103,998 research outputs found

    Education Policies to Revive a Stagnant Economy: The Case of Sub- Saharan Africa

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    In this paper, we argue that the condition of education and the economy of the low performing sub-Saharan African countries can be characterized as a stagnant steady state -- a "trap". We present a simple heterogeneous-agent model in which high costs of education relative to income and the skill premium can cause the economy to be trapped in such a steady state with minimal educational attainment. We calibrate the model to available data from the sub-Saharan African countries to study policies that could potentially free these trapped economies and set them on a path to a higher steady state. We find that a tax and subsidy scheme that redistributes resources at the trap from poor households with lower ability children to those with higher ability children can pry the economy out of the trap, thus freeing it from dependence on foreign aid in order to achieve the same goal. In addition to the direct cost, a portion of the indirect cost also needs to be subsidized. Moreover, such a policy outperforms the abolition of child labor and the institution and enforcement of compulsory education laws when expenditure neutral welfare comparisons are made.Dynamic heterogeneous-agent models, Economic stagnation, Education subsidies, Calibration of a trap

    Linear Response Theory and Optical Conductivity of Floquet Topological Insulators

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    Motivated by the quest for experimentally accessible dynamical probes of Floquet topological insulators, we formulate the linear response theory of a periodically driven system. We illustrate the applications of this formalism by giving general expressions for optical conductivity of Floquet systems, including its homodyne and heterodyne components and beyond. We obtain the Floquet optical conductivity of specific driven models, including two-dimensional Dirac material such as the surface of a topological insulator, graphene, and the Haldane model irradiated with circularly or linearly polarized laser, as well as semiconductor quantum well driven by an ac potential. We obtain approximate analytical expressions and perform numerically exact calculations of the Floquet optical conductivity in different scenarios of the occupation of the Floquet bands, in particular, the diagonal Floquet distribution and the distribution obtained after a quench. We comment on experimental signatures and detection of Floquet topological phases using optical probes.Comment: 16 pages, 10 figure

    Computational binding mechanism of Mycobacterium tuberculosis UDP-NAG enolpyruvyl transferase (MurA) with inhibitors fosfomycin, cyclic disulfide analog RWJ-3981, pyrazolopyrimidine analog RWJ-110192, purine analog RWJ-140998, 5-sulfonoxy-anthranilic aci

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    Worldwide, tuberculosis (TB) remains the most frequent and important infectious disease causing morbidity and death. One-third of the world's population is infected with Mycobacterium tuberculosis (Mtb), the etiologic agent of TB. In this context, TB is in the top three, with malaria and HIV being the leading causes of death from a single infectious agent, and about two million deaths are attributable to TB annually. The bacterial enzyme MurA catalyzes the transfer of enolpyruvate from phosphoenolpyruvate (PEP) to uridine diphospho-N-acetylglucosamine (UNAG), which is the first committed step of bacterial cell wall biosynthesis. In this work, 3D structural model of Mtb-MurA enzyme has been developed, for the first time, by homology modeling and molecular dynamics simulation techniques. The model provided clear insight in its structure features, i.e. substrate binding pocket, and common docking site. Multiple sequence alignment and 3D structure model provided the putative substrate binding pocket of Mtb-MurA with respect to E.coli MurA. This analysis was helpful in identifying the binding sites and molecular function of the MurA homologue. Molecular docking study was performed on this 3D structural model, using different classes of inhibitors like fosfomycin, cyclic disulfide analog RWJ-3981, pyrazolopyrimidine analog RWJ-110192, purine analog RWJ-140998, 5-sulfonoxy-anthranilic acid derivatives T6361, T6362 and the results showed that the 5-sulfonoxyanthranilic acid derivatives is showed best interaction compared with other inhibitor, taking in to this we also design a new efficient analogs of T6361 and T6362 which are showed even better interaction with Mtb-MurA than the parental5-sulfonoxy-anthranilic acid derivatives. Further the comparative molecular electrostatic potential and cavity depth analysis of Mtb-MurA suggested several important differences in its substrate and inhibitor binding pocket. Such differences could be exploited in the future for designing of a more specific inhibitor for Mtb-MurA enzym

    Electron-hole coexistence in disordered graphene probed by high-field magneto-transport

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    We report on magneto-transport measurement in disordered graphene under pulsed magnetic field of up to 57T. For large electron or hole doping, the system displays the expected anomalous Integer Quantum Hall Effect (IQHE) specific to graphene up to filling factor ν=2\nu=2. In the close vicinity of the charge neutrality point, the system breaks up into co-existing puddles of holes and electrons, leading to a vanishing Hall and finite longitudinal resistance with no hint of divergence at very high magnetic field. Large resistance fluctuations are observed near the Dirac point. They are interpreted as the the natural consequence of the presence of electron and hole puddles. The magnetic field at which the amplitude of the fluctuations are the largest is directly linked to the mean size of the puddles

    Spin-spin Correlation in Some Excited States of Transverse Ising Model

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    We consider the transverse Ising model in one dimension with nearest-neighbour interaction and calculate exactly the longitudinal spin-spin correlation for a class of excited states. These states are known to play an important role in the perturbative treatment of one-dimensional transverse Ising model with frustrated second-neighbour interaction. To calculate the correlation, we follow the earlier procedure of Wu, use Szego's theorem and also use Fisher-Hartwig conjecture. The result is that the correlation decays algebraically with distance (nn) as 1/n1/\surd n and is oscillatory or non-oscillatory depending on the magnitude of the transverse field.Comment: 5 pages, 1 figur

    The Many Electron Ground State of the Adiabatic Holstein Model in Two and Three Dimensions

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    We present the complete ground state phase diagram of the Holstein model in two and three dimension considering the phonon variables to be classical. We first establish the overall structure of the phase diagram by using exact diagonalisation based Monte Carlo (ED-MC) on small lattices and then use a new ``travelling cluster'' approximation (TCA) for annealing the phonon degrees of freedom on large lattices. The phases that emerge include a Fermi liquid (FL), with no lattice distortions, an insulating polaron liquid (PL) at strong coupling, and a charge ordered insulating (COI) phase around half- filling. The COI phase is separated from the Fermi liquid by a regime of phase coexistence whose width grows with increasing electron-phonon coupling. We provide results on the electronic density of states, the COI order parameter, and the spatial organisation of polaronic states, for arbitrary density and electron-phonon coupling. The results highlight the crucial role of spatial correlations in this strong coupling problem.Comment: Final versio
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