Theory of tunneling spectroscopy of normal metal/ferromagnet/spin-triplet superconductor junctions

We study the tunneling conductance of a ballistic normal metal / ferromagnet / spin-triplet superconductor junction using the extended Blonder-Tinkham-Klapwijk formalism as a model for a $c$-axis oriented Au / SrRuO$_{3}$ / Sr$_{2}$RuO$_{4}$ junction. We compare chiral $p$-wave (CPW) and helical $p$-wave (HPW) pair potentials, combined with ferromagnet magnetization directions parallel and perpendicular to the interface. For fixed $\theta_{M}$, where $\theta_{M}$ is a direction of magnetization in the ferromagnet measured from the $c$-axis, the tunneling conductance of CPW and HPW clearly show different voltage dependencies. It is found that the cases where the $d$-vector is perpendicular to the magnetization direction (CPW with $\theta_{M} = \pi/2$ and HPW with $\theta_{M} = 0$) are identical. The obtained results serve as a guide to determine the pairing symmetry of the spin-triplet superconductor Sr$_{2}$RuO$_{4}$.Comment: 12 pages, 7 figures. There is also a supplementary (not uploaded

Aggressions, social cognitions, anger and sadness in bullies and victims

Background: The present study aimed to investigate children's social information processing (SIP) and emotions in the bullying situation, taking into account reactive and proactive aggression. More specifically, we investigated the way in which children interpret social information, which goals they select, how they evaluate their responses and which emotions they express in hypothetical situations. Method: The participants comprised 242 Dutch children (120 girls and 122 boys; mean age: 117.2 months), who were assigned by means of peer nominations (Salmivalli, Lagerspetz, et al., 1996) to one of the following roles: bully (n = 21), follower of the bully (n = 38), victim (n = 35), defender of the victim (n = 48), outsider (n = 52) and not involved (n = 32). Sixteen children (including 3 bully/victims) were not given any role. The reactive and proactive aggression scale (Dodge, & Coie, 1987) was filled out by teachers in order to test the association between these types of aggression and involvement in bullying. Children were presented with ambiguous scenarios and responded to questions about attribution of intent, goal selection and emotions (anger and sadness). In addition, two questionnaires were administered to children: one assessed perceived self-efficacy in performing aggression, inhibiting aggression and using verbal persuasion skills, and the other assessed expected outcomes from behaving aggressively or prosocially. Results: Results showed that while reactive aggression was common in bullies and victims, proactive aggression was only characteristic of bullies. Both bullies and victims, compared to the other children, scored higher on hostile interpretation, anger, retaliation and ease of aggression. Bullies and followers claimed that it was easy for them to use verbal persuasion, while victims turned out to be the saddest group. All children, irrespective of their role in the peer group, thought that aggressive as well as prosocial behavior was more likely to produce desired results from a friendly peer than from an aggressive one. Conclusions: Bullies and victims seem to be similar in reactive aggression, SIP, and in the expression of anger, but the motivations which lead to their behavior may be different, as well as the final outcomes of their acts. © Association for Child Psychology and Psychiatry, 2004

Training elite youth soccer players: Area per player in small-sided games to replicate the match demands

The aim was to determine the area per player (ApP, m2 × player) in small- or large-sided games to replicate the official match demands in elite youth soccer players. Two hundred and twenty-eight players (U15 = 36, U16 = 48, U17 = 49, U18 = 37 and U19 = 58) were monitored during both training (12 183 individual samples) and matches (683 individual samples) across five seasons. Relative (m × min-1) total (TD), high-speed running (HSR), very high-speed running (VHSR), sprint and acceleration/deceleration (Acc/Dec) distance were collected. Between-category and between-position comparisons were performed. Area per player was moderately correlated (P < 0.05) with TD (r = 0.401), large (r = 0.621) with HSR, and very largely with VHSR (r = 0.744) and sprint (r = 0.723). An inverse small (r = -0.232; P = 0.039) correlation for Acc/Dec was found. The area per player to replicate the match demands was 158 ± 18, 182 ± 32, 197 ± 37, 212 ± 42 and 156 ± 25 m2 × player for TD, HSR, VHSR, sprint and Acc/Dec, respectively. Moderate to very large (ES: 0.79 to 4.66) differences in the area per player across metrics were observed, with sprint > VHSR > HSR > TD = Acc/Dec. Trivial to very large (ES: 0.01 to 2.67) between-category differences in area per player across the same metric were found, with U15 and U16 requiring a larger area per player than other age categories. These findings may help practitioners to recreate the desired external load outcomes with regards to positional match-play demands using specific area per player in small- or large-sided games in youth elite soccer players from U15 to U19

A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation.

Most MPN patients lacking JAK2 mutations harbour somatic CALR mutations that are thought to activate cytokine signalling although the mechanism is unclear. To identify kinases important for survival of CALR-mutant cells we developed a novel strategy (KISMET) which utilises the full range of kinase selectivity data available from each inhibitor and thus takes advantage of off-target noise that limits conventional siRNA or inhibitor screens. KISMET successfully identified known essential kinases in haematopoietic and non-haematopoietic cell lines and identified the MAPK pathway as required for growth of the CALR-mutated MARIMO cells. Expression of mutant CALR in murine or human haematopoietic cell lines was accompanied by MPL-dependent activation of MAPK signalling, and MPN patients with CALR mutations showed increased MAPK activity in CD34-cells, platelets and megakaryocytes. Although CALR mutations resulted in protein instability and proteosomal degradation, mutant CALR was able to enhance megakaryopoiesis and pro-platelet production from human CD34+ progenitors. These data link aberrant MAPK activation to the MPN phenotype and identify it as a potential therapeutic target in CALR-mutant positive MPNs.Leukemia accepted article preview online, 14 October 2016. doi:10.1038/leu.2016.280.Work in the Green lab is supported by Leukemia and Lymphoma Research, Cancer Research UK, the NIHR Cambridge Biomedical Research Centre, the Cambridge Experimental Cancer Medicine Centre and the Leukemia & Lymphoma Society of America. WW is supported by the Austrian Science Foundation (J 3578-B21). CGA is supported by Kay Kendall Leukaemia Fund clinical research fellowship. UM is supported by a Cancer Research UK Clinician Scientist Fellowship. Work in the Huntly lab is supported by the European Research Council, the MRC (UK), Bloodwise, the Cambridge NIHR funded BRC, KKLF and a WT/MRC Stem Cell centre grant. Work in the Green and Huntly Labs is supported by core support grants by the Wellcome Trust to the Cambridge Institute for Medical Research (100140/z/12/z) and Wellcome Trust-MRC Cambridge Stem Cell Institute (097922/Z/11/Z)