Sequential critical periods for the development of binaural integration in the infant mouse auditory cortex

Early binaural experience can recalibrate central auditory circuits that support spatial hearing. However, it is not known how binaural integration matures shortly after hearing onset or whether various developmental stages are differentially impacted by disruptions of normal binaural experience. Here we induce a brief, reversible unilateral conductive hearing loss (CHL) at several experimentally determined milestones in mouse primary auditory cortex (A1) development and characterize its effects approximately one week after normal hearing is restored. We find that experience shapes A1 binaural selectivity during two early critical periods. CHL before P16 disrupts the normal co-registration of interaural frequency tuning, whereas CHL on P16, but not before or after, disrupts interaural level difference (ILD) sensitivity contained in long-latency spikes. These data highlight an evolving plasticity in the developing auditory cortex that may relate to the etiology of amblyaudia, a binaural hearing impairment associated with bouts of otitis media during human infancy

The Color--Flavor Transformation of induced QCD

The Zirnbauer's color-flavor transformation is applied to the $U(N_c)$ lattice gauge model, in which the gauge theory is induced by a heavy chiral scalar field sitting on lattice sites. The flavor degrees of freedom can encompass several `generations' of the auxiliary field, and for each generation, remaining indices are associated with the elementary plaquettes touching the lattice site. The effective, color-flavor transformed theory is expressed in terms of gauge singlet matrix fields carried by lattice links. The effective action is analyzed for a hypercubic lattice in arbitrary dimension. We investigate the corresponding d=2 and d=3 dual lattices. The saddle points equations of the model in the large-$N_c$ limit are discussed.Comment: 24 pages, 6 figures, to appear in Int. J. Mod. Phys.

Observation of surface states on heavily indium doped SnTe(111), a superconducting topological crystalline insulator

The topological crystalline insulator tin telluride is known to host superconductivity when doped with indium (Sn$_{1-x}$In$_{x}$Te), and for low indium contents ($x=0.04$) it is known that the topological surface states are preserved. Here we present the growth, characterization and angle resolved photoemission spectroscopy analysis of samples with much heavier In doping (up to $x\approx0.4$), a regime where the superconducting temperature is increased nearly fourfold. We demonstrate that despite strong p-type doping, Dirac-like surface states persist

Monte Carlo Simulation Calculation of Critical Coupling Constant for Continuum \phi^4_2

We perform a Monte Carlo simulation calculation of the critical coupling constant for the continuum {\lambda \over 4} \phi^4_2 theory. The critical coupling constant we obtain is [{\lambda \over \mu^2}]_crit=10.24(3).Comment: 11 pages, 4 figures, LaTe

Hearing the light: neural and perceptual encoding of optogenetic stimulation in the central auditory pathway

Optogenetics provides a means to dissect the organization and function of neural circuits. Optogenetics also offers the translational promise of restoring sensation, enabling movement or supplanting abnormal activity patterns in pathological brain circuits. However, the inherent sluggishness of evoked photocurrents in conventional channelrhodopsins has hampered the development of optoprostheses that adequately mimic the rate and timing of natural spike patterning. Here, we explore the feasibility and limitations of a central auditory optoprosthesis by photoactivating mouse auditory midbrain neurons that either express channelrhodopsin-2 (ChR2) or Chronos, a channelrhodopsin with ultra-fast channel kinetics. Chronos-mediated spike fidelity surpassed ChR2 and natural acoustic stimulation to support a superior code for the detection and discrimination of rapid pulse trains. Interestingly, this midbrain coding advantage did not translate to a perceptual advantage, as behavioral detection of midbrain activation was equivalent with both opsins. Auditory cortex recordings revealed that the precisely synchronized midbrain responses had been converted to a simplified rate code that was indistinguishable between opsins and less robust overall than acoustic stimulation. These findings demonstrate the temporal coding benefits that can be realized with next-generation channelrhodopsins, but also highlight the challenge of inducing variegated patterns of forebrain spiking activity that support adaptive perception and behavior

Non-Gaussian fixed point in four-dimensional pure compact U(1) gauge theory on the lattice

The line of phase transitions, separating the confinement and the Coulomb phases in the four-dimensional pure compact U(1) gauge theory with extended Wilson action, is reconsidered. We present new numerical evidence that a part of this line, including the original Wilson action, is of second order. By means of a high precision simulation on homogeneous lattices on a sphere we find that along this line the scaling behavior is determined by one fixed point with distinctly non-Gaussian critical exponent nu = 0.365(8). This makes the existence of a nontrivial and nonasymptotically free four-dimensional pure U(1) gauge theory in the continuum very probable. The universality and duality arguments suggest that this conclusion holds also for the monopole loop gas, for the noncompact abelian Higgs model at large negative squared bare mass, and for the corresponding effective string theory.Comment: 11 pages, LaTeX, 2 figure

Charged hadrons in local finite-volume QED+QCD with C⋆ boundary conditions

In order to calculate QED corrections to hadronic physical quantities by means of lattice simulations, a coherent description of electrically-charged states in finite volume is needed. In the usual periodic setup, Gauss's law and large gauge transformations forbid the propagation of electrically-charged states. A possible solution to this problem, which does not violate the axioms of local quantum field theory, has been proposed by Wiese and Polley, and is based on the use of C* boundary conditions. We present a thorough analysis of the properties and symmetries of QED in isolation and QED coupled to QCD, with C* boundary conditions. In particular we learn that a certain class of electrically-charged states can be constructed in this setup in a fully consistent fashion, without relying on gauge fixing. We argue that this class of states covers most of the interesting phenomenological applications in the framework of numerical simulations. We also calculate finite-volume corrections to the mass of stable charged particles and show that these are much smaller than in non-local formulations of QED

London relation and fluxoid quantization for monopole currents in U(1) lattice gauge theory

We explore the analogy between quark confinement and the Meissner effect in superconductors. We measure the response of color-magnetic "supercurrents" from Dirac magnetic monopoles to the presence of a static quark-antiquark pair in four dimensional U(1) lattice gauge theory. Our results indicate that in the confined phase these currents screen the color-electric flux due to the quarks in an electric analogy of the Meisner effect. We show that U(1) lattice guage theory obeys both a dual London equation and an electric fluxoid quantization condition.Comment: LSUHEP-1-92 May 1992, 13 page

The Perturbative Pole Mass in QCD

It is widely believed that the pole mass of a quark is infrared-finite and gauge-independent to all orders in perturbation theory. This seems not to have been proved in the literature. A proof is provided here.Comment: 12 pages REVTeX with 2 figures; archiving published version with note and references added. If you thought this was proven long ago see http://www-theory.fnal.gov/people/ask/TeX/mPole