Leveraging Legal Analytics and Spend Data as a Law Firm Self-Governance Tool

This paper discusses the advantages that law firms can get by using legal analytics (big data) to analyze how they do their work for their clients (and how their clients can benefit as well). We discuss the external forces that are reshaping the economics of today’s legal industry; the types of decisions, in determining how best to represent a client in a given matter, that tend to drive up costs; the possible reasons for those decisions; how law firms can use data-analytics tools to examine their own choices; and the benefits that stem from a data-driven analysis of those choices

NASA/industry advanced turboprop technology program

Experimental and analytical effort shows that use of advanced turboprop (propfan) propulsion instead of conventional turbofans in the older narrow-body airline fleet could reduce fuel consumption for this type of aircraft by up to 50 percent. The NASA Advanced Turboprop (ATP) program was formulated to address the key technologies required for these thin, swept-blade propeller concepts. A NASA, industry, and university team was assembled to develop and validate applicable design codes and prove by ground and flight test the viability of these propeller concepts. Some of the history of the ATP project, an overview of some of the issues, and a summary of the technology developed to make advanced propellers viable in the high-subsonic cruise speed application are presented. The ATP program was awarded the prestigious Robert J. Collier Trophy for the greatest achievement in aeronautics and astronautics in America in 1987

Kinesin Light Chains Are Essential for Axonal Transport in Drosophila

Kinesin is a heterotetramer composed of two 115-kD heavy chains and two 58-kD light chains. The microtubule motor activity of kinesin is performed by the heavy chains, but the functions of the light chains are poorly understood. Mutations were generated in the Drosophila gene Kinesin light chain (Klc), and the phenotypic consequences of loss of Klc function were analyzed at the behavioral and cellular levels. Loss of Klc function results in progressive lethargy, crawling defects, and paralysis followed by death at the end of the second larval instar. Klc mutant axons contain large aggregates of membranous organelles in segmental nerve axons. These aggregates, or organelle jams (Hurd, D.D., and W.M. Saxton. 1996. Genetics. 144: 1075-1085), contain synaptic vesicle precursors as well as organelles that may be transported by kinesin, kinesin-like protein 68D, and cytoplasmic dynein, thus providing evidence that the loss of Klc function blocks multiple pathways of axonal transport. The similarity of the Klc and Khc ((Saxton et al. Cell 64:1093-1102; Hurd, D.D., and W.M. Saxton. 1996. Genetics 144: 1075-1085) mutant phenotypes indicates that KLC is essential for kinesin function, perhaps by tethering KHC to intracellular cargos or by activating the kinesin motor

A simulation evaluation of a four-engine jet transport using engine thrust modulation for flightpath control

The use of throttle control laws to provide adequate flying qualities for flight path control in the event of a total loss of conventional flight control surface use was evaluated. The results are based on a simulation evaluation by transport research pilots of a B-720 transport with visual display. Throttle augmentation control laws can provide flight path control capable of landing a transport-type aircraft with up to moderate levels of turbulence. The throttle augmentation mode dramatically improves the pilots' ability to control flight path for the approach and landing flight condition using only throttle modulation. For light turbulence, the average Cooper-Harper pilot rating improved from unacceptable to acceptable (a pilot rating improvement of 4.5) in going from manual to augmented control. The low frequency response characteristics of the engines require a considerably different piloting technique. The various techniques used by the pilot resulted in considerable scatter in data. Many pilots readily adapted to a good piloting technique while some had difficulty. A new viable approach is shown to provide independent means of redundancy of transport aircraft flight path control

Potential Anticancer Compounds. III, Synthesis of Some 8-Substituted Caffeines and Theophyllines

Author Institution: Department of Chemistry, University of Cincinnati, Cincinnati 21, Ohi

Use of chromium picolinate and biotin in the management of type 2 diabetes: an economic analysis

This paper addresses the potential economic benefits of chromium picolinate plus biotin (Diachrome ®) use in people with Type 2 diabetes (T2DM). The economic model was developed to estimate the impact on health care systems’ costs by improved HbA1C levels with chromium picolinate plus biotin (Diachrome). Lifetimes cost savings were estimated by adjusting a benchmark from the literature, using a price index to adjust for inflation. The cost of diabetes is highly dependent on the HbA1C level with higher initial levels and higher annual increments increasing the cost. Improvement in glycemic control has proven to be cost-effective in delaying the onset and progression of T2DM, reducing the risk for diabetes-associated complications and lowering utilization and cost of care. Chromium picolinate plus biotin (Diachrome) showed greater improvement of glycemic control in poorly controlled T2DM patients (HbA1C \u3e=10%) compared to their better controlled counterparts (HbA1C \u3c 10%). This improvement was additive to that achieved by oral hypoglycemic medications and correlates to calculated levels of cost savings. Average 3-year cost savings for chromium picolinate plus biotin (Diachrome) use could range from $1,636 for a poorly controlled patient with diabetes without heart diseases or hypertension, to$5,435 for a poorly controlled patient with diabetes, heart disease, and hypertension. Average 3-year cost savings was estimated to be between $3.9 billion and$52.9 billion for the 16.3 million existing patients with diabetes. Chromium picolinate plus biotin (Diachrome) use among the 1.17 million newly diagnosed patients with T2DM each year could deliver lifetime cost savings of $42 billion, or$36,000 per T2DM patient. Affordable, safe, and convenient, chromium picolinate plus biotin (Diachrome) could prove to be a cost-effective complement to existing pharmacological therapies for controlling T2DM. (Disease Management 2005;8:265–275

Ariel - Volume 4 Number 5

Editors David A. Jacoby Eugenia Miller Tom Williams Associate Editors Paul Bialas Terry Burt Michael Leo Gail Tenikat Editor Emeritus and Business Manager Richard J. Bonnano Movie Editor Robert Breckenridge Staff Richard. Blutstein Mary F. Buechler Alice M. Johnson J.D. Kanofskv Rocky Webe

Supersonic boundary-layer transition on the LaRC F-106 and the DFRF F-15 aircraft. Part 1: Transition measurements and stability analysis

For the case of the F-15 flight tests, boundary layer transition was observed up to Mach numbers of 1.2. For very limited and specific flight conditions, laminar flow existed back to about 20 percent chord on the surface clean up glove. Hot film instrumentation was effective for locating the region of transition. For the F-106 flight tests, transition on the wing or vertical tail generally occurred very near the attachment line. Transition was believed to be caused by either attachment line contamination or strong cross flow development due to the high sweep angles of the test articles. The compressibility analysis showed that cross flow N-factors were in the range of 5 to 12 at transition