Prospects of a mathematical theory of human behavior in complex man-machine systems tasks

A hierarchy of human activities is derived by analyzing automobile driving in general terms. A structural description leads to a block diagram and a time-sharing computer analogy. The range of applicability of existing mathematical models is considered with respect to the hierarchy of human activities in actual complex tasks. Other mathematical tools so far not often applied to man machine systems are also discussed. The mathematical descriptions at least briefly considered here include utility, estimation, control, queueing, and fuzzy set theory as well as artificial intelligence techniques. Some thoughts are given as to how these methods might be integrated and how further work might be pursued

Studies of planning behavior of aircraft pilots in normal, abnormal and emergency situations

A methodology for the study of planning is presented and the results of applying the methodology within two experimental investigations of planning behavior of aircraft pilots in normal, abnormal, and emergency situations are discussed. Beyond showing that the methodology yields consistent results, these experiments also lead to concepts in terms of a dichotomy between event driven and time driven planning, subtle effects of automation on planning, and the relationship of planning to workload and flight performance

The influence of anxiety and stress on the presence of periodontopathogens in subjects with aggressive periodontitis

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Max Jury

From local gigs to Lana Del Ray, the Des Moines native sits down with Revival

A Metric for Rapidly Spinning Black Holes Suitable for Strong-Field Tests of the No-Hair Theorem

According to the no-hair theorem, astrophysical black holes are uniquely characterized by their masses and spins and are described by the Kerr metric. Several parametric deviations from the Kerr metric have been suggested to study observational signatures in both the electromagnetic and gravitational-wave spectra that differ from the expected Kerr signals. Due to the no-hair theorem, however, such spacetimes cannot be regular everywhere outside the event horizons, if they are solutions to the Einstein field equations; they are often characterized by naked singularities or closed time-like loops in the regions of the spacetime that are accessible to an external observer. For observational tests of the no-hair theorem that involve phenomena in the vicinity of the circular photon orbit or the innermost stable circular orbit around a black hole, these pathologies limit the applicability of the metrics only to compact objects that do not spin rapidly. In this paper, we construct a Kerr-like metric which depends on a set of free parameters in addition to its mass and spin and which is regular everywhere outside of the event horizon. We derive expressions for the energy and angular momentum of a particle on a circular equatorial orbit around the black hole and compute the locations of the innermost stable circular orbit and the circular photon orbit. We demonstrate that these orbits change significantly for even moderate deviations from the Kerr metric. The properties of our metric make it an ideally suited spacetime to carry out strong-field tests of the no-hair theorem in the electromagnetic spectrum using the properties of accretion flows around astrophysical black holes of arbitrary spin.Comment: 11 pages, 7 figures, accepted for publication in PR

Non-Linear Effects in Non-Kerr spacetimes

There is a chance that the spacetime around massive compact objects which are expected to be black holes is not described by the Kerr metric, but by a metric which can be considered as a perturbation of the Kerr metric. These non-Kerr spacetimes are also known as bumpy black hole spacetimes. We expect that, if some kind of a bumpy black hole exists, the spacetime around it should possess some features which will make the divergence from a Kerr spacetime detectable. One of the differences is that these non-Kerr spacetimes do not posses all the symmetries needed to make them integrable. We discuss how we can take advantage of this fact by examining EMRIs into the Manko-Novikov spacetime.Comment: 8 pages, 3 Figures; to appear in the proceedings of the conference "Relativity and Gravitation: 100 Years after Einstein in Prague" (2012

Evidence of reduced surface electron-phonon scattering in the conduction band of Bi_{2}Se_{3} by non-equilibrium ARPES

The nature of the Dirac quasiparticles in topological insulators calls for a direct investigation of the electron-phonon scattering at the \emph{surface}. By comparing time-resolved ARPES measurements of the TI Bi_{2}Se_{3} with different probing depths we show that the relaxation dynamics of the electronic temperature of the conduction band is much slower at the surface than in the bulk. This observation suggests that surface phonons are less effective in cooling the electron gas in the conduction band.Comment: 5 pages, 3 figure

Perinatal psychiatric episodes: a population-based study on treatment incidence and prevalence

Perinatal psychiatric episodes comprise various disorders and symptom severity, which are diagnosed and treated in multiple treatment settings. To date, no studies have quantified the incidence and prevalence of perinatal psychiatric episodes treated in primary and secondary care, which we aimed to do in the present study. We designed a descriptive prospective study and included information from Danish population registers to study first-time ever and recurrent psychiatric episodes during the perinatal period, including treatment at psychiatric facilities and general practitioners (GPs). This was done for all women who had records of one or more singleton births from 1998 until 2012. In total, we had information on 822 439 children born to 491 242 unique mothers. Results showed first-time psychiatric episodes treated at inpatient facilities were rare during pregnancy, but increased significantly shortly following childbirth (0.02 vs 0.25 per 1000 births). In comparison, first-time psychiatric episodes treated at outpatient facilities were more common, and showed little variation across pregnancy and postpartum. For every single birth resulting in postpartum episodes treated at inpatient psychiatric facilities, 2.5 births were followed by an episode treated at outpatient psychiatric facility and 12 births by GP-provided pharmacological treatment. We interpret our results the following way: treated severe and moderate psychiatric disorders have different risk patterns in relation to pregnancy and childbirth, which suggests differences in the underlying etiology. We further speculate varying treatment incidence and prevalence in pregnancy vs postpartum may indicate that the current Diagnostic and Statistical Manual of Mental Disorders-5 peripartum specifier not adequately describes at-risk periods across moderate and severe perinatal psychiatric episodes

Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs cellular reprogramming

Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes deregulated by specific combinations of these EBNAs through unknown mechanisms. Comparing human genome binding by these viral transcription factors, we discovered that 25% of binding sites were shared by EBNA 2 and the EBNA 3s and were located predominantly in enhancers. Moreover, 80% of potential EBNA 3A, 3B or 3C target genes were also targeted by EBNA 2, implicating extensive interplay between EBNA 2 and 3 proteins in cellular reprogramming. Investigating shared enhancer sites neighbouring two new targets (WEE1 and CTBP2) we discovered that EBNA 3 proteins repress transcription by modulating enhancer-promoter loop formation to establish repressive chromatin hubs or prevent assembly of active hubs. Re-ChIP analysis revealed that EBNA 2 and 3 proteins do not bind simultaneously at shared sites but compete for binding thereby modulating enhancer-promoter interactions. At an EBNA 3-only intergenic enhancer site between ADAM28 and ADAMDEC1 EBNA 3C was also able to independently direct epigenetic repression of both genes through enhancer-promoter looping. Significantly, studying shared or unique EBNA 3 binding sites at WEE1, CTBP2, ITGAL (LFA-1 alpha chain), BCL2L11 (Bim) and the ADAMs, we also discovered that different sets of EBNA 3 proteins bind regulatory elements in a gene and cell-type specific manner. Binding profiles correlated with the effects of individual EBNA 3 proteins on the expression of these genes, providing a molecular basis for the targeting of different sets of cellular genes by the EBNA 3s. Our results therefore highlight the influence of the genomic and cellular context in determining the specificity of gene deregulation by EBV and provide a paradigm for host-cell reprogramming through modulation of enhancer-promoter interactions by viral transcription factors