Biomedical Informatics Applications for Precision Management of Neurodegenerative Diseases

Modern medicine is in the midst of a revolution driven by “big data,” rapidly advancing computing power, and broader integration of technology into healthcare. Highly detailed and individualized profiles of both health and disease states are now possible, including biomarkers, genomic profiles, cognitive and behavioral phenotypes, high-frequency assessments, and medical imaging. Although these data are incredibly complex, they can potentially be used to understand multi-determinant causal relationships, elucidate modifiable factors, and ultimately customize treatments based on individual parameters. Especially for neurodegenerative diseases, where an effective therapeutic agent has yet to be discovered, there remains a critical need for an interdisciplinary perspective on data and information management due to the number of unanswered questions. Biomedical informatics is a multidisciplinary field that falls at the intersection of information technology, computer and data science, engineering, and healthcare that will be instrumental for uncovering novel insights into neurodegenerative disease research, including both causal relationships and therapeutic targets and maximizing the utility of both clinical and research data. The present study aims to provide a brief overview of biomedical informatics and how clinical data applications such as clinical decision support tools can be developed to derive new knowledge from the wealth of available data to advance clinical care and scientific research of neurodegenerative diseases in the era of precision medicine

Progenitors of Supernovae Type Ia and Chemical Enrichment in Hydrodynamical Simulations -I. The Single Degenerate Scenario

The nature of the Type Ia supernovae (SNIa) progenitors remains still uncertain. This is a major issue for galaxy evolution models since both chemical and energetic feedback play a major role in the gas dynamics, star formation and therefore in the overall stellar evolution. The progenitor models for the SNIa available in the literature propose different distributions for regulating the explosion times of these events. These functions are known as the Delay Time Distributions (DTDs). This work is the first one in a series of papers aiming at studying five different DTDs for SNIa. Here, we implement and analyse the Single Degenerate scenario (SD) in galaxies dominated by a rapid quenching of the star formation, displaying the majority of the stars concentrated in the bulge component. We find a good fit to both the present observed SNIa rates in spheroidal dominated galaxies, and to the [O/Fe] ratios shown by the bulge of the Milky Way. Additionally, the SD scenario is found to reproduce a correlation between the specific SNIa rate and the specific star formation rate, which closely resembles the observational trend, at variance with previous works. Our results suggest that SNIa observations in galaxies with very low and very high specific star formation rates can help to impose more stringent constraints on the DTDs and therefore on SNIa progenitors.Comment: 19 pages, 6 figures, 1 table. Accepted for publication in Ap

A prospective observational study of mycophenolate mofetil treatment in progressive diffuse cutaneous systemic sclerosis of recent onset.

OBJECTIVE: A prospective observational study of mycophenolate mofetil (MMF) treatment in patients with diffuse progressive cutaneous systemic sclerosis (SSc) of recent onset. METHODS: Twenty-five previously untreated consecutive patients with recent-onset (\u3c 24 mo) diffuse progressive cutaneous SSc received MMF as the only disease-modifying therapy. Modified Rodnan skin score (mRSS) and affected body surface area (BSA) were compared from initiation of MMF to study end. Pulmonary function tests performed at the same institution before therapy and at study end were available in 15 patients. Histopathology and real-time PCR assessment of fibrosis-related gene expression were performed before and after treatment in skin biopsies from 3 patients. RESULTS: At 18.2 ± 8.73 months of MMF therapy (median 2000 mg/day) the mRSS decreased from 24.56 ± 8.62 to 14.52 ± 10.9 (p = 0.0004) and the affected BSA from 36% ± 16% to 14% ± 13.3% (p = 0.00001). Pulmonary function tests remained stable from initiation of MMF to the end of the study. Skin histopathology showed a remarkable reduction in accumulation of fibrotic tissue. Real-time PCR of skin biopsies demonstrated a marked decrease in expression of fibrosis-related genes. CONCLUSION: Patients with diffuse progressive cutaneous SSc of recent onset treated with MMF experienced marked improvement in skin involvement and stabilization of pulmonary function. Skin biopsies from 3 patients demonstrated histopathological improvement and decreased expression of fibrosis-related genes

Nitrogen Incorporation in CH_4-N_2 Photochemical Aerosol Produced by Far Ultraviolet Irradiation

Nitrile incorporation into Titan aerosol accompanying hydrocarbon chemistry is thought to be driven by extreme UV wavelengths (λ120 nm is presently unaccounted for in atmospheric photochemical models. We suggest that reaction with CH radicals produced from CH_4 photolysis may provide a mechanism for incorporating N into the molecular structure of the aerosol. Further work is needed to understand the chemistry involved, as these processes may have significant implications for how we view prebiotic chemistry on early Earth and similar planets. Key Words: Titan—Photochemical aerosol—CH_4-N_2 photolysis—Far UV—Nitrogen activation

The star-formation histories of elliptical galaxies across the fundamental plane

We present the first results from a study designed to test whether, given high-quality spectrophotometry spanning the mid-UV--optical wavelength regime, it is possible to distinguish the metal content (Z) and star-formation history (sfh) of individual elliptical galaxies with sufficient accuracy to establish whether their formation history is linked to their detailed morphology and position on the Fundamental Plane. From a detailed analysis of UV-optical spectrophotometry of the `cuspy' elliptical galaxy NGC 3605 and the giant elliptical NGC 5018 we find that: 1) optical spectra with l > 3500 A may not contain sufficient data to robustly uncover all the stellar populations present in individual galaxies, even in such relatively passive objects as ellipticals, 2) the addition of the UV data approaching l = 2500 A holds the key to establishing well-constrained sfhs, from which we can infer a formation and evolution history which is consistent with their photometric properties, 3) despite the superficial similarity of their spectra, the two galaxies have very different `recent' sfhs -- the smaller, cuspy elliptical NGC 3605 contains a high-Z population of age ~= 1 Gyr, and has a position on the fundamental plane typical of the product of a low-z gas-rich merger (most likely at z ~ 0.08), while the giant elliptical NGC 5018, with a sub-solar secondary population, appears to have gained its more recent stars via mass transfer / accretion of gas from its spiral companion, 4) despite these differences in detailed history, more than 85% of the stellar mass of both galaxies is associated with an old (9-12 Gyr) stellar population of near-solar Z. This pilot study provides strong motivation for the construction and analysis of high-quality UV-optical spectra for a substantial sample of ellipticals spanning the Fundamental Plane.Comment: 11 pages, 10 figures, submitted to MNRAS, revised versio

Dataset concerning the analytical approximation of the Ae3 temperature.

In this paper we present a new polynomial function for calculating the local phase transformation temperature (Ae3 ) between the austenite+ferrite and the fully austenitic phase fields during heating and cooling of steel:[Formula: see text] The dataset includes the terms of the function and the values for the polynomial coefficients for major alloying elements in steel. A short description of the approximation method used to derive and validate the coefficients has also been included. For discussion and application of this model, please refer to the full length article entitled "The role of aluminium in chemical and phase segregation in a TRIP-assisted dual phase steel" 10.1016/j.actamat.2016.05.046 (Ennis et al., 2016) [1]

Charged-current inclusive neutrino cross sections in the SuperScaling model including quasielastic, pion production and meson-exchange contributions

Charged current inclusive neutrino-nucleus cross sections are evaluated using the superscaling model for quasielastic scattering and its extension to the pion production region. The contribution of two-particle-two-hole vector meson-exchange current excitations is also considered within a fully relativistic model tested against electron scattering data. The results are compared with the inclusive neutrino-nucleus data from the T2K and SciBooNE experiments. For experiments where $\langle E_\nu \rangle \sim 0.8$ GeV, the three mechanisms considered in this work provide good agreement with the data. However, when the neutrino energy is larger, effects from beyond the $\Delta$ also appear to be playing a role. The results show that processes induced by two-body currents play a minor role at the kinematics considered.Comment: 10 pages, 7 figure