The Contact Lens Impact on Quality of Life (CLIQ) questionnaire: development and validation

NoPURPOSE. To develop and validate a questionnaire for the measurement of the impact of contact lenses on quality of life (QoL): The Contact Lens Impact on Quality of Life (CLIQ) Questionnaire. METHODS. The questionnaire was developed and validated using conventional methods and Rasch analysis to assure content validity, repeatability, construct validity, and low respondent burden. Item identification and selection (647 items) were performed with an extensive literature review, professional advice, and lay focus groups. Item reduction used focus groups and data obtained from 161 subjects completing a 90-item pilot questionnaire. Validity and reliability, from data of 128 additional subjects, were assessed using Rasch analysis, intraclass correlation coefficient, and Bland-Altman limits of agreement. RESULTS. A 28-item CLIQ Questionnaire was developed and shown to have good validity and reliability by Rasch analysis statistics: real person separation, 2.02; model person separation, 2.17; reliability, 0.80; root mean square measurement error, 2.73; mean square ± SD infit, 1.01 ± 0.18; outfit, 1.01 ± 0.19. The items (mean score, 49.8 ± 4.9) were well targeted to the subjects (mean score, 51.2 ± 6.2) with a mean difference of 1.35 (scale range, 0-100) units. Test-retest intraclass correlation coefficient (0.86) and coefficient of repeatability (±8.00 units) demonstrated good repeatability. CONCLUSIONS. Rasch analysis and standard psychometric analyses demonstrated that the 28-item CLIQ Questionnaire is a valid and reliable measure of QoL in contact lens wearers. A scoring algorithm is provided for CLIQ Questionnaire users to convert raw scores into the Rasch analysis-derived linear person measures

Melting transitions in biomembranes

We investigated melting transitions in biological membranes in their native state that include their membrane proteins. These membranes originated from \textit{E. coli}, \textit{B. subtilis}, lung surfactant and nerve tissue from the spinal cord of several mammals. For some preparations, we studied the pressure, pH and ionic strength dependence of the transition. For porcine spine, we compared the transition of the native membrane to that of the extracted lipids. All preparations displayed melting transitions of 10-20 degrees below physiological or growth temperature, independent of the organism of origin and the respective cell type. The position of transitions in \textit{E. coli} membranes depends on the growth temperature. We discuss these findings in the context of the thermodynamic theory of membrane fluctuations that leads to largely altered elastic constants, an increase in fluctuation lifetime and in membrane permeability associated with the transitions. We also discuss how to distinguish lipid transitions from protein unfolding transitions. Since the feature of a transition slightly below physiological temperature is conserved even when growth conditions change, we conclude that the transitions are likely to be of major biological importance for the survival and the function of the cell.Comment: 12 pages, 6 Figures, 1 supplement with 1 figur

Production of heralded pure single photons from imperfect sources using cross phase modulation

Realistic single-photon sources do not generate single photons with certainty. Instead they produce statistical mixtures of photons in Fock states $\ket{1}$ and vacuum (noise). We describe how to eliminate the noise in the output of the sources by means of another noisy source or a coherent state and cross phase modulation (XPM). We present a scheme which announces the production of pure single photons and thus eliminates the vacuum contribution. This is done by verifying a XPM related phase shift with a Mach-Zehnder interferometer.Comment: 8 pages, 8 EPS figures, RevTeX4. Following changes have been made in v.3: Title and abstract slightly changed; numerous minor revisions and clarifications within the text; an appendix with three new figures has been added. In version v4 we have included a supplementary analysis of our scheme that takes into account absorption losses. Our analysis is heuristic and based on a phenomenological model, which is independent of the physical realization of the proposed scheme. We have estimated upper bounds up to which absorption losses can be tolerated, so as our scheme to improve the efficiency of single photon sources still works. Accepted for publication in Phys. Rev.

The Economic Impact of Social Ties: Evidence from German Reunification

We use the fall of the Berlin Wall in 1989 to show that personal relationships which individuals maintain for non-economic reasons can be an important determinant of regional economic growth. We show that West German households who have social ties to East Germany in 1989 experience a persistent rise in their personal incomes after the fall of the Berlin Wall. Moreover, the presence of these households significantly affects economic performance at the regional level: it increases the returns to entrepreneurial activity, the share of households who become entrepreneurs, and the likelihood that firms based within a given West German region invest in East Germany. As a result, West German regions which (for idiosyncratic reasons) have a high concentration of households with social ties to the East exhibit substantially higher growth in income per capita in the early 1990s. A one standard deviation rise in the share of households with social ties to East Germany in 1989 is associated with a 4.6 percentage point rise in income per capita over six years. We interpret our findings as evidence of a causal link between social ties and regional economic development.economic development, German reuni cation, networks, social ties

Refractive error changes in cortical, nuclear, and posterior subcapsular cataracts

AIMS: To determine the effect of the three main morphological types of cataract on refractive error. METHODS: Data were prospectively collected from 77 subjects (age 67 (SD 8) years) with one morphological type of cataract. 34 had cortical, 21 had nuclear, and 21 had posterior subcapsular cataract. 22 subjects with clear lenses (60 (7) years) were recruited as controls. The spherical equivalent and astigmatic vector change between spectacle correction and optimal refraction were calculated. RESULTS: The cortical cataract group showed a significant astigmatic change of 0.71 (0.67) D (mean (1 SD)) compared to the control group (0.24 (0.20) D), with 24% outside the 95% confidence limit (0.63 D). The nuclear cataract group showed a significant myopic shift of -0.38 (0.60) D compared to the control group (+0.02 (0.21) D), with 52% beyond the minus 95% confidence limit (-0.39 D). CONCLUSION: A quarter of subjects with cortical cataract showed larger changes in astigmatism than subjects with clear lenses. This is probably because of the localised refractive index changes along cortical spoke opacities within the pupillary area. The well known myopic shift of nuclear cataract was also demonstrated

Safety assessment of the Jerónimos church in Lisbon

Advanced (non-linear) analysis of historical constructions represents a key contribution for the understanding of the architectural heritage. The safety of a famous Portuguese church is addressed using two different finite element models for the nave and the transept. The complexity of the ornaments of the vaults calls for a mix of volume, curved shell and beam elements. A sensitivity study and a simplified buckling analysis are also carried out to provide further insight in the results. The analysis indicates that the safety level of the structure is low, probably due to the uniqueness of the structural conception.Fundação para a Ciência e a Tecnologia - POCTI-ECM-38071-2001

Plasma-tail activity and the interplanetary medium at Halley's Comet during Armada Week: 6-14 March 1986

The encounters of five spacecraft with Halley's Comet during 6-14 March 1986 offered a unique opportunity to calibrate the solar-wind interaction with cometary plasmas as recorded by remote wide-field and narrow-field/narrowband imaging. Perhaps not generally recognized in the comet community is the additional opportunity offered by the Halley Armada to study the structure of the solar-wind and interplanetary magnetic field (IMF) in three dimensions using five sets of data obtained over similar time intervals and heliocentric distances, but at somewhat different heliolatitudes. In fact, the two problems, i.e., comet physics and the structure of the interplanetary medium, are coupled if one wants to understand what conditions pertained at the comet between the encounters. This relationship is discussed

Optimal lossy quantum interferometry in phase space

We analyse the phase space representation of the optimal measurement of a phase shift in an interferometer with equal photon loss in both its arms. In the local phase estimation scenario with a fixed number of photons, we identify features of the spin Wigner function that warrant sub-shot noise precision, and discuss their sensitivity to losses. We derive the asymptotic form of an integral kernel describing the process of photon loss in the phase space in the limit of large photon numbers. The analytic form of this kernel allows one to assess the ultimate precision limit for a lossy interferometer. We also provide a general lower bound on the quantum Fisher information in terms of spin Wigner functions.Comment: 20 pages, 6 figures, published versio