Un cas de thrombolyse a la phase aigüe d’un infarctus cerebral avec le tenecteplase au Congo

Nous rapportons un cas de thrombolyse utilisant le tenecteplase, d’évolution favorable chez un patient de 49 ans, hypertendu, tabagique, admis pour une hémiplégie et une hémihypoesthésie gauches associées à une dysarthrie et une désorientation temporospatiale. Le score NIHSS initial était à 18. Le scanner cérébral réalisé à 2h05 du début était normal avec un score ASPECT à 10. Il a bénéficié d’une thrombolyse avec le tenecteplase 0,1mg/kg à 3h10. L’évolution a été marquée par une régression du déficit neurologique avec un score NIHSS à 1 à 24 heures. Le scanner de contrôle a noté une dédifférenciation cortico-sous-corticale avec légère hypodensité dans le territoire postérieur de l’artère cérébrale moyenne droite. Le traitement par thrombolytique est possible en Afrique subsaharienne, en dépit de l’accès difficile aux médicaments.We report a case of thrombolysis using tenecteplase, with a good outcome in a patient of 49 years old, with history of hypertension and smoking, who was admitted with left hemiplegia and hypoesthesia associated with dysarthria and disorientation. The initial NIHSS score was 18. CT scan performed at the 2:05 start was normal with an ASPECT score to 10. He received thrombolysis with tenecteplase 0.1 mg / kg at 3:10. The 24h outcome was marked by a regression of the neurological deficit with an NIHSS score at 1. The CT scan noted a mild hypodensity in the posterior territory of the right middle cerebral artery. Thrombolysis in acute stroke is possible in Sub-Saharan Africa, despite a limit access to drugs

Study of proton-unbound states in 24Al^{24}{\rm Al} relevant for the 23Mg(p,γ)^{23}{\rm Mg}(p,\gamma) reaction in novae

Background: The nucleosynthesis of several proton-rich nuclei is determined by radiative proton-capture reactions on unstable nuclei in nova explosions. One such reaction is $^{23}{\rm Mg}(p,\gamma)^{24}{\rm Al}$, which links the NeNa and MgAl cycles in oxygen-neon (ONe) novae. Purpose: To extract $^{23}{\rm Mg}(p,\gamma)^{24}{\rm Al}$ resonance strengths from a study of proton-unbound states in $^{24}{\rm Al}$, produced via the $^{24}$Mg($^{3}$He,$t$) reaction. Methods: A beam of $^3 {\rm He}^{2+}$ ions at 50.7 MeV was used to produce the states of interest in $^{24}$Al. Proton-triton angular correlations were measured with a $K=600$ QDD magnetic spectrometer and a silicon detector array, located at iThemba LABS, South Africa. Results: We measured the excitation energies of the four lowest proton-unbound states in $^{24}$Al and place lower-limits on $\Gamma_p/\Gamma$ values for these four states. Together with USD-C shell-model calculations of partial gamma widths, the experimental data are also used to determine resonance strengths for the three lowest $^{23}{\rm Mg}(p,\gamma)^{24}{\rm Al}$ resonances. Conclusions: The energy of the dominant first $^{23}{\rm Mg}(p,\gamma)$ resonance is determined to be $E_{r} = 481.4 \pm 1.1$ keV, with a resonance strength $\omega \gamma = 18 \pm 6$ meV

138Ba(d,alpha) Study of States in 136Cs: Implications for New Physics Searches with Xenon Detectors

We used the 138Ba⁢( , ) reaction to carry out an in-depth study of states in 136Cs, up to around 2.5 MeV. In this Letter, we place emphasis on hitherto unobserved states below the first 1+ level, which are important in the context of solar neutrino and fermionic dark matter (FDM) detection in large-scale xenon-based experiments. We identify for the first time candidate metastable states in 136Cs, which would allow a real-time detection of solar neutrino and FDM events in xenon detectors, with high background suppression. Our results are also compared with shell-model calculations performed with three Hamiltonians that were previously used to evaluate the nuclear matrix element (NME) for 136Xe neutrinoless double beta decay. We find that one of these Hamiltonians, which also systematically underestimates the NME compared with the others, dramatically fails to describe the observed low-energy 136Cs spectrum, while the other two show reasonably good agreement

138Ba(d,α)^{138}{\rm Ba}(d,\alpha) study of states in 136Cs^{136}{\rm Cs}: Implications for new physics searches with xenon detectors

We used the $^{138}$Ba$(d,\alpha)$ reaction to carry out an in-depth study of states in $^{136}$Cs, up to around 2.5~MeV. In this work, we place emphasis on hitherto unobserved states below the first $1^+$ level, which are important in the context of solar neutrino and fermionic dark matter (FDM) detection in large-scale xenon experiments. We identify for the first time candidate metastable states in $^{136}$Cs, which would allow a real-time detection of solar neutrino and FDM events in xenon detectors, with high background suppression. Our results are also compared with shell-model calculations performed with three Hamiltonians that were previously used to evaluate the nuclear matrix element (NME) for $^{136}$Xe neutrinoless double beta decay. We find that one of these Hamiltonians, which also systematically underestimates the NME compared to the others, dramatically fails to describe the observed low-energy $^{136}$Cs spectrum, while the other two show reasonably good agreement

Observation of the 0+ 2 and γ bands in 98Ru, and shape coexistence in the Ru isotopes

Excited states in 98Ru were investigated using γ-ray spectroscopy following the β-decay of 98Rh, and via the 100Ru(p,t) reaction. Combining the results from the two experiments, two states were revised to have spin-parity of 4+ and subsequently assigned to the 02+ and “γ” bands, respectively. The observed structures in 98Ru are suggested to be deformed and rotational, rather than spherical and vibrational, and fit well into the systematics of these excitations in the Ru isotopes. The 02+ excitation is suggested as a shape coexisting configuration. This observation eliminates some of the last remaining candidates for nearly harmonic vibrational nuclei in the Z≈50 region. Beyond-mean-field calculations are presented that support shape coexistence throughout the Ru isotopes with N=52–62, and suggest a smooth evolution of the shape

Investigations of the structures of the Ru isotopes: 98Ru

As part of a systematic study of the nuclear structure of the Ru isotopes, 98Ru was investigated via the β-decay of 98Rh at iThemba LABS, and the 100Ru(p, t) reaction at the Maier-Leibnitz Laboratory. The combined data results in significant revision of the previous spin assignments and clarification of the nature of levels in 98Ru, as well as providing insights into the evolution of the structures across the Ru isotopic chain

Isospin mixing and the cubic isobaric multiplet mass equation in the lowest <i>T</i>=2, <i>A</i>=32 quintet

The isobaric multiplet mass equation (IMME) is known to break down in the first T = 2, A = 32 isospin quintet. In this work we combine high-resolution experimental data with state-of-the-art shell-model calculations to investigate isospin mixing as a possible cause for this violation. The experimental data are used to validate isospin-mixing matrix elements calculated with newly developed shell-model Hamiltonians. Our analysis shows that isospin mixing with nonanalog T = 1 states contributes to the IMME breakdown, making the requirement of an anomalous cubic term inevitable for the multiplet

Fundamental Symmetries, Neutrons, and Neutrinos (FSNN): Whitepaper for the 2023 NSAC Long Range Plan

This whitepaper presents the research priorities decided on by attendees of the 2022 Town Meeting for Fundamental Symmetries, Neutrons and Neutrinos, which took place December 13-15, 2022 in Chapel Hill, NC, as part of the Nuclear Science Advisory Committee (NSAC) 2023 Long Range Planning process. A total of 275 scientists registered for the meeting. The whitepaper makes a number of explicit recommendations and justifies them in detail