Cultural heritage and community engagement : exploring participatory approaches in Nepal

Community engagement in Cultural Heritage Management is not a popular practice in Nepal. However, recent political transformations that emphasize inclusive participation in development projects have started to allow local communities to enter into the heritage management process. Within this new relationship, there appear to be two key concerns for local communities: the distribution of revenue generated from heritage; and an ability to participate more fully in the design and management of such enterprises. Using semi-structured interviews with community stakeholders and heritage management authorities at two case study sites in Kathmandu – Boudhanath Stupa and Rani-Pokhari – this research aims to explore whether or not decentralized grassroots engagements with cultural heritage in Nepal provides a more effective and sustainable management strategy. This research is an evaluative study of contemporary policy on cultural heritage management in Kathmandu, and ultimately aims to contribute to heritage debates by offering a new perspective on community engagement specific to the post-disaster, post-development Nepalese context

Evaluating Hydrological Model Performances on Stream Flow Simulation with Agricultural Management

Two comprehensive agricultural watershed-scale hydrological models: Soil and Water Assessment Tool (SWAT), and Annualized Agricultural Non-Point Source Pollution Model (AnnAGNPS), have been widely used for evaluating agricultural Best Management Practice (BMP). In this study, models were developed for the Big Sunflower River Watershed (BSRW) in Mississippi, USA. Both hydrological models were successfully calibrated and validated for predicting monthly stream flow discharges from three USGS gages (Merigold, Sunflower, and Leland) within the BSRW. The model performances were reasonable with R2 and NSE values range from 0.45 to 0.84 for SWAT, and from 0.34 to 0.66 for AnnAGNPS. Both models predicted lower stream flow discharge with conservation tillage practice as compare to conventional tillage practice BMP evaluated in this study. Overall, results showed that both SWAT and AnnAGNPS models successfully simulated hydrological conditions of the watershed with agricultural BMP, and these models can be useful for making hydrological decisions related to agricultural watershed managements. Keywords: SWAT, AnnAGNPS, tillage, streamflow, hydrology, BMP DOI: 10.7176/JEP/12-3-03 Publication date: January 31st 202

ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity

Obesity is increasing in prevalence and is strongly associated with metabolic and cardiovascular disorders. The renin-angiotensin system (RAS) has emerged as a key pathogenic mechanism for these disorders; angiotensin (Ang)-converting enzyme 2 (ACE2) negatively regulates RAS by metabolizing Ang II into Ang 1-7. We studied the role of ACE2 in obesity-mediated cardiac dysfunction. ACE2 null (ACE2KO) and wild-type (WT) mice were fed a high-fat diet (HFD) or a control diet and studied at 6 months of age. Loss of ACE2 resulted in decreased weight gain but increased glucose intolerance, epicardial adipose tissue (EAT) inflammation, and polarization of macrophages into a proinflammatory phenotype in response to HFD. Similarly, human EAT in patients with obesity and heart failure displayed a proinflammatory macrophage phenotype. Exacerbated EAT inflammation in ACE2KO-HFD mice was associated with decreased myocardial adiponectin, decreased phosphorylation of AMPK, increased cardiac steatosis and lipotoxicity, and myocardial insulin resistance, which worsened heart function. Ang 1-7 (24 µg/kg/h) administered to ACE2KO-HFD mice resulted in ameliorated EAT inflammation and reduced cardiac steatosis and lipotoxicity, resulting in normalization of heart failure. In conclusion, ACE2 plays a novel role in heart disease associated with obesity wherein ACE2 negatively regulates obesity-induced EAT inflammation and cardiac insulin resistance

Urinary and Plasma Fluoride Levels in Pregnant Women from Mexico City

Background There is need to assess the developmental neurotoxicity of fluoride. Our knowledge of prenatal fluoride exposure is challenged as few population-based studies have been conducted and these generally date back several decades, provide incomplete data on sociodemographic variables, and have methodological limitations. Objective To measure urinary and plasma fluoride levels across three time points in pregnant mothers who were enrolled in the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) birth cohort study. Methods Fluoride levels were characterized in archived urine and plasma from 872 pregnant mothers sampled from the ELEMENT cohort. Various statistical methods were used to analyze the fluoride data with particular consideration for changes across three stages of pregnancy and against sociodemographic variables. Results All samples had detectable levels of fluoride. The mean urinary and plasma fluoride levels were 0.91 and 0.0221 mg/L respectively, and these were not statistically different across three stages of pregnancy. Fluoride levels correlated across the stages of pregnancy studied, with stronger correlations between neighboring stages. Urinary fluoride changed as pregnancy progressed with levels increasing until ~23 weeks and then decreasing until the end of pregnancy. For plasma fluoride, there was a decreasing trend but this was not of statistical significance. Creatinine-adjusted urinary fluoride levels did not associate consistently with any of the sociodemographic variables studied. Conclusions This study provides the most extensive characterization to date of fluoride exposure throughout pregnancy. These results provide the foundation to explore exposure-related health outcomes in the ELEMENT cohort and other studies

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV

Search for direct stau production in events with two hadronic tau-leptons in root s=13 TeV pp collisions with the ATLAS detector

A search for the direct production of the supersymmetric partners ofτ-leptons (staus) in final stateswith two hadronically decayingτ-leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of139fb−1, recorded with the ATLAS detector at the LargeHadron Collider at a center-of-mass energy of 13 TeV. No significant deviation from the expected StandardModel background is observed. Limits are derived in scenarios of direct production of stau pairs with eachstau decaying into the stable lightest neutralino and oneτ-lepton in simplified models where the two staumass eigenstates are degenerate. Stau masses from 120 GeV to 390 GeV are excluded at 95% confidencelevel for a massless lightest neutralino