Aharonov-Bohm interference in the presence of metallic mesoscopic cylinders

This work studies the interference of electrons in the presence of a line of magnetic flux surrounded by a normal-conducting mesoscopic cylinder at low temperature. It is found that, while there is a supplementary phase contribution from each electron of the mesoscopic cylinder, the sum of these individual supplementary phases is equal to zero, so that the presence of a normal-conducting mesoscopic ring at low temperature does not change the Aharonov-Bohm interference pattern of the incident electron. It is shown that it is not possible to ascertain by experimental observation that the shielding electrons have responded to the field of an incident electron, and at the same time to preserve the interference pattern of the incident electron. It is also shown that the measuring of the transient magnetic field in the region between the two paths of an electron interference experiment with an accuracy at least equal to the magnetic field of the incident electron generates a phase uncertainty which destroys the interference pattern.Comment: 15 pages, 5 Postscript figure

A Dynamic Single E-Beam Short/Open Testing Technique

Several electron beam techniques for electrical testing of interconnection modules have been presented by different authors in recent years. Most techniques use two or more electron beam energies to establish a charging and a non-loading reading mode. The present paper discusses the feasibility of employing the same beam energy for charging contact pads and reading pad potentials. This avoids the necessity of high voltage switching as used for altering the beam energy. A switching time of 100 us between 2 kV and 4 kV beam voltage which is restricted to this range has been reported earlier. Without switching, higher beam energies may be used with smaller transition times between charging and reading of the test pads

Oxytocin receptor gene polymorphisms are associated with human directed social behavior in dogs (Canis familiaris)

The oxytocin system has a crucial role in human sociality; several results prove that polymorphisms of the oxytocin receptor gene are related to complex social behaviors in humans. Dogs' parallel evolution with humans and their adaptation to the human environment has made them a useful species to model human social interactions. Previous research indicates that dogs are eligible models for behavioral genetic research, as well. Based on these previous findings, our research investigated associations between human directed social behaviors and two newly described (−212AG, 19131AG) and one known (rs8679684) single nucleotide polymorphisms (SNPs) in the regulatory regions (5′ and 3′ UTR) of the oxytocin receptor gene in German Shepherd (N = 104) and Border Collie (N = 103) dogs. Dogs' behavior traits have been estimated in a newly developed test series consisting of five episodes: Greeting by a stranger, Separation from the owner, Problem solving, Threatening approach, Hiding of the owner. Buccal samples were collected and DNA was isolated using standard protocols. SNPs in the 3′ and 5′ UTR regions were analyzed by polymerase chain reaction based techniques followed by subsequent electrophoresis analysis. The gene–behavior association analysis suggests that oxytocin receptor gene polymorphisms have an impact in both breeds on (i) proximity seeking towards an unfamiliar person, as well as their owner, and on (ii) how friendly dogs behave towards strangers, although the mediating molecular regulatory mechanisms are yet unknown. Based on these results, we conclude that similarly to humans, the social behavior of dogs towards humans is influenced by the oxytocin system

A monolithically integrated silicon modulator with a 10 Gb/s 5 V pp or 5.6 V pp driver in 0.25 μm SiGe:C BiCMOS

This paper presents as a novelty a fully monolithically integrated 10 Gb/s silicon modulator consisting of an electrical driver plus optical phase modulator in 0.25 μm SiGe:C BiCMOS technology on one chip, where instead of a SOI CMOS process (only MOS transistors) a SiGe BiCMOS process (MOS transistors and fast SiGe bipolar transistors) is implemented. The fastest bipolar transistors in the BiCMOS product line used have a transit frequency of f t ≈ 120 GHz and a collector-emitter breakdown voltage of BV CE0 = 2.2 V (IHP SG25H3). The main focus of this paper will be given to the electronic drivers, where two driver variants are implemented in the test chips. Circuit descriptions and simulations, which treat the influences of noise and bond wires, are presented. Measurements at separate test chips for the drivers show that the integrated driver variant one has a low power consumption in the range of 0.66 to 0.68 W but a high gain of S 21 = 37 dB. From the large signal point of view this driver delivers an inverted as well as a non-inverted output data signal between 0 and 2.5 V (5 V pp differential). Driver variant one is supplied with 2.5 V and with 3.5 V. Bit-error-ratio (BER) measurements resulted in a BER better than 10 −12 for voltage differences of the input data stream down to 50 mV pp . Driver variant two, which is an adapted version of driver variant one, is supplied with 2.5 and 4.2 V, consumes 0.83 to 0.87 W, delivers a differential data signal with 5.6 V pp at the output and has a gain of S 21 = 40 dB. The chip of the fully integrated modulator occupies an area of 12.3 mm 2 due to the photonic components. Measurements with a 240 mV pp electrical input data stream, 1.25 V input common-mode voltage and for an optical input wavelength of 1540 nm resulted in an extinction ratio of 3.3 dB for 1 mm long RF phase shifters in each modulator arm driven by driver variant one and a DC tuning voltage of 1.2 V. The extinction ratio was 8.4 dB at a DC tuning voltage of 7 V for a device with 2 mm long RF phase shifters in each arm and driver variant two

ICOS regulates the generation and function of human CD4+ Treg in a CTLA-4 dependent manner

Inducible co-stimulator (ICOS) is a member of CD28/Cytotoxic T-lymphocyte Antigen-4 (CTLA-4) family and broadly expressed in activated CD4+ T cells and induced regulatory CD4+ T cells (CD4+ iTreg). ICOS-related signal pathway could be activated by the interaction between ICOS and its ligand (ICOSL). In our previous work, we established a cost-effective system to generate a novel human allo-antigen specific CD4hi Treg by co-culturing their naïve precursors with allogeneic CD40-activated B cells in vitro. Here we investigate the role of ICOS in the generation and function of CD4hi Treg by interrupting ICOS-ICOSL interaction with ICOS-Ig. It is found that blockade of ICOS-ICOSL interaction impairs the induction and expansion of CD4hi Treg induced by allogeneic CD40-activated B cells. More importantly, CD4hi Treg induced with the addition of ICOS-Ig exhibits decreased suppressive capacity on alloantigen-specific responses. Dysfunction of CD4hi Treg induced with ICOS-Ig is accompanied with its decreased exocytosis and surface CTLA-4 expression. Through inhibiting endocytosis with E64 and pepstatin A, surface CTLA-4 expression and suppressive functions of induced CD4hi Treg could be partly reversed. Conclusively, our results demonstrate the beneficial role of ICOS-ICOSL signal pathway in the generation and function of CD4hi Treg and uncover a novel relationship between ICOS and CTLA-4. © 2013 zheng et al.published_or_final_versio

ARIADNE: A Scientific Navigator to Find Your Way Through the Resource Labyrinth of Psychological Sciences

Performing high-quality research is a challenging endeavor, especially for early career researchers, in many fields of psychological science. Most research is characterized by experiential learning, which can be time-consuming, error-prone, and frustrating. Although most institutions provide selected resources to help researchers with their projects, these resources are often expensive, spread out, hard to find, and difficult to compare with one another in terms of reliability, validity, usability, and practicability. A comprehensive overview of resources that are useful for researchers in psychological science is missing. To address this issue, we created ARIADNE: a living and interactive resource navigator that helps to use and search a dynamically updated database of resources ( https://igor-biodgps.github.io/ARIADNE ). In this tutorial, we aim to guide researchers through a standard research project using ARIADNE along the way. The open-access database covers a growing list of resources useful for each step of a research project, from the planning and designing of a study, over the collection and analysis of the data, to the writing and disseminating of the findings. We provide (a) a step-by-step guide on how to perform a research project (in the fields of biological psychology and neuroscience as a case example but with broad application to neighboring fields) and (b) an overview of resources that are useful at different project steps. By explicitly highlighting open-access and open-source resources, we level the playing field for researchers from underprivileged countries or institutions, thereby facilitating open, fair, and reproducible research in the psychological sciences

Exploration of key stakeholders' preferences for pre-hospital physiologic monitoring by emergency rescue services

Peer reviewedPostprintPostprin

Enhancing precision in human neuroscience

Human neuroscience has always been pushing the boundary of what is measurable. During the last decade, concerns about statistical power and replicability - in science in general, but also specifically in human neuroscience - have fueled an extensive debate. One important insight from this discourse is the need for larger samples, which naturally increases statistical power. An alternative is to increase the precision of measurements, which is the focus of this review. This option is often overlooked, even though statistical power benefits from increasing precision as much as from increasing sample size. Nonetheless, precision has always been at the heart of good scientific practice in human neuroscience, with researchers relying on lab traditions or rules of thumb to ensure sufficient precision for their studies. In this review, we encourage a more systematic approach to precision. We start by introducing measurement precision and its importance for well-powered studies in human neuroscience. Then, determinants for precision in a range of neuroscientific methods (MRI, M/EEG, EDA, Eye-Tracking, and Endocrinology) are elaborated. We end by discussing how a more systematic evaluation of precision and the application of respective insights can lead to an increase in reproducibility in human neuroscience

Integration of high performance silicon optical modulators

We present our recent work on high speed silicon optical modulators developed within the UK silicon photonics and HELIOS projects. Examples of their integration with other photonic and electronic elements are also presented