The model constraints from the observed trends for the quasi-periodic oscillation in RE J1034+396

We analyze the time variability of the X-ray emission of RE J1034+396 -- an active galactic nucleus with the first firm detection of a quasi-periodic oscillations (QPO). Based on the results of a wavelet analysis, we find a drift in the QPO central frequency. The change in the QPO frequency correlates with the change in the X-ray flux with a short time delay. The data specifically suggest a linear dependence between the QPO period and the flux, and this gives important constraints on the QPO models. In particular, it excludes explanation in terms of the orbiting hot spot model close to a black hole. Linear structures such as shocks, spiral waves, or very distant flares are favored.Comment: Astronomy & Astrophysics, in pres

QPO in RE J1034+396: model constraints from observed trends

We analyze the time variability of the X-ray emission of RE J1034+396, an active galactic nucleus with the first firm detection of a quasi-periodic oscillations (QPO). Based on the results of a wavelet analysis, we find a drift in the QPO central frequency. The change inthe QPO frequency correlates with the change in the X-ray flux with a short time delay. Linear structures such as shocks, spiral waves, orvery distant flares seem to be a favored explanation for this particular QPO event.Comment: to appear in the proceedings to "The Central Kiloparsec in Galactic Nuclei (AHAR2011)", Journal of Physics: Conference Series (JPCS), IOP Publishin

Kinetic hierarchy and propagation of chaos in biological swarm models

We consider two models of biological swarm behavior. In these models, pairs of particles interact to adjust their velocities one to each other. In the first process, called 'BDG', they join their average velocity up to some noise. In the second process, called 'CL', one of the two particles tries to join the other one's velocity. This paper establishes the master equations and BBGKY hierarchies of these two processes. It investigates the infinite particle limit of the hierarchies at large time-scale. It shows that the resulting kinetic hierarchy for the CL process does not satisfy propagation of chaos. Numerical simulations indicate that the BDG process has similar behavior to the CL process

Modeling the time-resolved quasi-periodic oscillations in AGNs

Observation of the bright Seyfert 1 galaxy RE J1034+396 is believed to demonstrate a drift of the central period of the Quasi Periodic Oscillation (QPO) linearly correlated with the temporary X-ray luminosity. We show, using a specific scenario of the oscillation mechanism in black hole accretion disc, that modeling such correlated trends puts very strong constraints on the nature of this oscillation and the characteristic features of the hot flow in Active Galactic Nuclei (AGN). In our model, QPO oscillations are due to the oscillations of the shock formed in the low angular momentum hot accretion flow, and the variation of the shock location corresponds to the observed changes in the QPO period and the X-ray flux. In this scenario, change in the shock location caused by perturbation of the flow angular momentum is compatible with the trends observed in RE J1034+396, whereas the perturbation of the specific flow energy results in too strong flux response to the change of the oscillation period. Using a complete general relativistic framework to study the accretion flow in the Kerr metric, we discuss the role of the black hole spin in the period drift. Future missions are expected to bring more active galaxies with time-resolved quasi-periodic oscillations so similar quantitative study for other QPO scenarios will be necessary.Comment: Final version accepted for publication in MNRAS. Several modifications made. Eight pages. Six colour figure

Quasiperiodic oscillations in a strong gravitational field around neutron stars testing braneworld models

The strong gravitational field of neutron stars in the brany universe could be described by spherically symmetric solutions with a metric in the exterior to the brany stars being of the Reissner-Nordstrom type containing a brany tidal charge representing the tidal effect of the bulk spacetime onto the star structure. We investigate the role of the tidal charge in orbital models of high-frequency quasiperiodic oscillations (QPOs) observed in neutron star binary systems. We focus on the relativistic precession model. We give the radial profiles of frequencies of the Keplerian (vertical) and radial epicyclic oscillations. We show how the standard relativistic precession model modified by the tidal charge fits the observational data, giving estimates of the allowed values of the tidal charge and the brane tension based on the processes going in the vicinity of neutron stars. We compare the strong field regime restrictions with those given in the weak-field limit of solar system experiments.Comment: 26 pages, 6 figure

Voice-based assessments of trustworthiness, competence, and warmth in blind and sighted adults

The study of voice perception in congenitally blind individuals allows researchers rare insight into how a lifetime of visual deprivation affects the development of voice perception. Previous studies have suggested that blind adults outperform their sighted counterparts in low-level auditory tasks testing spatial localization and pitch discrimination, as well as in verbal speech processing; however, blind persons generally show no advantage in nonverbal voice recognition or discrimination tasks. The present study is the first to examine whether visual experience influences the development of social stereotypes that are formed on the basis of nonverbal vocal characteristics (i.e., voice pitch). Groups of 27 congenitally or early-blind adults and 23 sighted controls assessed the trustworthiness, competence, and warmth of men and women speaking a series of vowels, whose voice pitches had been experimentally raised or lowered. Blind and sighted listeners judged both men’s and women’s voices with lowered pitch as being more competent and trustworthy than voices with raised pitch. In contrast, raised-pitch voices were judged as being warmer than were lowered-pitch voices, but only for women’s voices. Crucially, blind and sighted persons did not differ in their voice-based assessments of competence or warmth, or in their certainty of these assessments, whereas the association between low pitch and trustworthiness in women’s voices was weaker among blind than sighted participants. This latter result suggests that blind persons may rely less heavily on nonverbal cues to trustworthiness compared to sighted persons. Ultimately, our findings suggest that robust perceptual associations that systematically link voice pitch to the social and personal dimensions of a speaker can develop without visual input

Whole-genome analyses reveal gene content differences between nontypeable Haemophilus influenzae isolates from chronic obstructive pulmonary disease compared to other clinical phenotypes

Nontypeable Haemophilus influenzae (NTHi) colonizes human upper respiratory airways and plays a key role in the course and pathogenesis of acute exacerbations of chronic obstructive pulmonary disease (COPD). Currently, it is not possible to distinguish COPD isolates of NTHi from other clinical isolates of NTHi using conventional genotyping methods. Here, we analysed the core and accessory genome of 568 NTHi isolates, including 40 newly sequenced isolates, to look for genetic distinctions between NTHi isolates from COPD with respect to other illnesses, including otitis media, meningitis and pneumonia. Phylogenies based on polymorphic sites in the core-genome did not show discrimination between NTHi strains collected from different clinical phenotypes. However, pan-genome-wide association studies identified 79 unique NTHi accessory genes that were significantly associated with COPD. Furthermore, many of the COPD-related NTHi genes have known or predicted roles in virulence, transmembrane transport of metal ions and nutrients, cellular respiration and maintenance of redox homeostasis. This indicates that specific genes may be required by NTHi for its survival or virulence in the COPD lung. These results advance our understanding of the pathogenesis of NTHi infection in COPD lungs

The structure and X-ray radiation spectra of illuminated accretion disks in AGN. III. Modeling fractional variability

[abridged] Extending the work of Czerny et al. (2004), we model the fractional variability amplitude due to distributions of hot spots co-orbiting on the accretion disk around a supermassive black hole. From defined radial distributions, our code samples random positions for the hot spots across the disk. The local spot emission is computed as reprocessed radiation coming from a compact primary source above the disk. The structure of the hot spot and the anisotropy of the re-emission are taken into account. We compute the fractional variability spectra expected from such spot ensembles and investigate dependencies on the parameters describing the radial spot distribution. We consider the fractional variability F_var with respect to the spectral mean and also the so-called point-to-point F_pp. Our method includes relativistic corrections for the curved space-time; the black hole angular momentum is a free parameter and subject to the fitting procedure. We confirm that the rms-variability spectra involve intrinsic randomness at a significant level when the number of flares appearing during the total observation time is too small. Furthermore, F_var is not always compatible with F_pp. For MCG -6-30-15, we can reproduce the short-timescale variability and model the suppressed variability in the energy range of the Kalpha line without any need to postulate reprocessing farther away from the center. An increasing rate of energy production by the flares toward the center of the disk, a fast rotation of the central black hole, and considerable suppression of the primary flare emission are required. The modeled line remains consistent with the measured equivalent width of the iron Kalpha line complex.Comment: 15 pages, 12 figures, published version, Astronomy and Astrophysics, some minor changes were made, namely concerning the motivation of the error calculation in Eq. (6). The abstract is abridged compared to the published versio

Involvement of Dopamine Receptors in Binge Methamphetamine-Induced Activation of Endoplasmic Reticulum and Mitochondrial Stress Pathways

Single large doses of methamphetamine (METH) cause endoplasmic reticulum (ER) stress and mitochondrial dysfunctions in rodent striata. The dopamine D1 receptor appears to be involved in these METH-mediated stresses. The purpose of this study was to investigate if dopamine D1 and D2 receptors are involved in ER and mitochondrial stresses caused by single-day METH binges in the rat striatum. Male Sprague-Dawley rats received 4 injections of 10 mg/kg of METH alone or in combination with a putative D1 or D2 receptor antagonist, SCH23390 or raclopride, respectively, given 30 min prior to each METH injection. Rats were euthanized at various timepoints afterwards. Striatal tissues were used in quantitative RT-PCR and western blot analyses. We found that binge METH injections caused increased expression of the pro-survival genes, BiP/GRP-78 and P58IPK, in a SCH23390-sensitive manner. METH also caused up-regulation of ER-stress genes, Atf2, Atf3, Atf4, CHOP/Gadd153 and Gadd34. The expression of heat shock proteins (HSPs) was increased after METH injections. SCH23390 completely blocked induction in all analyzed ER stress-related proteins that included ATF3, ATF4, CHOP/Gadd153, HSPs and caspase-12. The dopamine D2-like antagonist, raclopride, exerted small to moderate inhibitory influence on some METH-induced changes in ER stress proteins. Importantly, METH caused decreases in the mitochondrial anti-apoptotic protein, Bcl-2, but increases in the pro-apoptotic proteins, Bax, Bad and cytochrome c, in a SCH23390-sensitive fashion. In contrast, raclopride provided only small inhibition of METH-induced changes in mitochondrial proteins. These findings indicate that METH-induced activation of striatal ER and mitochondrial stress pathways might be more related to activation of SCH23390-sensitive receptors