The effect of potential supramolecular-bond promoters on the DNA-interacting abilities of copper-terpyridine compounds.

Three copper(II) coordination compounds have been prepared from three different 2,2′:6′,2′′-terpyridine-based ligands, which have been selected to investigate the potential role of supramolecular interactions on the DNA-interacting and cytotoxicity properties of the corresponding metal complexes. Hence, the ligands 4′-((naphthalen-2-yl)methoxy)-2,2′:6′,2′′-terpyridine (Naphtpy) and 4′-((1H-benzo[d]imidazol-2-yl)methoxy)-2,2′:6′,2′′-terpyridine (Bimztpy) have been synthesized from commercially-available 4′-chloro-2,2′:6′,2′′-terpyridine (Cltpy), and their copper(II) complexes have been obtained by reaction with copper(II) nitrate. The DNA-interacting abilities of the corresponding compounds [Cu(Cltpy)(H2O)(NO3)2] (1), [Cu(naphtpy)(NO3)(H2O)](NO3)(MeOH) (2) and [Cu(bimztpy)(NO3)(H2O)](NO3) (3) have been investigated using different techniques, and cytotoxicity assays with several cancer cell lines have revealed interesting features, viz. the more efficient complex is 2, which although it does not act as a DNA cleaver, displays the most effective DNA-interacting and cytotoxic properties, compared to 1 and 3

Assessment and nutrition education in patients with amyotrophic lateral sclerosis

ABSTRACT Neurological patients with amyotrophic lateral sclerosis (ALS)often deteriorate to a worsening nutritional status. The aim of this study was to compare the nutritional status and food intake after nutrition education in patients with ALS. Clinical, anthropometric and functional variables were analyzed. Fifty-three patients were monitored at an early stage of the disease. The average score on the functionality scale was 33 points. Initially only 3.8% were classified as low body weight. After three months, 50% showed significant variation in anthropometric measures related to muscle mass and body fat reserves without association with clinical variables. After nutritional guidance, there was an increase in the intake of all food groups, especially the dairy group (p <0.05).The change of the nutritional status occurs early in patients with amyotrophic lateral sclerosis, even in those previously eutrophic or over weight. There was an increase in food intake after nutritional guidance according to the food guide adapted to the Brazilian population

The effect of potential supramolecular-bond promoters on the DNA-interacting abilities of copper-terpyridine compounds.

Three copper(II) coordination compounds have been prepared from three different 2,2′:6′,2′′-terpyridine-based ligands, which have been selected to investigate the potential role of supramolecular interactions on the DNA-interacting and cytotoxicity properties of the corresponding metal complexes. Hence, the ligands 4′-((naphthalen-2-yl)methoxy)-2,2′:6′,2′′-terpyridine (Naphtpy) and 4′-((1H-benzo[d]imidazol-2-yl)methoxy)-2,2′:6′,2′′-terpyridine (Bimztpy) have been synthesized from commercially-available 4′-chloro-2,2′:6′,2′′-terpyridine (Cltpy), and their copper(II) complexes have been obtained by reaction with copper(II) nitrate. The DNA-interacting abilities of the corresponding compounds [Cu(Cltpy)(H2O)(NO3)2] (1), [Cu(naphtpy)(NO3)(H2O)](NO3)(MeOH) (2) and [Cu(bimztpy)(NO3)(H2O)](NO3) (3) have been investigated using different techniques, and cytotoxicity assays with several cancer cell lines have revealed interesting features, viz. the more efficient complex is 2, which although it does not act as a DNA cleaver, displays the most effective DNA-interacting and cytotoxic properties, compared to 1 and 3

Formation, Structure, and Morphology of Triazole-Based Langmuir-Blodgett Films

The formation, morphology, and structure of two-dimensional Langmuir-Blodgett (LB) assemblies of octadecyltriazole (ODT)-based metal-containing oligomers presenting, in the case of iron, the spin-crossover phenomenon is studied with Brewster angle microscopy, IR dichroism, X-ray diffraction, and atomic force microscopy. Two processes occurring at the air-water interface are confirmed to dominate the mechanism of formation of these LB films, the instability of the coordination polymers at the air-water interface and recoordination of metal ions in the subphase at the interface during the LB deposition process. The Langmuir film allowing the LB film formation is mostly made of ODT. The films do present a lamellar structure in which the ODT molecules are tilted and incorporate coordinated isolated metal ions and oligomers of metal ions. The morphology of the LB films is globally flat but with a rather high roughness resulting from inhomogeneities related to phenomena occurring during the LB film formation. These observations are in agreement with the relative affinity of the metal ions with ODT and the relative stability of the coordination polymers at the air-water interface, which have been determined for the group Cu-Fe-Co-Ni

Comment réduire les dysphonies parkinsoniennes par thyroplastie

International audienceL’hypophonie joue un rôle important sur la qualité de la communication orale des patients parkinsoniens en majorant les effets de la dysarthrie associée. Lorsque cette hypophonie est liée à un défaut d’adduction des cordes vocales, constituant ainsi une « incompétence laryngée », une médialisation d’une corde vocale peut être proposée en cas d’échec de la prise en charge rééducative. Des techniques d’analyses acoustique et aérodynamique de la voix et de la parole, d’évaluation perceptive et d’estimation du handicap vocal, associées à une fibroscopie laryngée ont été réalisées pour discuter de l’indication de médialisation laryngée dans ces incompétences laryngées. Une médialisation d’une corde vocale par thyroplastie (implant de Montgomery), sous anesthésie locale et neuroanalgésie, a été réalisée chez deux patients parkinsoniens avec une dysphonie réfractaire à la rééducation. Après l’intervention, une réévaluation des différents paramètres a montré un enrichissement du timbre via l’accroissement du nombre d’harmoniques et une amélioration des paramètres aérodynamiques. La médialisation d’une corde vocale, en réduisant l’hypophonie par une meilleure adduction glottique, a amélioré efficacement la voix et le confort de communication orale de ces deux patients. La technique de médialisation par thyroplastie, sous anesthésie locale, permet un contrôle peropératoire de la voix mais aussi le retrait potentiel de l’implant

Formation, Structure, and Morphology of Triazole-Based Langmuir−Blodgett Films

The formation, morphology, and structure of two-dimensional Langmuir−Blodgett (LB) assemblies of octadecyltriazole (ODT)-based metal-containing oligomers presenting, in the case of iron, the spin-crossover phenomenon is studied with Brewster angle microscopy, IR dichroism, X-ray diffraction, and atomic force microscopy. Two processes occurring at the air−water interface are confirmed to dominate the mechanism of formation of these LB films, the instability of the coordination polymers at the air−water interface and recoordination of metal ions in the subphase at the interface during the LB deposition process. The Langmuir film allowing the LB film formation is mostly made of ODT. The films do present a lamellar structure in which the ODT molecules are tilted and incorporate coordinated isolated metal ions and oligomers of metal ions. The morphology of the LB films is globally flat but with a rather high roughness resulting from inhomogeneities related to phenomena occurring during the LB film formation. These observations are in agreement with the relative affinity of the metal ions with ODT and the relative stability of the coordination polymers at the air−water interface, which have been determined for the group Cu−Fe−Co−Ni