29,326 research outputs found

    The History of the Development of Narcotics

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    Design of a second life product family from the perspective of the remanufacturing agent

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    This thesis presents a method of solving a newly posed Second Life Product Family Design problem. This is unique in that the architecture of the product is not speci ed to be identical to one of the recaptured products, rather it is determined through optimization. The problem is framed using Conjoint Analysis and the Multi Nomial Logit Model, formatted with respect to components available for inclusion in the nal products and then solved using an implementation of Genetic Algorithms. The solution method is also encapsulated in a software module which can be disseminated to industrial users without a background in optimization or familiarity with Genetic Algorithms. A case study is performed to determine the e ectiveness of the proposed solution method, and analyze the in uences di erent market conditions and component similarities can have on the optimal design. It is concluded that the proposed method converges to an optimal Second Life Product Family Design

    Can children with speech difficulties process an unfamiliar accent?

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    This study explores the hypothesis that children identified as having phonological processing problems may have particular difficulty in processing a different accent. Children with speech difficulties (n = 18) were compared with matched controls on four measures of auditory processing. First, an accent auditory lexical decision task was administered. In one condition, the children made lexical decisions about stimuli presented in their own accent (London). In the second condition, the stimuli were spoken in an unfamiliar accent (Glaswegian). The results showed that the children with speech difficulties had a specific deficit on the unfamiliar accent. Performance on the other auditory discrimination tasks revealed additional deficits at lower levels of input processing. The wider clinical implications of the findings are considered

    Desirable Host Plant Qualities in Wild Rice \u3ci\u3e(Zizania Palustris)\u3c/i\u3e for Infestation by the Rice Worm \u3ci\u3eApamea Apamiformis\u3c/i\u3e (Lepidoptera: Noctuidae)

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    The rate at which an insect infests hosts by ovipositioning and/or subsequent growth of larvae often depends on specific desirable host plant qualities. In this study, we measured the infestation rate of wild rice, Zizania palustris, by the wild rice worm, Apamea apamiformis, D. F. Hardwick (Lepidoptera: Noctuidae) and compared it to sediment nitrogen availability, plant biomass, plant density, litter accumulation, and seed carbohydrate and nitrogen concentration. Plant density and litter accumulation had no effect on infestation rates. Infestation rate increased with plant biomass and sediment nitrogen availability. The correlation between infestation rate and sediment nitrogen availability seems to reflect the fact that high nitrogen availability produces larger plants rather than more nutritious seeds as the infestation rate was not correlated with seed glucose content and surprisingly decreased with concentration of nitrogen in seeds. Infestation rate was not related to any other measured quantities. Therefore, Apamea appear to infest larger, rapidly growing host plants which are made possible by high sediment nitrogen availability

    The Feeding Zones of Terrestrial Planets and Insights into Moon Formation

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    [Abridged] We present an extensive suite of terrestrial planet formation simulations that allows quantitative analysis of the stochastic late stages of planet formation. We quantify the feeding zone width, Delta a, as the mass-weighted standard deviation of the initial semi-major axes of the planetary embryos and planetesimals that make up the final planet. The size of a planet's feeding zone in our simulations does not correlate with its final mass or semi-major axis, suggesting there is no systematic trend between a planet's mass and its volatile inventory. Instead, we find that the feeding zone of any planet more massive than 0.1M_Earth is roughly proportional to the radial extent of the initial disk from which it formed: Delta a~0.25(a_max-a_min), where a_min and a_max are the inner and outer edge of the initial planetesimal disk. These wide stochastic feeding zones have significant consequences for the origin of the Moon, since the canonical scenario predicts the Moon should be primarily composed of material from Earth's last major impactor (Theia), yet its isotopic composition is indistinguishable from Earth. In particular, we find that the feeding zones of Theia analogs are significantly more stochastic than the planetary analogs. Depending on our assumed initial distribution of oxygen isotopes within the planetesimal disk, we find a ~5% or less probability that the Earth and Theia will form with an isotopic difference equal to or smaller than the Earth and Moon's. In fact we predict that every planetary mass body should be expected to have a unique isotopic signature. In addition, we find paucities of massive Theia analogs and high velocity moon-forming collisions, two recently proposed explanations for the Moon's isotopic composition. Our work suggests that there is still no scenario for the Moon's origin that explains its isotopic composition with a high probability event.Comment: 16 pages, 22 figures, accepted for publication in Icarus; fixed typo

    Beyond Gift and Bargain: Some Suggestions for Increasing Kidney Exchanges

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    Each year, thousands of people in the United States die from end stage renal disease (ESRD), despite the fact that we have the medical knowledge necessary to save them. The reason is simple: these people need a kidney transplant and we have too few kidneys. Given our current technology, the only way to meet the massive annual shortfall between the number of kidneys that are donated and the number of kidneys that are necessary to save the lives of those with ESRD is to increase the number of living donations. The debate on how to do so has often pitted those who favor creating a “free market” in human organs against those who believe that the selling of organs by human donors poses unacceptable evils and risks. Current law prohibits donors from being paid for kidneys. Once the donation has been made, however, the kidney will often change hands in exchange for money several times before reaching the patient. There are no serious proposals to ban such transactions. This article generally sympathizes with those who favor the free alienation of kidneys by donors in exchange for payment. The goal of this article, however, is not to make another charge across the no man’s land separating free-marketeers from prohibitionists. Rather, it aims to explore ways in which we can increase trust in order to foster a promising new development in transplant medicine: extended kidney exchange
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