Choosing the right microcontroller: A comparison of 8-bit Atmel, Microchip and Freescale MCUs

When choosing a microcontroller there are many options, so which platform should you choose? There is little independent information available to help engineers decide which platform might best suit their needs and most designers tend to stick with the brand with which they are familiar. This is a difficult question to answer without bias if the people conducting the evaluations have had previous experience with MCU programming predominantly on one platform. This article draws on a case study. We built three “Smart” Sprinkler Taps, small, self-contained irrigation controllers, differing only in the microcontroller unit (MCU) on the inside. We compare cost, development software quality and hardware performance from the perspective of a new user to each of the platforms

Integrating Food Policy with Growing Health and Wellness Concerns: An Analytical Literature Review of the Issues Affecting Government, Industry, and Civil Society

Over the past few years, there has been growing global interest in the link between food and health. This paper provides a review of some of the recent literature describing these linkages. The first section provides an overview of findings that link the consumption of fruits and vegetables, meat, eggs, whole-grains, alcohol, sugar, dairy, fish, pulses, soy, and nuts to coronary heart disease, cancer, stroke, and diabetes. The authors then summarize various international and domestic non-government organizations' views about these issues. The third section centres on the food industry and its responses to growing health concerns. The fourth section is an overview of public policy relating to food and health, including the use of food policy to change consumption behaviour and address obesity. This section also includes a discussion of the relevance of policies designed to discourage smoking to the current debate on obesity. The Conclusion highlights ways in which Canadian food policy can be adapted in order to better promote health and wellness.Food Consumption/Nutrition/Food Safety, Health Economics and Policy, Agribusiness,

Defective phagocytic corpse processing results in neurodegeneration and can be rescued by TORC1 activation

This work was supported by NIH Grants R01 GM094452 (K.M.) and F31 GM099425 (J.I.E.), BU Alzheimer's Disease Core Center NIH Grant P30 AG13846, Boston University Undergraduate Research Opportunities Program grants (J.A.T., V.S.), and NIH Grant R01 AG044113 to M.B.F. We thank the Bloomington Stock Center, TRiP at Harvard Medical School, the Kyoto Drosophila Genetic Resource Center, Estee Kurant, Eric Baehrecke, Marc Freeman, and Mary Logan for fly strains. We thank Todd Blute for assistance with electron microscopy and the Developmental Studies Hybridoma Bank for antibodies. (R01 GM094452 - NIH; F31 GM099425 - NIH; R01 AG044113 - NIH; P30 AG13846 - BU Alzheimer's Disease Core Center NIH Grant; Boston University Undergraduate Research Opportunities Program)https://www.jneurosci.org/content/36/11/3170.longPublished versionPublished versio

Population Density and Home Range Estimates of Black Rat (Rattus rattus) Populations in Southwestern Puerto Rico

Black rats are among the world’s most invasive rodent species and are responsible for considerable agricultural losses and risks to human health through zoonotic disease. In Puerto Rico, rats may also compete with the primary rabies reservoir (the small Indian mongoose) for baits during oral rabies vaccination (ORV) programs. We evaluated black rat population density and home range size on the Cabo Rojo National Wildlife Refuge, southwestern Puerto Rico. We fitted 10 rats with VHF transmitters and tracked them using radio telemetry for approximately 4 weeks. We entered locations into ArcGIS and obtained minimum convex polygon (MCP) home range estimates. We established two plots of 55 snap traps and performed removal for 5 consecutive days during January and July, to correspond roughly with wet and dry seasons for this region. To calculate abundance, we entered snap trap data using a removal model approach in Program MARK. We calculated the effective trapping area by creating a buffer around the trapping area based on the square root of mean home range estimate. We divided the abundance calculated in MARK by the effective trapping area to calculate the estimated population density. Mean MCP home range estimate was 0.28 ha (SE: 0.05, range: 0.07-0.50 ha). Population density estimates were 114.7 (SE: 201.80) and 19.3 (SE: 6.85) per ha for January and July, respectively. To reduce the potential for rat consumption of ORV baits, wildlife managers should consider conducting ORV activities in Puerto Rico during periods of lower rat abundance or density

Comparative systems of assessment of illness or disability for the purposes of adult social welfare payments. Second report (Carers)

Purpose of the report: This is the second report of the study of comparative systems of assessment of illness or disability for the purposes of adult social welfare payments. This report considers assessment systems for carer payments in relation to disability status of an adult cared-for person. The purpose of the research, as set out in the RFT,is to examine systems for medical/disability assessment and review used in other comparable jurisdictions and to draw key learning for the Irish system.Methodology: The research looks at assessment systems for adult carers payments in a number of OECD countries, using 1) a review of relevant literature (including review of various online academic databases and legal databases) 2) access to online information from social security authorities and others 3) review of detailed evaluations of assessment systems (where these are available) 4)contacts with key informants in the chosen countries. The researchers first carried out a rapid review of assessment systems in a range of OECD countries (see Initial Review). On the basis of this study it was agreed to focus the research on Australia, Netherlands, New Zealand, Nova Scotia (Canada) and the United Kingdom (UK).Structure of the report: In chapter 2, we provide a short overview of issues concerning support for carers drawing on the available literature. Chapter 3 provides an overview of the assessment systems in the five jurisdictions. Finally chapter 4 discusses the relevance of the findings to the Irish system.The detailed country reports are set out in the Annexes

Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington’s disease model

A polyglutamine expansion in the huntingtin (HTT) gene causes neurodegeneration in Huntington’s disease (HD), but the in vivo function of the native protein (Htt) is largely unknown. Numerous biochemical and in vitro studies have suggested a role for Htt in neuronal development, synaptic function and axonal trafficking. To test these models, we generated a null mutant in the putative Drosophila HTT homolog (htt, hereafter referred to asdhtt) and, surprisingly, found that dhtt mutant animals are viable with no obvious developmental defects. Instead, dhtt is required for maintaining the mobility and long-term survival of adult animals, and for modulating axonal terminal complexity in the adult brain. Furthermore, removing endogenous dhtt significantly accelerates the neurodegenerative phenotype associated with a Drosophila model of polyglutamine Htt toxicity (HD-Q93), providing in vivo evidence that disrupting the normal function of Htt might contribute to HD pathogenesis

Brain-Computer Interfaces, Virtual Reality, and Videogames

Major challenges must be tackled for brain-computer interfaces to mature into an established communications medium for VR applications, which will range from basic neuroscience studies to developing optimal peripherals and mental gamepads and more efficient brain-signal processing techniques

Tau promotes neurodegeneration through global chromatin relaxation

The microtubule-associated protein tau is involved in a number of neurodegenerative disorders, including Alzheimer’s disease (AD). Previous studies link oxidative stress and subsequent DNA damage to neuronal death in AD and related tauopathies. Since DNA damage can significantly alter chromatin structure, we examined epigenetic changes in tau-induced neurodegeneration. We have found widespread loss of heterochromatin in tau transgenic Drosophila and mice, and in human AD. Importantly, genetic rescue of tau-induced heterochromatin loss substantially reduced neurodegeneration in Drosophila. We identified oxidative stress and subsequent DNA damage as a mechanistic link between transgenic tau expression and heterochromatin relaxation, and found that heterochromatin loss permits aberrant gene expression in tauopathies. Furthermore, large-scale analyses from human AD brains revealed a widespread transcriptional increase in genes that are heterochromatically silenced in controls. Our results establish heterochromatin loss as a toxic effector of tau-induced neurodegeneration, and identify chromatin structure as a potential therapeutic target in AD

Proxemics with multiple dynamic characters in an immersive virtual environment

An experiment was carried out to examine the impact on electrodermal activity of people when approached by groups of one or four virtual characters at varying distances. It was premised on the basis of proxemics theory that the closer the approach of the virtual characters to the participant, the greater the level of physiological arousal. Physiological arousal was measured by the number of skin conductance responses within a short time period after the approach, and the maximum change in skin conductance level 5 s after the approach. The virtual characters were each either female or a cylinder of human size, and one or four characters approached each subject a total of 12 times. Twelve male subjects were recruited for the experiment. The results suggest that the number of skin conductance responses after the approach and the change in skin conductance level increased the closer the virtual characters approached toward the participants. Moreover, these response variables were inversely correlated with the number of visits, showing a typical adaptation effect. There was some evidence to suggest that the number of characters who simultaneously approached (one or four) was positively associated with the responses. Surprisingly there was no evidence of a difference in response between the humanoid characters and cylinders on the basis of this physiological data. It is suggested that the similarity in this quantitative arousal response to virtual characters and virtual objects might mask a profound difference in qualitative response, an interpretation supported by questionnaire and interview results. Overall the experiment supported the premise that people exhibit heightened physiological arousal the closer they are approached by virtual characters