Classes of fast and specific search mechanisms for proteins on DNA

Problems of search and recognition appear over different scales in biological systems. In this review we focus on the challenges posed by interactions between proteins, in particular transcription factors, and DNA and possible mechanisms which allow for a fast and selective target location. Initially we argue that DNA-binding proteins can be classified, broadly, into three distinct classes which we illustrate using experimental data. Each class calls for a different search process and we discuss the possible application of different search mechanisms proposed over the years to each class. The main thrust of this review is a new mechanism which is based on barrier discrimination. We introduce the model and analyze in detail its consequences. It is shown that this mechanism applies to all classes of transcription factors and can lead to a fast and specific search. Moreover, it is shown that the mechanism has interesting transient features which allow for stability at the target despite rapid binding and unbinding of the transcription factor from the target.Comment: 65 pages, 23 figure

R-matrix Quantization of the Elliptic Ruijsenaars--Schneider model

It is shown that the classical L-operator algebra of the elliptic Ruijsenaars-Schneider model can be realized as a subalgebra of the algebra of functions on the cotangent bundle over the centrally extended current group in two dimensions. It is governed by two dynamical r and $\bar{r}$-matrices satisfying a closed system of equations. The corresponding quantum R and $\overline{R}$-matrices are found as solutions to quantum analogs of these equations. We present the quantum L-operator algebra and show that the system of equations on R and $\overline{R}$ arises as the compatibility condition for this algebra. It turns out that the R-matrix is twist-equivalent to the Felder elliptic R^F-matrix with $\overline{R}$ playing the role of the twist. The simplest representation of the quantum L-operator algebra corresponding to the elliptic Ruijsenaars-Schneider model is obtained. The connection of the quantum L-operator algebra to the fundamental relation RLL=LLR with Belavin's elliptic R matrix is established. As a byproduct of our construction, we find a new N-parameter elliptic solution to the classical Yang-Baxter equation.Comment: latex, 29 pages, some misprints are corrected and the meromorphic version of the quantum L-operator algebra is discusse

The Positive Impact of Negative Feedback

While feedback is an essential element of performance, there is little theory explaining the effects of negative feedback. Disagreement exists as to whether negative feedback is good or bad and this impacts its use. Fortunately, control theory provides scholars with an opportunity to better understand negative feedback and the conditions necessary to support its intended function. This study examined the relationship between negative feedback and task performance in a leadership development environment. This work asserts that performance is contingent on perceived feedback usefulness, such that the relationship is stronger when feedback usefulness is high and weaker when it is low. In addition, this research led to the creation of a new instrument to measure perceptions of feedback usefulness as an antecedent of effective feedback. Results indicate positive effects of negative feedback on performance, with moderating effects of feedback usefulness on four post-feedback tasks. Analysis also demonstrated that the newly developed feedback usefulness scale demonstrates good model fit (evaluated by confirmatory factor analysis) and strong internal consistency reliability (Cronbach’s α)

ZnZ_n elliptic Gaudin model with open boundaries

The $Z_n$ elliptic Gaudin model with integrable boundaries specified by generic non-diagonal K-matrices with $n+1$ free boundary parameters is studied. The commuting families of Gaudin operators are diagonalized by the algebraic Bethe ansatz method. The eigenvalues and the corresponding Bethe ansatz equations are obtained.Comment: 21 pages, Latex fil

Population policies and education: exploring the contradictions of neo-liberal globalisation

The world is increasingly characterised by profound income, health and social inequalities (Appadurai, 2000). In recent decades development initiatives aimed at reducing these inequalities have been situated in a context of increasing globalisation with a dominant neo-liberal economic orthodoxy. This paper argues that neo-liberal globalisation contains inherent contradictions regarding choice and uniformity. This is illustrated in this paper through an exploration of the impact of neo-liberal globalisation on population policies and programmes. The dominant neo-liberal economic ideology that has influenced development over the last few decades has often led to alternative global visions being overlooked. Many current population and development debates are characterised by polarised arguments with strongly opposing aims and views. This raises the challenge of finding alternatives situated in more middle ground that both identify and promote the socially positive elements of neo-liberalism and state intervention, but also to limit their worst excesses within the population field and more broadly. This paper concludes with a discussion outling the positive nature of middle ground and other possible alternatives

Ninth and Tenth Order Virial Coefficients for Hard Spheres in D Dimensions

We evaluate the virial coefficients B_k for k<=10 for hard spheres in dimensions D=2,...,8. Virial coefficients with k even are found to be negative when D>=5. This provides strong evidence that the leading singularity for the virial series lies away from the positive real axis when D>=5. Further analysis provides evidence that negative virial coefficients will be seen for some k>10 for D=4, and there is a distinct possibility that negative virial coefficients will also eventually occur for D=3.Comment: 33 pages, 12 figure

Effect of Hormodin A, a growth substance, on the rooting of cuttings

Florists, nurserymen and gardeners are deeply interested in recent discoveries that certain chemical compounds, when absorbed into the appropriate living plant tissues, induce or stimulate the initiation of roots. Depending on species, point of application of the chemical and various environmental conditions, roots appear on stems or leaves at points where roots do not ordinarily arise. The chemicals used have been variously designated by different investigators as growth substances (6), hormones (3), phytohormones (28) and auxins (28). When applied to the rootage of cuttings, these substances may have a wide practical use. Some of the most effective growth substances are offered to the trade under proprietary names. This bulletin deals with a series of experiments designed to test, under Iowa conditions, the efficacy of Hormodin A, a widely distributed trade product known to contain an effective growth-promoting chemical, indolebutyric acid, for the rooting of cuttings of many species and varieties of horticultural plants. The project was sponsored by the Boyce Thompson Institute for Plant Research, located at Yonkers, N. Y., under a cooperative agreement with the Iowa Agricultural Experiment Station. The study covered a period of 2 years and included tests with approximately 50 species and varieties. The immediate objectives of the research were: 1. To discover the most effective concentration of Hormodin A for the rooting of each species or variety; ~. to determine the effect of the treatment on cuttings taken at different stages of maturity; 3. to determine the reaction of cuttings taken at different seasons of the year to the treatments