Resistance to carbapenems in non-typhoidal Salmonella enterica serovars from humans, animals and food

Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial drug resistance in different settings. Of particular concern is the resistance to critical “last resort” antimicrobials, such as carbapenems. In contrast to other Enterobacteriaceae (e.g., Klebsiella pneumoniae, Escherichia coli, and Enterobacter, which are major nosocomial pathogens affecting debilitated and immunocompromised patients), carbapenem resistance is still very rare in NTS. Nevertheless, it has already been detected in isolates recovered from humans, companion animals, livestock, wild animals, and food. Five carbapenemases with major clinical importance—namely KPC (Klebsiella pneumoniae carbapenemase) (class A), IMP (imipenemase), NDM (New Delhi metallo-β-lactamase), VIM (Verona integron-encoded metallo-β-lactamase) (class B), and OXA-48 (oxacillinase, class D)—have been reported in NTS. Carbapenem resistance due to the production of extended spectrum- or AmpC β-lactamases combined with porin loss has also been detected in NTS. Horizontal gene transfer of carbapenemase-encoding genes (which are frequently located on self-transferable plasmids), together with co- and cross-selective adaptations, could have been involved in the development of carbapenem resistance by NTS. Once acquired by a zoonotic bacterium, resistance can be transmitted from humans to animals and from animals to humans through the food chain. Continuous surveillance of resistance to these “last resort” antibiotics is required to establish possible links between reservoirs and to limit the bidirectional transfer of the encoding genes between S. enterica and other commensal or pathogenic bacteria

The Jet-Driven Outflow In The Radio Galaxy SDSS J1517+3353: Implications For Double-Peaked Narrow-Line Active Galactic Nucleus

We report on the study of an intriguing active galaxy that was selected as a potential multiple supermassive black hole merger in the early-type host SDSS J151709.20+335324.7 (z = 0.135) from a complete search for double-peaked [O III] lines from the SDSS spectroscopic quasi-stellar object (QSO) database. Ground-based SDSS imaging reveals two blue structures on either side of the photometric center of the host galaxy, separated from each other by about 5.7 kpc. From a combination of SDSS fiber and Keck/HIRES long-slit spectroscopy, it is demonstrated that, in addition to these two features, a third distinct structure surrounds the nucleus of the host galaxy. All three structures exhibit highly ionized line emission with line ratios characteristic of Seyfert II active galactic nuclei. The analysis of spatially resolved emission-line profiles from the HIRES spectrum reveal three distinct kinematic subcomponents, one at rest and the other two moving at -350 km s(-1) and 500 km s(-1) with respect to the systemic velocity of the host galaxy. A comparison of imaging and spectral data confirm a strong association between the kinematic components and the spatial knots, which implies a highly disturbed and complex active region in this object. A comparative analysis of the broadband positions, colors, kinematics, and spectral properties of the knots in this system lead to two plausible explanations: (1) a multiple active galactic nucleus (AGN) produced due to a massive dry merger, or (2) a very powerful radio jet-driven outflow. Subsequent VLA radio imaging reveals a clear jet aligned with the emission-line gas, confirming the latter explanation. We use the broadband radio measurements to examine the impact of the jet on the interstellar medium of the host galaxy, and find that the energy in the radio lobes can heat a significant fraction of the gas to the virial temperature. Finally, we discuss tests that may help future surveys distinguish between jet-driven kinematics and true black-hole binaries. J1517+3353 is a remarkable laboratory for AGN feedback and warrants deeper follow-up study. In the Appendix, we present high-resolution radio imaging of a second AGN with double-peaked [O III] lines, SDSS J112939.78+605742.6, which shows a sub-arcsecond radio jet. If the double-peaked nature of the narrow lines in radio-loud AGNs are generally due to radio jet interactions, we suggest that extended radio structure should be expected in most of such systems.NSF AST-0507483, AST-0808133University of Texas at AustinAlfred P. Sloan FoundationParticipating InstitutionsNational Aeronautics and Space AdministrationU.S. Department of EnergyJapanese MonbukagakushoMax Planck SocietyAstronom

Detection of Tiny Mechanical Motion by Means of the Ratchet Effect

We propose a position detection scheme for a nanoelectromechanical resonator based on the ratchet effect. This scheme has an advantage of being a dc measurement. We consider a three-junction SQUID where a part of the superconducting loop can perform mechanical motion. The response of the ratchet to a dc current is sensitive to the position of the resonator and the effect can be further enhanced by biasing the SQUID with an ac current. We discuss the feasibility of the proposed scheme in existing experimental setups.Comment: 8 pages, 9 figure

Center-commissioned external review of International Water Management Institute: Consolidated report, 19-29 May 2003

Agricultural research / Research institutes / Research policy / Research priorities / Planning / Monitoring / Evaluation / Financial resources / Gender

A VLBA search for binary black holes in active galactic nuclei with double-peaked optical emission line spectra

We have examined a subset of 11 active galactic nuclei (AGN) drawn from a sample of 87 objects that possess double-peaked optical emission line spectra, as put forward by Wang et al. (2009a) and are detectable in the FIRST survey at radio wavelengths. The double-peaked nature of the optical emission line spectra has been suggested as evidence for the existence of binary black holes in these AGN, although this interpretation is controversial. We make a simple suggestion, that direct evidence of binary black holes in these objects could be searched for in the form of dual sources of compact radio emission associated with the AGN. To explore this idea, we have used the Very Long Baseline Array to observe these 11 objects from the Wang et al. (2009a) sample. Of the 11 objects, we detect compact radio emission from two, SDSS J151709+335324 and SDSS J160024+264035. Both objects show single components of compact radio emission. The morphology of SDSS J151709+335324 is consistent with a recent comprehensive multi-wavelength study of this object by Rosario et al. (2010). Assuming that the entire sample consists of binary black holes, we would expect of order one double radio core to be detected, based on radio wavelength detection rates from FIRST and VLBI surveys. We have not detected any double cores, thus this work does not substantially support the idea that AGN with double-peaked optical emission lines contain binary black holes. However, the study of larger samples should be undertaken to provide a more secure statistical result, given the estimated detection rates.Comment: 14 pages, 3 figures. To appear in A

Full Counting Statistics in Strongly Interacting Systems: Non-Markovian Effects

We present a theory of full counting statistics for electron transport through interacting electron systems with non-Markovian dynamics. We illustrate our approach for transport through a single-level quantum dot and a metallic single-electron transistor to second order in the tunnel-coupling strength, and discuss under which circumstances non-Markovian effects appear in the transport properties.Comment: 4 pages, 2 figures, LaTeX; typos added, references adde

The PEP Survey: Infrared Properties of Radio-Selected AGN

By exploiting the VLA-COSMOS and the Herschel-PEP surveys, we investigate the Far Infrared (FIR) properties of radio-selected AGN. To this purpose, from VLA-COSMOS we considered the 1537, F[1.4 GHz]>0.06 mJy sources with a reliable redshift estimate, and sub-divided them into star-forming galaxies and AGN solely on the basis of their radio luminosity. The AGN sample is complete with respect to radio selection at all z<~3.5. 832 radio sources have a counterpart in the PEP catalogue. 175 are AGN. Their redshift distribution closely resembles that of the total radio-selected AGN population, and exhibits two marked peaks at z~0.9 and z~2.5. We find that the probability for a radio-selected AGN to be detected at FIR wavelengths is both a function of radio power and redshift, whereby powerful sources are more likely to be FIR emitters at earlier epochs. This is due to two distinct effects: 1) at all radio luminosities, FIR activity monotonically increases with look-back time and 2) radio activity of AGN origin is increasingly less effective at inhibiting FIR emission. Radio-selected AGN with FIR emission are preferentially located in galaxies which are smaller than those hosting FIR-inactive sources. Furthermore, at all z<~2, there seems to be a preferential (stellar) mass scale M ~[10^{10}-10^{11}] Msun which maximizes the chances for FIR emission. We find such FIR (and MIR) emission to be due to processes indistinguishable from those which power star-forming galaxies. It follows that radio emission in at least 35% of the entire AGN population is the sum of two contributions: AGN accretion and star-forming processes within the host galaxy.Comment: 13 pages, 14 figures, to appear in MNRA

Geometric picture of quantum discord for two-qubit quantum states

Among various definitions of quantum correlations, quantum discord has attracted considerable attention. To find analytical expression of quantum discord is an intractable task. Exact results are known only for very special states, namely, two-qubit X-shaped states. We present in this paper a geometric viewpoint, from which two-qubit quantum discord can be described clearly. The known results about X state discord are restated in the directly perceivable geometric language. As a consequence, the dynamics of classical correlations and quantum discord for an X state in the presence of decoherence is endowed with geometric interpretation. More importantly, we extend the geometric method to the case of more general states, for which numerical as well as analytica results about quantum discord have not been found yet. Based on the support of numerical computations, some conjectures are proposed to help us establish geometric picture. We find that the geometric picture for these states has intimate relationship with that for X states. Thereby in some cases analytical expressions of classical correlations and quantum discord can be obtained.Comment: 9 figure