EPIDEMIOLOGICAL CHARACTERISTICS OF VIRAL HEPATITIS IN PATIENTS WITH RHEUMATIC DISEASES - IMPLICATIONS FROM TREASURE DATABASE

EULAR European Congress of Rheumatology (EULAR) -- JUN 01-04, 2022 -- Copenhagen, DENMARK[Abstract Not Available]European Alliance Assoc Rheumato

PARADOXICAL REACTIONS, ESPECIALLY PSORIASIS IN RHEUMATOLOGY PATIENTS RECEIVING BIOLOGIC THERAPY FROM THE TREASURE DATABASE: A 5-YEAR FOLLOW-UP STUDY

EULAR European Congress of Rheumatology (EULAR) -- JUN 01-04, 2022 -- Copenhagen, DENMARK[Abstract Not Available]European Alliance Assoc Rheumato

BIOLOGIC DRUG PREFERENCES OF TURKISH RHEUMATOLOGISTS IN SPONDILOARTROPATHY PATIENTS WITH ADVANCED CHRONIC RENAL DISEASE

[Abstract Not Available

THE DIFFERENCES BETWEEN THE FIRST PREFERRED BIOLOGICAL DMARD AND THE DRUG SURVIVAL IN GERIATRIC AND YOUNGER ADULT POPULATION WITH RHEUMATOID ARTHRITIS AND PSORIATIC ARTHRITIS: TREASURE REAL-LIFE DATA

EULAR European Congress of Rheumatology (EULAR) -- JUN 01-04, 2022 -- Copenhagen, DENMARK[Abstract Not Available]European Alliance Assoc Rheumato

Angiogenic Peptide Nanofibers Improve Wound Healing in STZ-Induced Diabetic Rats

Low expressions of angiogenic growth factors delay the healing of diabetic wounds by interfering with the process of blood vessel formation. Heparin mimetic peptide nanofibers can bind to and enhance production and activity of major angiogenic growth factors, including VEGF. In this study, we showed that heparin mimetic peptide nanofibers can serve as angiogenic scaffolds that allow slow release of growth factors and protect them from degradation, providing a new therapeutic way to accelerate healing of diabetic wounds. We treated wounds in STZ-induced diabetic rats with heparin mimetic peptide nanofibers and studied repair of full-thickness diabetic skin wounds. Wound recovery was quantified by analyses of re-epithelialization, granulation tissue formation and blood vessel density, as well as VEGF and inflammatory response measurements. Wound closure and granulation tissue formation were found to be significantly accelerated in heparin mimetic gel treated groups. In addition, blood vessel counts and the expressions of alpha smooth muscle actin and VEGF were significantly higher in bioactive gel treated animals. These results strongly suggest that angiogenic heparin mimetic nanofiber therapy can be used to support the impaired healing process in diabetic wounds. © 2016 American Chemical Society

Introduction: Ambidextrous open innovation in the 4th Industrial Revolution

With the popularity of artificial intelligence, big data and Internet of Things, business nowadays is featured with technology advancement, open innovation and collaboration. This happens particularly in the manufacturing sectors, known as the Industrial 4.0 or the 4th Industrial Revolution. Alongside this trend, there is also a movement towards servitisation and service innovation. In the financial service sector, FinTech firms, traditional large firms, intermediaries, users and regulators are actively engaged together to develop a smart system of banking, investing and insurance service. Nevertheless, the sector is facing challenges in relation to security, trust and external disruptions. To solve this, first, this article builds an ambidextrous open innovation model with multi-dimensions, which are motivated by the arriving of the 4th Industrial Revolution. Second, this article applies the ambidextrous open innovation model with multi-dimensions to the financial sectors to validate the model basically. Third, this model is applied to several research studies to obtain additional validation of it

Distribution pattern of psoriasis, anxiety and depression as possible causes of sexual dysfunction in patients with moderate to severe psoriasis

BACKGROUND: Psoriasis may significantly impair sexual function. Depression and organic factors appear to play a key role in this relation. However, beyond genital psoriasis, the importance of the disease's distribution patterns has not been considered. OBJECTIVES: To research sexual function in psoriasis patients and investigate the roles of anxiety, depression and psoriasis' distribution patterns in sexual dysfunction. METHODS: A comparative study matched for sex and age was performed. Eighty patients with moderate to severe psoriasis and 80 healthy controls were included. The participants completed the Massachusetts General Hospital-Sexual Functioning Questionnaire, the Hospital Anxiety and Depression Scale, and the Self-Administered Psoriasis Area and Severity Index. RESULTS: Psoriasis was associated with sexual dysfunction, odds ratio=5.5 (CI 95% 2.6-11.3; p<0.001). Certain distribution patterns of psoriasis, involving specific body regions, were associated with an increase in sexual dysfunction in the group presenting the disease, odds ratio 7.9 (CI 95% 2.3-33.4; p<0.001). Multivariate logistic regression analysis identified anxiety and depression, and the involvement of these specific areas, as possible independent risk factors for sexual dysfunction in patients with moderate to severe psoriasis. CONCLUSION: This study identifies body areas potentially related to sexual dysfunction, independently of anxiety and depression, in psoriasis patients. The results suggest that the assessment of sexual dysfunction and the involvement of these body areas should be considered as disease severity criteria when choosing the treatment for psoriasis patients

Envisioning future innovative experimental ecosystems through the foresight approach. Case: Design Factory

Change makers are visionaries who wish to bring change to their respective fields. As technological change is accelerating, it is relevant to consider, how the way and what we teach can evolve with the future to remain meaningful and pioneering. Design Factory at Aalto University, as an innovative experimental ecosystem with interdisciplinary principles and new teaching methodologies has been successful in and at the forefront in educating the students to be change-makers. The paper presents a case study of holistically anticipating plausible futures for innovative experimental ecosystems utilizing a foresight approach. We analyze how the ways of working, spaces, and teaching methods of one such ecosystem, Design Factory at Aalto University in Finland, could support students learning in the year 20 x 6 {x = 2, 3}. We present the process of drawing virtual lines that connect trends, future drivers, visions, and scenarios using a contemporary approach that fuses qualitative and quantitative methods. The results from the study are six future scenarios for the Design Factory, that have implications for innovation ecosystems in general. These results are expected to further foster or trigger new research and development experiments, directions for building radical environments, new teaching methods and ways of working.Peer reviewe

Size-dependent nonlinear secondary resonance of micro-/nano-beams made of nano-porous biomaterials including truncated cube cells

Porous biomaterials have been utilized in cellular structures in order to mimic the function of bone as a branch of tissue engineering approach. With the aid of nanoporous biomaterials in which the pore size is at nanoscale, the capability of biological molecular isolation becomes more efficient. In the present study, firstly the mechanical properties of nanoporous biomaterials are estimated on the basis of a truncated cube cell model including a refined hyperbolic shear deformation for the associated lattice structure. After that, based upon a nonlocal strain gradient beam model, the size-dependent nonlinear secondary resonance of micro/nano-beams made of the nanoporous biomaterial is predicted corresponding to the both of subharmonic and superharmonic excitations. The non-classical governing differential equation of motion is constructed via Hamilton's principle. By employing the Galerkin technique together with the multiple time-scales method, the nonlocal strain gradient frequency-response and amplitude-response of the nonlinear oscillation of micro/nano-beams made of a nanoporous biomaterial under hard excitation are achieved. It is shown that in the superharmonic case, increasing the pore size leads to enhance the nonlinear hardening spring-type behavior of jump phenomenon and the height of limit point bifurcations. In the subharmonic case, higher pore size causes to increase the gap between two branches associated with the high-frequency and low-frequency solutions