Parametric effects on dryout of propane in a vertical circular mini-channel

This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute.This article presents dryout results of propane in a vertical circular mini channel made of stainless steel with an internal diameter of 1.70 mm and a heated length of 245 mm. The experiments are performed at three saturation temperatures of 23 degrees C, 33 degrees C and 43 degrees C. Mass flux is varied from 100 kg/m2s to 500 kg/m2s.The heat flux is increased in steps up to occurrence of dryout. The effect of different parameters such as mass flux, vapour quality and saturation temperature on the dryout heat flux is investigated. The results show that the dryout heat flux increases with the increase in mass flux and with the decrease of vapour quality. Almost no effect of saturation temperature on the dryout heat flux is observed. The generalised CHF correlations developed for macro and micro scale from the literature are compared with experimental results. Correlations developed by Callizo et al. (2008), Bowring (1972) and Katto and Ohno (1984) gave reasonably good predictions

Experimental investigation of two-phase pressure drop in a microchannel

This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the Italian Union of Thermofluid dynamics, the Process Intensification Network, HEXAG - the Heat Exchange Action Group and the Institute of Mathematics and its Applications.An experimental study of two-phase pressure drop in a horizontal circular microchannel is presented in this paper. Test tube is made of fused silica having an internal diameter of 781μm with a total length of 261mm and a heated length of 191mm.The external surface of the test tube is coated with an electrically conductive thin layer of ITO (Indium Tin Oxide) for direct heating of test section. Refrigerant R134a was used as the working fluid and mass flux during the experiments was varied from 100 to 650 kg/m2sec. Experiments were performed at a system pressure of 7.70 bar (corresponding to saturation temperature of 30oC). Two-phase frictional pressure drop characteristics with different mass flux, vapour fraction and heat flux were explored in detail. Finally, the prediction capability of well known available correlations in the literature, developed for macrochannels and others especially developed for microchannels was also checked. The homogeneous model predicts the data fairly well with a mean absolute deviation (MAD) of 19% and 69% of data within ±20% error band. The Müller-Steinhagen and Heck (1986) correlation developed for macrochannels predicts the data with a MAD of 19% and 61% of data within ±20% error band. The Mishima and Hibiki (1996) correlation, developed for microchannels, also shows fairly good approximation of the data with MAD of 19% and 57% of data within ±20% error band

Cr doped III-V nitrides: potential candidates for spintronics

Studies of Cr-doped III-V nitrides, dilute magnetic alloys, in the zinc-blende crystal structure are presented. The objective of the work is to investigate half-metallicity in Al(0.75)Cr(0.25)N, Ga(0.75)Cr(0.25)N and In(0.75)Cr(0.25)N for their possible application in the spin based electronic devices. The calculated spin polarized band structures, electronic properties and magnetic properties of these compounds reveal that Al0.75Cr0.25N and Ga0.75Cr0.25N are half-metallic dilute magnetic semiconductors while In0.75Cr0.25N is metallic in nature. The present theoretical predictions provide evidence that some Cr doped III-V nitrides can be used in spintronics devices

Synthesis and fluorine-mediated interactions in methanol-encapsulated solid state self-assembly of an isatin-thiazoline hybrid

International audienceAn exciting isatin-thiazoline hybrid molecule 2 having -C=N-N=C- linkage has been synthesized in 88% yield by the reaction of 5-fluoroisatin with N-(4-fluorophenyl)hydrazinecarbothioamide followed by condensation of the resultant isatin-thiosemicarbazone intermediate with p-chlorophenacyl bromide. The solid state self-assembly of this hybrid molecule was studied by X-ray crystallographic technique. A layered assembly composed of 1D-chains with methanol molecules encapsulated between every two chains is obtained, making a bi-chain sandwich like structure. The supramolecular forces involved in the stabilization of this structure are importantly fluorine-mediated interactions (C-H···F, F···S and F···π) along with others i.e. N-H···O, O-H···O, C-H···O, Cl···π, C-H···π and π···π interactions. To the best of our knowledge, this is the first example of solid state fluorine-mediated C-H···F, F···S and F···π interactions found in a family of isatin-based compound

Ab-initio study of the bandgap engineering of Al(1-x)Ga(x)N for optoelectronic applications

A theoretical study of Al(1-x)Ga(x)N, based on full-potential linearized augmented plane wave method, is used to investigate the variations in the bandgap, optical properties and non-linear behavior of the compound with the variation of Ga concentration. It is found that the bandgap decreases with the increase of Ga in Al(1-x)Ga(x)N. A maximum value of 5.5 eV is determined for the bandgap of pure AlN which reaches to minimum value of 3.0 eV when Al is completely replaced by Ga. The static index of refraction and dielectric constant decreases with the increase in bandgap of the material, assigning a high index of refraction to pure GaN when compared to pure AlN. The refractive index drops below 1 for photon energies larger than 14 eV results group velocity of the incident radiation higher than the vacuum velocity of light. This astonishing result shows that at higher energies the optical properties of the material shifts from linear to non-linear. Furthermore, frequency dependent reflectivity and absorption coefficients show that peak value of the absorption coefficient and reflectivity shifts towards lower energy in the UV spectrum with the increase in Ga concentration. This comprehensive theoretical study of the optoelectronic properties of the alloys is presented for the first time which predicts that the material can be effectively used in the optical devices working in the visible and UV spectrum.Comment: 18 pages, 7 figure

Bi-allelic JAM2 Variants Lead to Early-Onset Recessive Primary Familial Brain Calcification.

Primary familial brain calcification (PFBC) is a rare neurodegenerative disorder characterized by a combination of neurological, psychiatric, and cognitive decline associated with calcium deposition on brain imaging. To date, mutations in five genes have been linked to PFBC. However, more than 50% of individuals affected by PFBC have no molecular diagnosis. We report four unrelated families presenting with initial learning difficulties and seizures and later psychiatric symptoms, cerebellar ataxia, extrapyramidal signs, and extensive calcifications on brain imaging. Through a combination of homozygosity mapping and exome sequencing, we mapped this phenotype to chromosome 21q21.3 and identified bi-allelic variants in JAM2. JAM2 encodes for the junctional-adhesion-molecule-2, a key tight-junction protein in blood-brain-barrier permeability. We show that JAM2 variants lead to reduction of JAM2 mRNA expression and absence of JAM2 protein in patient's fibroblasts, consistent with a loss-of-function mechanism. We show that the human phenotype is replicated in the jam2 complete knockout mouse (jam2 KO). Furthermore, neuropathology of jam2 KO mouse showed prominent vacuolation in the cerebral cortex, thalamus, and cerebellum and particularly widespread vacuolation in the midbrain with reactive astrogliosis and neuronal density reduction. The regions of the human brain affected on neuroimaging are similar to the affected brain areas in the myorg PFBC null mouse. Along with JAM3 and OCLN, JAM2 is the third tight-junction gene in which bi-allelic variants are associated with brain calcification, suggesting that defective cell-to-cell adhesion and dysfunction of the movement of solutes through the paracellular spaces in the neurovascular unit is a key mechanism in CNS calcification

Zero-Shot Generalizable End-to-End Task-Oriented Dialog System using Context Summarization and Domain Schema

Task-oriented dialog systems empower users to accomplish their goals by facilitating intuitive and expressive natural language interactions. State-of-the-art approaches in task-oriented dialog systems formulate the problem as a conditional sequence generation task and fine-tune pre-trained causal language models in the supervised setting. This requires labeled training data for each new domain or task, and acquiring such data is prohibitively laborious and expensive, thus making it a bottleneck for scaling systems to a wide range of domains. To overcome this challenge, we introduce a novel Zero-Shot generalizable end-to-end Task-oriented Dialog system, ZS-ToD, that leverages domain schemas to allow for robust generalization to unseen domains and exploits effective summarization of the dialog history. We employ GPT-2 as a backbone model and introduce a two-step training process where the goal of the first step is to learn the general structure of the dialog data and the second step optimizes the response generation as well as intermediate outputs, such as dialog state and system actions. As opposed to state-of-the-art systems that are trained to fulfill certain intents in the given domains and memorize task-specific conversational patterns, ZS-ToD learns generic task-completion skills by comprehending domain semantics via domain schemas and generalizing to unseen domains seamlessly. We conduct an extensive experimental evaluation on SGD and SGD-X datasets that span up to 20 unique domains and ZS-ToD outperforms state-of-the-art systems on key metrics, with an improvement of +17% on joint goal accuracy and +5 on inform. Additionally, we present a detailed ablation study to demonstrate the effectiveness of the proposed components and training mechanis

Cytotoxicity, In vitro anti-Leishmanial and fingerprint HPLC- photodiode array analysis of the roots of Trillium govanianum.

Trillium govanianum Wall. ex D. Don (Melanthiaceae alt. Trilliaceae), commonly known as 'nagchhatry' or 'teen patra', distributed from Pakistan to Bhutan about 2500-3800 m altitude is indigenous to Himalayas region. In folk medicine the plant has been reported for the treatment of wound healing, sepsis and in various sexual disorders. This paper reports, for the first time, to evaluate the cytotoxicity, in vitro anti-leishmanial (promastigotes) and fingerprint HPLC-photodiode array analysis of the MeOH extract of the roots of T. govanianum and its solid phase extraction fractions. Reverse phase HPLC-PDA based quantification revealed the presence of significant amount of quercetin, myrecetin and kaemferol ranging from 0.221to 0.528 μg/mg DW. MeOH extract revealed distinguishable protein kinase inhibitory activity against Streptomyces 85E strain with 18 mm bald phenotype. The remarkable toxicity profile against brine shrimps and leishmanial was manifested by MeOH extract with LC50 10 and 38.5 μg/mL, respectively