5,291 research outputs found

    Further research in double interaction: the simultaneous conduct of man–man and man–computer interaction

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    Double interaction is the abbreviation for the simultaneous conduct of man–man interaction on the one hand, and man–computer interaction, on the other. It is a recent development—certainly in this country—and roughly follows chronologically, the advent of the computer, and subsequently, the development of man–computer interaction… The general concept of double interaction is new and extends over a wide variety of situations. The objectives of research in this field are therefore necessarily different, from the painstaking systematic research devoted to a small component feature derived from a well-established field, which one often sees in doctoral dissertations. For double interaction, the lack of an established literature as well as far-ranging implications associated with too rapid an application of a new technology, leads to a different set of objectives. The need here is for an outline of the major parameters relating to double interaction over a wide variety of situations, how these parameters may interrelate, and how one or more of these parameters may be exploited to give rise to effective planning and application of double interaction. The need therefore is more of a general nature, the overall objective being the provision of the means for understanding, designing, and implementing effective double interaction situations

    Lipid membranes for membrane proteins

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    Andreas Kukol, ‘Lipid membranes for membrane proteins in Molecular Modeling of Proteins (Clifton: Humana Press/Sringer, 2015), ISBN: 978-1-4939-1464-7, e-BOOK ISBN: 978-1-4939-1465-4Peer reviewe

    Systematic Review of the Performance of Noninvasive Tests in Diagnosing Bladder Outlet Obstruction in Men with Lower Urinary Tract Symptoms

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    Context: Several noninvasive tests have been developed for diagnosing bladder outlet obstruction (BOO) in men to avoid the burden and morbidity associated with invasive urodynamics. The diagnostic accuracy of these tests, however, remains uncertain. Objective: To systematically review available evidence regarding the diagnostic accuracy of noninvasive tests in diagnosing BOO in men with lower urinary tract symptoms (LUTS) using a pressure-flow study as the reference standard. Evidence acquisition: The EMBASE, MEDLINE, Cochrane Database of Systematic Reviews, Cochrane Central, Google Scholar, and WHO International Clinical Trials Registry Platform Search Portal databases were searched up to May 18, 2016. All studies reporting diagnostic accuracy for noninvasive tests for BOO or detrusor underactivity in men with LUTS compared to pressure-flow studies were included. Two reviewers independently screened all articles, searched the reference lists of retrieved articles, and performed the data extraction. The quality of evidence and risk of bias were assessed using the QUADAS-2 tool. Evidence synthesis: The search yielded 2774 potentially relevant reports. After screening titles and abstracts, 53 reports were retrieved for full-text screening, of which 42 (recruiting a total of 4444 patients) were eligible. Overall, the results were predominantly based on findings from nonrandomised experimental studies and, within the limits of such study designs, the quality of evidence was typically moderate across the literature. Differences in noninvasive test threshold values and variations in the urodynamic definition of BOO between studies limited the comparability of the data. Detrusor wall thickness (median sensitivity 82%, specificity 92%), near- infrared spectroscopy (median sensitivity 85%, specificity 87%), and the penile cuff test (median sensitivity 88%, specificity 75%) were all found to have high sensitivity and specificity in diagnosing BOO. Uroflowmetry with a maximum flow rate of 10 mm was reported to have similar diagnostic accuracy, with median sensitivity of 68% and specificity of 75%. Conclusions: According to the literature, a number of noninvasive tests have high sensitivity and specificity in diagnosing BOO in men. However, although the majority of studies have a low overall risk of bias, the available evidence is limited by heterogeneity. While several tests have shown promising results regarding noninvasive assessment of BOO, invasive urodynamics remain the gold standard. Patient summary: Urodynamics is an accurate but potentially uncomfortable test for patients in diagnosing bladder problems such as obstruction. We performed a thorough and comprehensive review of the literature to determine if there were less uncomfortable but equally effective alternatives to urodynamics for diagnosing bladder problems. We found that some simple tests appear to be promising, although they are not as accurate. Further research is needed before these tests are routinely used in place of urodynamics. (C) 2016 European Association of Urology. Published by Elsevier B.V. All rights reserved.Peer reviewe

    Measurement of proton electromagnetic form factors in e+eppˉe^+e^- \to p\bar{p} in the energy region 2.00-3.08 GeV

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    The process of e+eppˉe^+e^- \rightarrow p\bar{p} is studied at 22 center-of-mass energy points (s\sqrt{s}) from 2.00 to 3.08 GeV, exploiting 688.5~pb1^{-1} of data collected with the BESIII detector operating at the BEPCII collider. The Born cross section~(σppˉ\sigma_{p\bar{p}}) of e+eppˉe^+e^- \rightarrow p\bar{p} is measured with the energy-scan technique and it is found to be consistent with previously published data, but with much improved accuracy. In addition, the electromagnetic form-factor ratio (GE/GM|G_{E}/G_{M}|) and the value of the effective (Geff|G_{\rm{eff}}|), electric (GE|G_E|) and magnetic (GM|G_M|) form factors are measured by studying the helicity angle of the proton at 16 center-of-mass energy points. GE/GM|G_{E}/G_{M}| and GM|G_M| are determined with high accuracy, providing uncertainties comparable to data in the space-like region, and GE|G_E| is measured for the first time. We reach unprecedented accuracy, and precision results in the time-like region provide information to improve our understanding of the proton inner structure and to test theoretical models which depend on non-perturbative Quantum Chromodynamics

    Search for the decay J/ψγ+invisibleJ/\psi\to\gamma + \rm {invisible}

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    We search for J/ψJ/\psi radiative decays into a weakly interacting neutral particle, namely an invisible particle, using the J/ψJ/\psi produced through the process ψ(3686)π+πJ/ψ\psi(3686)\to\pi^+\pi^-J/\psi in a data sample of (448.1±2.9)×106(448.1\pm2.9)\times 10^6 ψ(3686)\psi(3686) decays collected by the BESIII detector at BEPCII. No significant signal is observed. Using a modified frequentist method, upper limits on the branching fractions are set under different assumptions of invisible particle masses up to 1.2  GeV/c2\mathrm{\ Ge\kern -0.1em V}/c^2. The upper limit corresponding to an invisible particle with zero mass is 7.0×107\times 10^{-7} at the 90\% confidence level

    Search for the rare decays B0J/ψγB^{0}\to J/\psi \gamma and Bs0J/ψγB^{0}_{s} \to J/\psi \gamma

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    A search for the rare decay of a B0B^{0} or Bs0B^{0}_{s} meson into the final state J/ψγJ/\psi\gamma is performed, using data collected by the LHCb experiment in pppp collisions at s=7\sqrt{s}=7 and 88 TeV, corresponding to an integrated luminosity of 3 fb1^{-1}. The observed number of signal candidates is consistent with a background-only hypothesis. Branching fraction values larger than 1.7×1061.7\times 10^{-6} for the B0J/ψγB^{0}\to J/\psi\gamma decay mode are excluded at 90% confidence level. For the Bs0J/ψγB^{0}_{s}\to J/\psi\gamma decay mode, branching fraction values larger than 7.4×1067.4\times 10^{-6} are excluded at 90% confidence level, this is the first branching fraction limit for this decay.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2015-044.htm

    A model-independent confirmation of the Z(4430)Z(4430)^- state

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    The decay B0ψ(2S)K+πB^0\to \psi(2S) K^+\pi^- is analyzed using 3 fb1\rm 3~fb^{-1} of pppp collision data collected with the LHCb detector. A model-independent description of the ψ(2S)π\psi(2S) \pi mass spectrum is obtained, using as input the KπK\pi mass spectrum and angular distribution derived directly from data, without requiring a theoretical description of resonance shapes or their interference. The hypothesis that the ψ(2S)π\psi(2S)\pi mass spectrum can be described in terms of KπK\pi reflections alone is rejected with more than 8σ\sigma significance. This provides confirmation, in a model-independent way, of the need for an additional resonant component in the mass region of the Z(4430)Z(4430)^- exotic state.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2015-038.htm

    A study of CPCP violation in BDhB^\mp \rightarrow Dh^\mp (h=K,πh=K,\pi) with the modes DKπ±π0D \rightarrow K^\mp \pi^\pm \pi^0, Dπ+ππ0D \rightarrow \pi^+\pi^-\pi^0 and DK+Kπ0D \rightarrow K^+K^-\pi^0

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    An analysis of the decays of BDKB^\mp \rightarrow D K^\mp and BDπB^\mp \rightarrow D \pi^\mp is presented in which the DD meson is reconstructed in the three-body final states Kπ±π0K^\mp \pi^\pm \pi^0, π+ππ0\pi^+ \pi^- \pi^0 and K+Kπ0K^+ K^- \pi^0. Using data from LHCb corresponding to an integrated luminosity of 3.0 fb1^{-1} of pppp collisions, measurements of several CPCP observables are performed. First observations are obtained of the suppressed ADS decay B[πK±π0]DπB^\mp \rightarrow [\pi^\mp K^\pm \pi^0]_D \pi^\mp and the quasi-GLW decay B[K+Kπ0]DπB^\mp \rightarrow [K^+ K^- \pi^0]_D \pi^\mp. The results are interpreted in the context of the unitarity triangle angle γ\gamma and related parameters
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