Predicting Intermediate Storage Performance for Workflow Applications

Configuring a storage system to better serve an application is a challenging task complicated by a multidimensional, discrete configuration space and the high cost of space exploration (e.g., by running the application with different storage configurations). To enable selecting the best configuration in a reasonable time, we design an end-to-end performance prediction mechanism that estimates the turn-around time of an application using storage system under a given configuration. This approach focuses on a generic object-based storage system design, supports exploring the impact of optimizations targeting workflow applications (e.g., various data placement schemes) in addition to other, more traditional, configuration knobs (e.g., stripe size or replication level), and models the system operation at data-chunk and control message level. This paper presents our experience to date with designing and using this prediction mechanism. We evaluate this mechanism using micro- as well as synthetic benchmarks mimicking real workflow applications, and a real application.. A preliminary evaluation shows that we are on a good track to meet our objectives: it can scale to model a workflow application run on an entire cluster while offering an over 200x speedup factor (normalized by resource) compared to running the actual application, and can achieve, in the limited number of scenarios we study, a prediction accuracy that enables identifying the best storage system configuration

A Quasi-Spherical Gravitational Wave Solution in Kaluza-Klein Theory

An exact solution of the source-free Kaluza-Klein field equations is presented. It is a 5D generalization of the Robinson-Trautman quasi-spherical gravitational wave with a cosmological constant. The properties of the 5D solution are briefly described.Comment: 10 pages Latex, Revtex, submitted to GR

U-duality in three and four dimensions

Using generalised geometry we study the action of U-duality acting in three and four dimensions on the bosonic fields of eleven dimensional supergravity. We compare the U-duality symmetry with the T-duality symmetry of double field theory and see how the $SL(2)\otimes SL(3)$ and SL(5) U-duality groups reduce to the SO(2,2) and SO(3,3) T-duality symmetry groups of the type IIA theory. As examples we dualise M2-branes, both black and extreme. We find that uncharged black M2-branes become charged under U-duality, generalising the Harrison transformation, while extreme M2-branes will become new extreme M2-branes. The resulting tension and charges are quantised appropriately if we use the discrete U-duality group $E_d(Z)$.Comment: v1: 35 pages; v2: minor corrections in section 4.1.2, many references added; v3: further discussion added on the conformal factor of the generalised metric in section 2 and on the Wick-rotation used to construct examples in section

The Potential Clinical and Economic Value of Primary Tumour Identification in Metastatic Cancer of Unknown Primary Tumour: A Population-Based Retrospective Matched Cohort Study.

PurposeSeveral genomic tests have recently been developed to identify the primary tumour in cancer of unknown primary tumour (CUP). However, the value of identifying the primary tumour in clinical practice for CUP patients remains questionable and difficult to prove in randomized trials.ObjectiveWe aimed to assess the clinical and economic value of primary tumour identification in CUP using a retrospective matched cohort study.MethodsWe used the Manitoba Cancer Registry to identify all patients initially diagnosed with metastatic cancer between 2002 and 2011. We defined patients as having CUP if their primary tumour was found 6 months or more after initial diagnosis or never found during the course of disease. Otherwise, we considered patients to have metastatic cancer from a known primary tumour (CKP). We linked all patients with Manitoba Health databases to estimate their direct healthcare costs using a phase-of-care approach. We used the propensity score matching technique to match each CUP patient with a CKP patient on clinicopathologic characteristics. We compared treatment patterns, overall survival (OS) and phase-specific healthcare costs between the two patient groups and assessed association with OS using Cox regression adjustment.ResultsOf 5839 patients diagnosed with metastatic cancer, 395 had CUP (6.8%); 1:1 matching created a matched group of 395 CKP patients. CUP patients were less likely to receive surgery, radiation, hormonal and targeted therapy and more likely to receive cytotoxic empiric chemotherapeutic agents. Having CUP was associated with reduced OS (hazard ratio [HR] 1.31; 95% confidence interval 1.1-1.58), but this lost statistical significance with adjustment for treatment differences. CUP patients had a significant increase in the mean net cost of initial diagnostic workup before diagnosis and a significant reduction in the mean net cost of continuing cancer care.ConclusionIdentifying the primary tumour in CUP patients might enable the use of more effective therapies, improve OS and allow more efficient allocation of healthcare resources

Transition from Knudsen to molecular diffusion in activity of absorbing irregular interfaces

We investigate through molecular dynamics the transition from Knudsen to molecular diffusion transport towards 2d absorbing interfaces with irregular geometry. Our results indicate that the length of the active zone decreases continuously with density from the Knudsen to the molecular diffusion regime. In the limit where molecular diffusion dominates, we find that this length approaches a constant value of the order of the system size, in agreement with theoretical predictions for Laplacian transport in irregular geometries. Finally, we show that all these features can be qualitatively described in terms of a simple random-walk model of the diffusion process.Comment: 4 pages, 4 figure

Modeling Bangladesh's gross domestic product using regression approach

This study finds the factors that affect Bangladesh’s Gross Domestic Product (GDP) through regression approach. Stepwise and Ridge regression techniques have been applied to build the suitable regression model. Model adequacy also has been checked and multicollinearity problem is addressed for a plausible model using appropriate remedial measures for each of the model one after another that yields stepwise regression. The multicollinearity problem has also been tried to combat by ridge regression. Finally, the model which is adequate and free from multicollinearity problem after applying the ridge regression has been considered as the credible model for predicting the GDP of Bangladesh. The final model shows that the factors population, imports of goods and services, agriculture value added, manufacturing value added and labor force are positively affecting the GDP of Bangladesh

Mimicking diffuse supernova antineutrinos with the Sun as a source

Measuring the electron antineutrino component of the cosmic diffuse supernova neutrino background (DSNB) is the next ambitious goal for low-energy neutrino astronomy. The largest flux is expected in the lowest accessible energy bin. However, for E < 15 MeV a possible signal can be mimicked by a solar electron antineutrino flux that originates from the usual 8B neutrinos by spin-flavor oscillations. We show that such an interpretation is possible within the allowed range of neutrino electromagnetic transition moments and solar turbulent field strengths and distributions. Therefore, an unambiguous detection of the DSNB requires a significant number of events at E > 15 MeV.Comment: 4 pages, 1 figur

Are available models reliable for predicting the FRP contribution to the shear resistance of RC beams

In this paper the trustworthiness of the existing theory for predicting the FRP contribution to the shear resistance of reinforced concrete beams is discussed. The most well-known shear models for EBR (External Bonded Reinforcement) are presented, commented on and compared with an extensive experimental database. The database contains the results from more than 200 tests performed in different research institutions across the world. The results of the comparison are not very promising and the use of the additional principle in the actual shear design equations should be questioned. The large scatter between the predicted values of different models and experimental results is of real concern bearing in mind that some of the models are used in present design codes

Hydrodynamic fluctuations in the Kolmogorov flow: Linear regime

The Landau-Lifshitz fluctuating hydrodynamics is used to study the statistical properties of the linearized Kolmogorov flow. The relative simplicity of this flow allows a detailed analysis of the fluctuation spectrum from near equilibrium regime up to the vicinity of the first convective instability threshold. It is shown that in the long time limit the flow behaves as an incompressible fluid, regardless of the value of the Reynolds number. This is not the case for the short time behavior where the incompressibility assumption leads in general to a wrong form of the static correlation functions, except near the instability threshold. The theoretical predictions are confirmed by numerical simulations of the full nonlinear fluctuating hydrodynamic equations.Comment: 20 pages, 4 figure