The 2mrad horizontal crossing angle IR layout for a TeV ILC

The current status of the 2mrad crossing angle layout for the ILC is reviewed. The scheme developed in the UK and France is described and the performance discussed for a TeV machine. Secondly, the scheme developed at SLAC and BNL is then studied and modified for a TeV machine. We find that both schemes can handle the higher energy beam with modifications, and share many common features.Comment: The proceedings of the 2005 International Linear Collider Workshop, March 2005. 4 pages, 5 figure

An Injector for the CLIC Test Facility (CTF3)

The CLIC Test Facility (CTF3) is an intermediate step to demonstrate the technical feasibility of the key concepts of the new RF power source for CLIC. CTF3 will use electron beams with an energy range adjustable from 170 MeV (3.5 A) to 380 MeV (with low current). The injector is based on a thermionic gun followed by a classical bunching system embedded in a long solenoidal field. As an alternative, an RF photo-injector is also being studied. The beam dynamics studies on how to reach the stringent beam parameters at the exit of the injector are presented. Simulations performed with the EGUN code showed that a current of 7 A can be obtained with an emittance less than 10 mm.mrad at the gun exit. PARMELA results are presented and compared to the requested beam performance at the injector exit. Sub-Harmonic Bunchers (SHB) are foreseen, to switch the phase of the bunch trains by 180 degrees from even to odd RF buckets. Specific issues of the thermionic gun and of the SHB with fast phase switch are discussed

Modelling fish habitat preference with a genetic algorithm-optimized Takagi-Sugeno model based on pairwise comparisons

Species-environment relationships are used for evaluating the current status of target species and the potential impact of natural or anthropogenic changes of their habitat. Recent researches reported that the results are strongly affected by the quality of a data set used. The present study attempted to apply pairwise comparisons to modelling fish habitat preference with Takagi-Sugeno-type fuzzy habitat preference models (FHPMs) optimized by a genetic algorithm (GA). The model was compared with the result obtained from the FHPM optimized based on mean squared error (MSE). Three independent data sets were used for training and testing of these models. The FHPMs based on pairwise comparison produced variable habitat preference curves from 20 different initial conditions in the GA. This could be partially ascribed to the optimization process and the regulations assigned. This case study demonstrates applicability and limitations of pairwise comparison-based optimization in an FHPM. Future research should focus on a more flexible learning process to make a good use of the advantages of pairwise comparisons

PHIL: a Test Beam line at LAL

WEPP078International audienceIn the framework of a European contract*, LAL is in charge of the construction of one photo-injector for the drive beam linac of the CLIC Test Facility 3 [1] at CERN. This contract together with national funds allowed LAL to build a home test accelerator, PHIL, with the same photo-injector as for CTF3. The goal is to undergo experiments on the design and technology of advanced RF guns, to develop diagnostics and feedback techniques, a part of the beam time will be also shared with users of the electron beam. So far, the construction of this accelerator at LAL was very much delayed because of the legal obligation to upgrade the radiation shielding in agreement with the actual radiation safety thresholds. The required civil engineering is now finished and the installation of the components is under way. We will first present a design of the accelerator and few dynamic simulation results. Finally we will give an up to date status of the accelerator construction

A laser triggered electron source for pulsed radiolysis

We present the design of a photo-injector based accelerator for pulsed radiolysis applications. This machine is destined to meet the needs of the physical chemistry community at the Universite de Paris XI. A 4 MeV Energy electron pulse of a few picoseconds duration and with a charge in the range of 1 to 10 nC is produced from a Cs/sub 2 /Te photocathode. The photocathode is placed in the half energy spread cell of a 1-1/2 cell, 3 GHz RF gun, whose design is based on the gun used for the drive beam of the CERN CLIC Test facility. A 4 cell "booster" cavity is then used to accelerate the beam to an energy of 9 MeV. The transport system consists of a quadrupole triplet downsteam of the booster, two rectangular, 30 degree bend, dipoles with a pair of quadrupoles between them and a second triplet downstream of the second dipole. Energy dependent path length effects in the two dipoles allow the possibility of magnetic bunch compression depending on the phase-energy correlation of the bunch exiting the booster cavity. The beam envelope and the bunch length have been calculated through the transport line using TRACE-3d and PARMELA. These codes allow us to verify the required beam parameters at the experimental areas. We discuss the adjustment of the optics, aimed at producing the minimum electron bunch length at the experimental targets. (4 refs)

Cost and Financial Management 2A

Exam paper for second semester: Cost and Financial Management 2

A Compact Ring for Thom X-Ray Source

International audienceThe goal of X-ray sources based on Compton back scattering processes is to develop a compact device, which could produce an intense flux of monochromatic X-rays. Compton back-scattering resuls from collisions between laser pulses and relativistic electron bunches. Due to the relative low value of the Compton cross section, a high charge electron beam, a low emittance and a high focusing at the interaction point are required for the electron beam. In addition, the X-ray flux is related to the characteristics of the electron beam, which are themselves dynamically affected by the Compton interaction. One possible configuration is to inject frequently into a storage ring with a low emittance linear accelerator without waiting for the synchrotron equilibrium. As a consequence, the optics should be designed taking into account the characteristics of the electron beam from the linear accelerator. The accelerator ring design for a 50 MeV electron beam, aiming at producing a flux higher than 1013 ph/s, will be presented

Social Network, Surgeon, and Media Influence on the Decision to Undergo Contralateral Prophylactic Mastectomy

OBJECTIVES: The rate of contralateral prophylactic mastectomy (CPM) has risen sharply in the past decade. The current study was designed to examine social network, surgeon, and media influence on patients' CPM decision-making, examining not only who influenced the decision, and to what extent, but also the type of influence exerted. METHODS: Patients (N=113) who underwent CPM at 4 Indiana University-affiliated hospitals between 2008 and 2012 completed structured telephone interviews in 2013. Questions addressed the involvement and influence of the social network (family, friends, and nonsurgeon health professionals), surgeon, and media on the CPM decision. RESULTS: Spouses, children, family, friends, and health professionals were reported as exerting a meaningful degree of influence on patients' decisions, largely in ways that were positive or neutral toward CPM. Most surgeons were regarded as providing options rather than encouraging or discouraging CPM. Media influence was present, but limited. CONCLUSIONS: Patients who choose CPM do so with influence and support from members of their social networks. Reversing the increasing choice of CPM will require educating these influential others, which can be accomplished by encouraging patients to include them in clinical consultations, and by providing patients with educational materials that can be shared with their social networks. Surgeons need to be perceived as having an opinion, specifically that CPM should be reserved for those patients for whom it is medically indicated

Anti-plasmodial polyvalent interactions in Artemisia annua L. aqueous extract – possible synergistic and resistance mechanisms

Artemisia annua hot water infusion (tea) has been used in in vitro experiments against P. falciparum malaria parasites to test potency relative to equivalent pure artemisinin. High performance liquid chromatography (HPLC) and mass spectrometric analyses were employed to determine the metabolite profile of tea including the concentrations of artemisinin (47.5±0.8 mg L-1), dihydroartemisinic acid (70.0±0.3 mg L-1), arteannuin B (1.3±0.0 mg L-1), isovitexin (105.0±7.2 mg L-1) and a range of polyphenolic acids. The tea extract, purified compounds from the extract, and the combination of artemisinin with the purified compounds were tested against chloroquine sensitive and chloroquine resistant strains of P. falciparum using the DNA-intercalative SYBR Green I assay. The results of these in vitro tests and of isobologram analyses of combination effects showed mild to strong antagonistic interactions between artemisinin and the compounds (9-epi-artemisinin and artemisitene) extracted from A. annua with significant (IC50 <1 μM) anti-plasmodial activities for the combination range evaluated. Mono-caffeoylquinic acids, tri-caffeoylquinic acid, artemisinic acid and arteannuin B showed additive interaction while rosmarinic acid showed synergistic interaction with artemisinin in the chloroquine sensitive strain at a combination ratio of 1:3 (artemisinin to purified compound). In the chloroquine resistant parasite, using the same ratio, these compounds strongly antagonised artemisinin anti-plasmodial activity with the exception of arteannuin B, which was synergistic. This result would suggest a mechanism targeting parasite resistance defenses for arteannuin B’s potentiation of artemisinin

One-dimensional spectral analysis techniques for multilevel PWM strategies

This paper presents a novel spectral analysis technique for multilevel modulation. Conventionally, such analyses use a double Fourier series technique, but this approach can become intractable when complex reference waveforms (e.g., multilevel space vector offsets) and regular sampling processes are considered. In contrast, the strategy proposed in this paper separates the multilevel pulse width modulation (PWM) waveform into a spectral image of the reference, and sideband basis functions which are then expanded using a one-dimensional Fourier series. The coefficients of this Fourier series are defined by a one-dimensional Fourier integral that is simpler in form compared to the corresponding double integral associated with the double Fourier series. This analysis technique naturally incorporates regular sampling, and a discrete formulation is developed that enables complex PWM reference waveforms, including centered space vector offsets, to be solved. Results of this analysis are validated against previously published multilevel inverter double Fourier series results and matching switched simulations