates the effects of an acute treatment with a Centella asiatica (CA) extract on the biodistribution of the radiopharmaceutical Na99mTcO4 and on the fixation of technetium-99m on blood constituents. Wistar rats were treated with CA extract and, 1 hour after, Na99mTcO4 was administered; organs/tissues were withdrawn and weighted. The radioactivity was counted to calculate the percentage of activity per gram (%ATI/g). Also, blood samples were withdrawn, plasma (P), blood cells (BC), insoluble fraction (IF) and soluble fractions of P and BC were isolated and the radioactivity was counted to calculate the percentage of activity (%ATI). Data indicated that the acute treatment with CA extract changed significantly (p99mTcO4 and the fixation of the technetium-99m on blood constituents in an acute treatment

Conservation of millets: the role of community leaders in Kolli Hills, South India

101-110Traditional knowledge is based on vast experiences gained over centuries that is communicated from one generation to another. With growing concerns of malnutrition and dietary diversity, traditional food and cultivation practices are gaining attention of scientific and development communities. Efforts to extract this knowledge apart, there is also a need to understand how this has been transmitted. A shift from focus on knowledge to focus on practice may provide pathways to understand how communities adopt and sustain certain practices over generations. This study is on the role of community influencers – known as ‘Oor Goundars’ (village leaders) among the tribal communities of Kolli Hills in Tamil Nadu, South India – in conserving millet landraces. Using the Social Practice Theory, the existing role and importance of these community leaders is analyzed. The study finds that conservation of rich knowledge of social, cultural and agricultural practices reposed with traditional community influencers such as Oor Goundars is diminishing. It probes whether it may be possible to preserve or enhance traditional knowledge within its setting by increasing focus and attention on these influencers and the cultural practices that they impact

Conservation of millets: the role of community leaders in Kolli Hills, South India

Traditional knowledge is based on vast experiences gained over centuries that is communicated from one generation to another. With growing concerns of malnutrition and dietary diversity, traditional food and cultivation practices are gaining attention of scientific and development communities. Efforts to extract this knowledge apart, there is also a need to understand how this has been transmitted. A shift from focus on knowledge to focus on practice may provide pathways to understand how communities adopt and sustain certain practices over generations. This study is on the role of community influencers – known as ‘Oor Goundars’ (village leaders) among the tribal communities of Kolli Hills in Tamil Nadu, South India – in conserving millet landraces. Using the Social Practice Theory, the existing role and importance of these community leaders is analyzed. The study finds that conservation of rich knowledge of social, cultural and agricultural practices reposed with traditional community influencers such as Oor Goundars is diminishing. It probes whether it may be possible to preserve or enhance traditional knowledge within its setting by increasing focus and attention on these influencers and the cultural practices that they impact