Damage avoidance design steel beam-column moment connection using high-force-to-volume dissipators

Existing welded steel moment frames are designed to tolerate substantial yielding and plastic rotation under earthquake loads. This sacrificial design approach can lead to permanent, and often irreparable damage when interstory drifts exceed 2%. The experimental seismic performance of a 50% full-scale damage avoidance designed structural steel beam-column connection is presented. The beam-column joint region consists of a top flange-hung beam connected to the column by an angle bracket. High-force-to-volume (HF2V) devices are attached from the column to the beam to provide joint rigidity and energy dissipation as the joint opens and closes. The HF2V devices are connected either below the beam flange or concealed above the beam's lower flange. Reversed cyclic lateral load tests are conducted with drift amplitudes up to 4%. No damage is observed in the principal beam and column structural elements. The need for stiff device connections to achieve optimal device performance is demonstrated, and potential design solutions presented. Stable hysteresis and repeatable energy dissipation for a large number of cycles up to the 4% drift level is observed. It is concluded that superior and repeatable energy dissipation without damage can be achieved for every dynamic motion cycle, in contrast to conventional sacrificially designed welded moment frame connections

PENDUGAAN DATA HILANG PADA RANCANGAN ACAK KELOMPOK LENGKAP DENGAN METODE YATES DAN ALGORITMA EXPECTATION MAXIMIZATION

Dalam sebuah percobaan, seringkali percobaan tidak selamanya berjalan sesuai dengan yang diharapkan. Jika data yang diperoleh dari suatu penelitian hanya sebagian teramati, maka masalah umum dalam percobaan telah terjadi yang dikenal sebagai data hilang. Hal tersebut dapat disebabkan oleh berbagai hal, misalnya perlakuan yang tidak tepat, kerusakan pada obyek percobaan dan data yang tidak logis. Nilai-nilai yang hilang tersebut harus diduga dan diganti sebelum melakukan analisis lebih lanjut. Metode pendugaan data hilang dalam penelitian ini adalah metode Yates dan Algoritma EM. Konsep dasar dalam metode Yates adalah meminimumkan jumlah kuadrat galat, sedangkan konsep dasar Algoritma EM adalah memaksimumkan fungsi likelihood. Pengaplikasian penelitian ini pada Rancangan Acak Kelompok Lengkap (RAKL) dengan besaran perlakuan yang berbeda (3 perlakuan sampai dengan 7 perlakuan) pada 3 kelompok. Pendugaan data hilang dengan metode Algoritma EM lebih baik digunakan dari pada metode Yates jika posisi data hilang secara acak dan dalam satu perlakuan, berbeda halnya jika data hilang dalam satu kelompok lebih baik menggunakan metode Yates dibandingkan metode Algoritma EM. Pendugaan data hilang dengan metode Yates dan algoritma EM menghasilkan nilai dugaan yang sama jika ada 1 data hilang, sehingga sama-sama baik digunakan. Kata Kunci : Rancangan acak kelompok lengkap, data hilang, metode Yates, metode Algoritma E

Improved seismic hazard model with application to probabilistic seismic demand analysis

An improved seismic hazard model for use in performance-based earthquake engineering is presented. The model is an improved approximation from the so-called 'power law' model, which is linear in log-log space. The mathematics of the model and uncertainty incorporation is briefly discussed. Various means of fitting the approximation to hazard data derived from probabilistic seismic hazard analysis are discussed, including the limitations of the model. Based on these 'exact' hazard data for major centres in New Zealand, the parameters for the proposed model are calibrated. To illustrate the significance of the proposed model, a performance-based assessment is conducted on a typical bridge, via probabilistic seismic demand analysis. The new hazard model is compared to the current power law relationship to illustrate its effects on the risk assessment. The propagation of epistemic uncertainty in the seismic hazard is also considered. To allow further use of the model in conceptual calculations, a semi-analytical method is proposed to calculate the demand hazard in closed form. For the case study shown, the resulting semi-analytical closed form solution is shown to be significantly more accurate than the analytical closed-form solution using the power law hazard model, capturing the 'exact' numerical integration solution to within 7% accuracy over the entire range of exceedance rat

Influence of Vertical Ground Motions on the Seismic Fragility Modeling of a Bridge-Soil-Foundation System

This paper explores the effects of vertical ground motions (VGMs) on the component fragility of a coupled bridged-soil-foundation (CBSF) system with liquefaction potential, and highlights the unique considerations on the demand and capacity model required for fragility analysis under VGMs. Optimal intensity measures (IMs) that account for VGMs are identified. Moreover, fragility curves that consider capacity change with fluctuating axial force are derived. Results show that the presence of VGMs has a minor effect on the failure probabilities of piles and expansion bearings, while it has a great influence on fixed bearings. Whether VGMs have an impact on column fragilities depends on the design axial load ratio. Finally, more accurate fragility surfaces are derived, which are compared with results of conventional fragility curves. This study highlights the important role that VGMs play in the selection of optimal IMs, and the capacity and fragility representation of certain components of CBSF systems

Professionalism and person-centredness: developing a practice based approach to leadership within NHS maternity services in the UK

This paper, based on data taken from in-depth interviews with senior midwives and obstetricians and conducted as part of a critical ethnographic study, argues for a greater appreciation of person-centred, value-led midwifery practice. The paper begins with a discussion of the way midwifery practice is shaped by encoded and embodied knowledge. The paper subsequently focuses on an emergent practice based leadership using an adapted Aristotelian conceptual framework derived from MacIntyre (2007). Professional dissonance is highlighted as a difficulty experienced by repositioned managers who are also expected to be leaders in their field. Using data gathered from in-depth interviews it is contended that establishing person-centred care might be better achieved through the development of practice based leadership (rather than solely by adherence to organisational requirements). This type of leadership could potentially nurture a professional environment that promotes qualities, such as agency, commitment and high levels of competence among midwives. Such leadership is central to UK government priorities and is applicable to a global practice development agenda

Evaluation of a brief art psychotherapy group for adults suffering from mild to moderate depression: Pilot pre, post and follow-up study

Current therapies do not offer universal solutions for the ‘global burden’ of depression. By focusing on non-verbal communication and creativity, arts therapies might present a relevant treatment option but their effectiveness remains unclear. A pilot study was undertaken to evaluate a brief art therapy group for adults suffering from depression. Adults experiencing mild to moderate depression took part in art therapy and completed questionnaires at three points in time. The intensity of depression, levels of anxiety and general wellbeing were measured. Semi-structured interviews focused on participants’ expectations and experience of therapy. A decrease in depressive symptoms was observed immediately after the therapy and at the follow-up, and a trend for improvement of subjectively perceived wellbeing was recorded. Potential benefits of therapy recognised by participants included: acceptance of depression, readiness to express emotions, sense of self and awareness of others, readiness for meaningful relationships, sense of achievement, sense of balance and new insights, growth and meaning. The statistically significant results and participants’ experience indicate that art therapy may offer a valuable treatment option for depression, and further research is recommended. Future studies should explore ways of addressing both the outcomes and the process of therapy through creative methodological designs

Idiotypic DNA vaccination for the treatment of multiple myeloma: safety and immunogenicity in a phase I clinical study

We report on the safety and immunogenicity of idiotypic DNA vaccination in a phase I, non-randomised, open-label study in patients with multiple myeloma. The study used DNA fusion gene vaccines encoding patient-specific single chain variable fragment, or idiotype (Id), linked to fragment C (FrC) of tetanus toxin. Patients in complete or partial response following high-dose chemotherapy and autologous stem cell transplant were vaccinated intramuscularly with 1 mg DNA on six occasions, beginning at least 6 months post-transplant; follow-up was to week 52. Fourteen patients were enrolled on study and completed vaccinations. Idiotypic DNA vaccines were well tolerated with vaccine-related adverse events limited to low-grade constitutional symptoms. FrC- and Id-specific T-cell responses were detected by ex vivo ELISPOT in 9/14 and 3/14 patients, respectively. A boost of pre-existing anti-FrC antibody (Ab) was detected by ELISA in 8/14 patients, whilst anti-Id Ab was generated in 1/13 patients. Overall, four patients (29 %) made an immune response to FrC and Id, with six patients (43 %) responding to FrC alone. Over the 52-week study period, serum paraprotein was undetectable, decreased or remained stable for ten patients (71 %), whilst ongoing CR/PR was maintained for 11 patients (79 %). The median time to progression was 38.0 months for 13/14 patients. Overall survival was 64 % after a median follow-up of 85.6 months

A Bayesian adaptive design for biomarker trials with linked treatments.

BACKGROUND: Response to treatments is highly heterogeneous in cancer. Increased availability of biomarkers and targeted treatments has led to the need for trial designs that efficiently test new treatments in biomarker-stratified patient subgroups. METHODS: We propose a novel Bayesian adaptive randomisation (BAR) design for use in multi-arm phase II trials where biomarkers exist that are potentially predictive of a linked treatment's effect. The design is motivated in part by two phase II trials that are currently in development. The design starts by randomising patients to the control treatment or to experimental treatments that the biomarker profile suggests should be active. At interim analyses, data from treated patients are used to update the allocation probabilities. If the linked treatments are effective, the allocation remains high; if ineffective, the allocation changes over the course of the trial to unlinked treatments that are more effective. RESULTS: Our proposed design has high power to detect treatment effects if the pairings of treatment with biomarker are correct, but also performs well when alternative pairings are true. The design is consistently more powerful than parallel-groups stratified trials. CONCLUSIONS: This BAR design is a powerful approach to use when there are pairings of biomarkers with treatments available for testing simultaneously.This work was supported by the Medical Research Council (grant number G0800860) and the NIHR Cambridge Biomedical Research Centre.This is the final version of the article. It first appeared from NPG via http://dx.doi.org/10.1038/bjc.2015.27

Observation of an Excited Bc+ State

Using pp collision data corresponding to an integrated luminosity of 8.5 fb-1 recorded by the LHCb experiment at center-of-mass energies of s=7, 8, and 13 TeV, the observation of an excited Bc+ state in the Bc+π+π- invariant-mass spectrum is reported. The observed peak has a mass of 6841.2±0.6(stat)±0.1(syst)±0.8(Bc+) MeV/c2, where the last uncertainty is due to the limited knowledge of the Bc+ mass. It is consistent with expectations of the Bc∗(2S31)+ state reconstructed without the low-energy photon from the Bc∗(1S31)+→Bc+γ decay following Bc∗(2S31)+→Bc∗(1S31)+π+π-. A second state is seen with a global (local) statistical significance of 2.2σ (3.2σ) and a mass of 6872.1±1.3(stat)±0.1(syst)±0.8(Bc+) MeV/c2, and is consistent with the Bc(2S10)+ state. These mass measurements are the most precise to date