Pengembangan Model Latihan Pliometrik Three Point-shoot Bolabasket Menggunakan Stimulasi Pleksus Brakhialis pada Siswa Ekstrakurikuler di SMA

The aim of this research is to develop a model of exercise of pliometrik three-point shoot using the stimulation of Brakhialis Plexus for high school students joining extracurricular in Smart School Brawijaya Malang. Based on 10 measures of research and development by Borg and Gall, this study used 7 steps adapting the characteristics and conditions that will be examined. The average percentage of the validity of the tryout results 82%, small group and large group trial of 85.8%. After the final revision stage, this study resulted 6 model exercises for three shots

Alterations in Cortical Sensorimotor Connectivity following Complete Cervical Spinal Cord Injury: A Prospective Resting-State fMRI Study

Functional magnetic resonance imaging (fMRI) studies have demonstrated alterations during task-induced brain activation in spinal cord injury (SCI) patients. The interruption to structural integrity of the spinal cord and the resultant disrupted flow of bidirectional communication between the brain and the spinal cord might contribute to the observed dynamic reorganization (neural plasticity). However, the effect of SCI on brain resting-state connectivity patterns remains unclear. We undertook a prospective resting-state fMRI (rs-fMRI) study to explore changes to cortical activation patterns following SCI. With institutional review board approval, rs-fMRI data was obtained in eleven patients with complete cervical SCI (\u3e2 years post injury) and nine age-matched controls. The data was processed using the Analysis of Functional Neuroimages software. Region of interest (ROI) based analysis was performed to study changes in the sensorimotor network using pre- and post-central gyri as seed regions. Two-sampled t-test was carried out to check for significant differences between the two groups. SCI patients showed decreased functional connectivity in motor and sensory cortical regions when compared to controls. The decrease was noted in ipsilateral, contralateral, and interhemispheric regions for left and right precentral ROIs. Additionally, the left postcentral ROI demonstrated increased connectivity with the thalamus bilaterally in SCI patients. Our results suggest that cortical activation patterns in the sensorimotor network undergo dynamic reorganization following SCI. The presence of these changes in chronic spinal cord injury patients is suggestive of the inherent neural plasticity within the central nervous system

Evaluation of Whole-Brain Resting-State Functional Connectivity in Spinal Cord Injury - A Large-Scale Network Analysis Using Network Based Statistic

Large-scale network analysis characterizes the brain as a complex network of nodes and edges to evaluate functional connectivity patterns. The utility of graph-based techniques has been demonstrated in an increasing number of restingstate functional MRI (rs-fMRI) studies in the normal and diseased brain. However, to our knowledge, graph theory has not been used to study the reorganization pattern of resting-state brain networks in patients with traumatic complete spinal cord injury (SCI). In the present analysis, we applied a graph-theoretical approach to explore changes to global brain network architecture as a result of SCI. Fifteen subjects with chronic (\u3e 2 years) complete (American Spinal Injury Association [ASIA] A) cervical SCI and 15 neurologically intact controls were scanned using rs-fMRI. The data were preprocessed followed by parcellation of the brain into 116 regions of interest (ROI) or nodes. The average time series was extracted at each node, and correlation analysis was performed between every pair of nodes. A functional connectivity matrix for each subject was then generated. Subsequently, the matrices were averaged across groups, and network changes were evaluated between groups using the network-based statistic (NBS) method. Our results showed decreased connectivity in a subnetwork of the whole brain in SCI compared with control subjects. Upon further examination, increased connectivity was observed in a subnetwork of the sensorimotor cortex and cerebellum network in SCI. In conclusion, our findings emphasize the applicability of NBS to study functional connectivity architecture in diseased brain states. Further, we show reorganization of large-scale resting-state brain networks in traumatic SCI, with potential prognostic and therapeutic implications

International validation of a urinary biomarker panel for identification of active lupus nephritis in children.

Conventional markers of juvenile-onset systemic lupus erythematosus (JSLE) disease activity fail to adequately identify lupus nephritis (LN). While individual novel urine biomarkers are good at detecting LN flares, biomarker panels may improve diagnostic accuracy. The aim of this study was to assess the performance of a biomarker panel to identify active LN in two international JSLE cohorts.Novel urinary biomarkers, namely vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein 1 (MCP-1), lipocalin-like prostaglandin D synthase (LPGDS), transferrin (TF), ceruloplasmin, alpha-1-acid glycoprotein (AGP) and neutrophil gelatinase-associated lipocalin (NGAL), were quantified in a cross-sectional study that included participants of the UK JSLE Cohort Study (Cohort 1) and validated within the Einstein Lupus Cohort (Cohort 2). Binary logistic regression modelling and receiver operating characteristic curve analysis [area under the curve (AUC)] were used to identify and assess combinations of biomarkers for diagnostic accuracy.A total of 91 JSLE patients were recruited across both cohorts, of whom 31 (34 %) had active LN and 60 (66 %) had no LN. Urinary AGP, ceruloplasmin, VCAM-1, MCP-1 and LPGDS levels were significantly higher in those patients with active LN than in non-LN patients [all corrected p values (p c) < 0.05] across both cohorts. Urinary TF also differed between patient groups in Cohort 2 (p c = 0.001). Within Cohort 1, the optimal biomarker panel included AGP, ceruloplasmin, LPGDS and TF (AUC 0.920 for active LN identification). These results were validated in Cohort 2, with the same markers resulting in the optimal urine biomarker panel (AUC 0.991).In two international JSLE cohorts, urinary AGP, ceruloplasmin, LPGDS and TF demonstrate an 'excellent' ability for accurately identifying active LN in children

Effects of Sowing Date on Yield and Yield Parameters of Some Groundnut (Arachis hypogaea L.) Cultivar Under Rainfed Condition in Ogbomoso, Nigeria

The study examined the variation in number of flowers, number of nodules, number of pods and seed yield of some groundnut cultivar as affected by planting date in Ogbomoso, Oyo state, Nigeria under rainfed condition. This is necessary to determine when moisture availability will be at optimum starting from the onset of rainfall, to avert loss which could arise from improper timing of planting. Teaching and Research Farm of Ladoke Akintola University of Technology Ogbomoso with average annual rainfall of 1000 mm and temperature ranging from 28 to 33 ºC was used for the experiment. A 4 by 4 factorial experiment with four varieties of groundnut (three improved varieties Samnut-10, Samnut-23, Samnut-22 and Kampala (local variety)) and four planting dates of a week interval (29th April, 6th May, 13th May and 20th May, 2016) were tried without chemical amendment. All the parameters evaluated were affected by the planting date.  Samnut-23 and Samnut-10 planted on 29th April produced the highest mean number of flowers (15.67) and number of nodules (116.00) respectively which were significantly higher than others. Cultivar type did not have significant influence (p≤0.05) on the growth parameters. However, number of pods and seed yield was influenced by the cultivar. The highest number of pods (103.00) from this study was produced by Samnut-23 planted on 29th April. It was observed that the high number of pods produced by Samnut-23 did not translate to seed yield because Kampala produced the highest seed yield (73.51 g/plot) which was significantly higher than yield from other cultivars tried. Groundnut cultivars responded differently to planting date tried, with best planting period being early month of May. It was observed that all the cultivars produced their least seed yield when planted towards the end of month of May, therefore, should be discouraged for the tried cultivars at the trial location. KEYWORDS: Sowing date, Rainfed, Pod, Seed yield and Groundnut Production DOI: 10.7176/JNSR/9-18-06 Publication date:September 30th 201

Evaluation of the potency of Newcastle disease vaccine from veterinary outlets in Abeokuta, Ogun State, Nigeria

Vaccination against Newcastle disease (ND) is the most reliable tool in its prevention and control, it is therefore important that vaccines used are of good quality. This study was conducted to assess the quality of live ND vaccines sold in Abeokuta over a six months’ period. Live Newcastle disease vaccines were purchased from ten different veterinary sales outlets and their antigenic titres were determined using Hemagglutination assay (HA). The results revealed a difference in antigenic titres amongst the various ND vaccines sold in Abeokuta with only 20.33 % having high titre, 55.9 % having an average titre, and 23.7 % having low titre. The vaccine titres varied between different brands with storage and handling as contributing factors to the variations. Antigenic titre contained in vaccines properly stored showed significantly (p&lt;0.05) higher antigenic titre and vaccines that were close to their expiration dates had lower titres. Newcastle disease vaccines in Abeokuta are of average titres, it is therefore necessary that adequate evaluation of ND vaccines be recommended before use in flocks and owners of vaccine sales outlets be educated on the need for proper handling and storage of these biologicals

Addressing the under-reporting of adverse drug reactions in public health programs controlling HIV/AIDS, tuberculosis and malaria: A prospective cohort study

Background Adverse Drug Reactions (ADRs) are a major clinical and public health problem world-wide. The prompt reporting of suspected ADRs to regulatory authorities to activate drug safety surveillance and regulation appears to be the most pragmatic measure for addressing the problem. This paper evaluated a pharmacovigilance (PV) training model that was designed to improve the reporting of ADRs in public health programs treating the Human Immunodeficiency Virus (HIV), Tuberculosis (TB) and Malaria. Methods A Structured Pharmacovigilance and Training Initiative (SPHAR-TI) model based on the World Health Organization accredited Structured Operational Research and Training Initiative (SOR-IT) model was designed and implemented over a period of 12 months. A prospective cohort design was deployed to evaluate the outcomes of the model. The primary outcomes were knowledge gained and Individual Case Safety Reports (ICSR) (completed adverse drug reactions monitoring forms) submitted, while the secondary outcomes were facility based Pharmacovigilance Committees activated and health facility healthcare workers trained by the participants. Results Fifty-five (98%) participants were trained and followed up for 12 months. More than three quarter of the participants have never received training on pharmacovigilance prior to the course. Yet, a significant gain in knowledge was observed after the participants completed a comprehensive training for six days. In only seven months, 3000 ICSRs (with 100% completeness) were submitted, 2,937 facility based healthcare workers trained and 46 Pharmacovigilance Committees activated by the participants. Overall, a 273% increase in ICSRs submission to the National Agency for Food and Drug Administration and Control (NAFDAC) was observed. Conclusion Participants gained knowledge, which tended to increase the reporting of ADRs. The SPHAR-TI model could be an option for strengthening the continuous reporting of ADRs in public health programs in resource limited settings

EMPLOYEE’S RETENTION STRATEGIES AND PERFORMANCE IN NIGERIA’S PUBLIC SECTOR

Employee retention strategies are becoming the most critical workforce management challenges in the dynamic business environments. Public Organizations in Nigeria are operating in highly competitive environment owing to today’s rapidly moving dynamic, uncertain and highly competitive global markets. This study aims to examine the impact of employee retention strategies on performance of Nigeria’s public sector. Secondary data obtained from relevant books, journals, websites resource were gathered and analyzed to accomplish this objective. Findings of the study establish the significance that employee retention strategies have on public sector performance in Nigeria. Moreover, the findings revealed the implication of labour turnover in the public sector and the strategies for its avoidance. In view of this, the paper argues that governments in Nigeria need to put in place, adequate employee retention policies that encourage and make employees feel valued. In addition, the conditions of services and other retention strategies in the public sector should be reviewed in line with the current economic situation of the country. These steps are necessary to achieve the much needed quality performance in the Nigeria’s public sector