Linking cause assessment, corporate philanthropy, and corporate reputation

This study analyzes the link between cause assessment, corporate philanthropy, and dimensions of corporate reputation from different stakeholders' perspectives, using balance theory as a conceptual framework and the telecommunications industry in Austria and Egypt as the empirical setting. Findings show that corporate philanthropy can improve perceptions of the corporate reputation dimensions, but the results vary between customers and non-customers and depend on the country setting

Design of Electromagnetic Cloaks and Concentrators Using Form-Invariant Coordinate Transformations of Maxwell's Equations

The technique of applying form-invariant, spatial coordinate transformations of Maxwell's equations can facilitate the design of structures with unique electromagnetic or optical functionality. Here, we illustrate the transformation-optical approach in the designs of a square electromagnetic cloak and an omni-directional electromagnetic field concentrator. The transformation equations are described and the functionality of the devices is numerically confirmed by two-dimensional finite element simulations. The two devices presented demonstrate that the transformation optic approach leads to the specification of complex, anisotropic and inhomogeneous materials with well directed and distinct electromagnetic behavior.Comment: submitted to "Photonics and Nanostructures", Special Issue "PECS VII", Elsevie

Structural Test and Analysis of a Hybrid Inflatable Antenna

NASA is developing ultra-lightweight structures technology for communication antennas for space missions. One of the research goals is to evaluate the structural characteristics of inflatable and rigidizable antennas through test and analysis. Being able to test and analyze the structural characteristics of a full scale antenna is important to enable the simulation of various mission scenarios to determine system performance in space. Recent work completed to evaluate a Hybrid Inflatable Antenna concept will be discussed. Tests were completed on a 2-m prototype to optimize its static shape and identify its modal dynamics that are important for analytical model validation. These test results were used to evaluate a preliminary finite element model of the antenna, and this model development and correlation activity is also described in the paper

An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors.

To address the biological heterogeneity of lung cancer, we studied 199 lung adenocarcinomas by integrating genome-wide data on copy number alterations and gene expression with full annotation for major known somatic mutations in this cancer. This showed non-random patterns of copy number alterations significantly linked to EGFR and KRAS mutation status and to distinct clinical outcomes, and led to the discovery of a striking association of EGFR mutations with underexpression of DUSP4, a gene within a broad region of frequent single-copy loss on 8p. DUSP4 is involved in negative feedback control of EGFR signaling, and we provide functional validation for its role as a growth suppressor in EGFR-mutant lung adenocarcinoma. DUSP4 loss also associates with p16/CDKN2A deletion and defines a distinct clinical subset of lung cancer patients. Another novel observation is that of a reciprocal relationship between EGFR and LKB1 mutations. These results highlight the power of integrated genomics to identify candidate driver genes within recurrent broad regions of copy number alteration and to delineate distinct oncogenetic pathways in genetically complex common epithelial cancers

Under-representation of males in the early years: the challenges leaders face

This article investigates why there appears to be an under-representation of males in comparison to their female colleagues in the Early Years (EY) sector, and the perception of male teachers progressing more quickly to leadership positions when they do enter this context. Using case studies of final year male students on an Initial Teacher Training (ITT) undergraduate degree course at one university, we attempt to analyse data on male under-representation in Early Years against contemporary theories of identity, power and leadership. Questionnaires and interviews were conducted with the male sample group and male senior leaders in primary schools to gain an overview as to the leadership support they needed and provided. Our tentative findings suggested that male trainees are happy to work in an Early Years context and take leadership positions, but the challenge for leaders is that male trainees require strong leadership mentoring processes to help overcome perceived contextual barriers

Quadrupole collective modes in trapped finite-temperature Bose-Einstein condensates

Finite temperature simulations are used to study quadrupole excitations of a trapped Bose-Einstein condensate. We focus specifically on the m=0 mode, where a long-standing theoretical problem has been to account for an anomalous variation of the mode frequency with temperature. We explain this behavior in terms of the excitation of two separate modes, corresponding to coupled motion of the condensate and thermal cloud. The relative amplitudes of the modes depends sensitively on the temperature and on the frequency of the harmonic drive used to excite them. Good agreement with experiment is found for appropriate drive frequencies.Comment: 4 pages, 3 figure

A technological organization analysis of Paleoamerican occupation, adaptation, and settlement at the Potter Site in the White Mountains of New Hampshire

In the New England Maritimes region, and especially New Hampshire, small lithic sites or scatters represent the most prevalent Paleoamerican site type identified on the landscape in the course of cultural resource management (CRM) and research activities. Correspondingly, distributed across this same landscape are a considerably far fewer number of significant large sites. Several different functional interpretations have been ascribed to these larger sites; all based on some version of the assumption that the large sites are accumulations of individual small sites either by aggregation or sequential visits. On present-day route 2 in the Moose River valley of the state of New Hampshire, a Paleoamerican site is situated with an area of 2 ½ acres, 11 excavation units (1m x 1m or greater) and containing approximately 15,900 lithic artifacts, that is known as the Potter site. This attribute depiction suggests similarities between Potter and the few other large regional sites broadly associated with the Vail/Debert and Gainey/Bull Brook time horizons or more specifically; Bull Brook, Whipple, Nobles Pond, Debert, Dedic/Sugarloaf, and Vail. These regional sites manifest in terms of the significant number of “hotspots” or loci, the rarity of its large size, earliest fluted point styles, low number of lithic material sources, rich artifact assemblages, site positioning overlooking a remnant of a glacial pond, and a chokepoint topography. The research question addressed in this doctoral thesis is: was Potter a single large seasonal hunting aggregation, single occupation marshaling event, seasonal episodic reuse interpretation or alternatively, a seasonal social aggregation site type, or perhaps something altogether different? The goal of this study was to evaluate the Potter site’s inhabitant’s lifeways, using flaked stone tool analysis modeling, in contrast to the rare number of large sites types identified regionally and to determine a response to the question; what kind of a site was Potter? Also, while in doing so, increasing the current understanding of the range of Paleoamerican horizon adaptations in the White Mountains of New Hampshire. Quantitative and qualitative, or more specifically formal and informal heuristic lithic analysis methods, were applied to the excavated site flake stone tool and debitage artifact assemblage to determine a response to the research questions. Each site locus was individually evaluated to infer behavior traits that comprise the site’s overall activities and settlement patterns yielding the interpretation of Potter as a seasonal episodic reuse site

Safety, tolerability, and impact on allergic inflammation of autologous E.coli autovaccine in the treatment of house dust mite asthma - a prospective open clinical trial

Background: Asthma is increasing worldwide and results from a complex immunological interaction between genetic susceptibility and environmental factors. Autovaccination with E. coli induces a strong TH-1 immune response, thus offering an option for the treatment of allergic diseases. Methods: Prospective open trial on safety, tolerability, and impact on allergic inflammation of an autologous E.coli autovaccine in intermittent or mild persistent house dust mite asthma. Determination of exhaled nitric monoxide (eNO) before and after bronchial mite challenge initially and after nine months of autovaccination. Results: Median eNO increase after autovaccination was significantly smaller (from 27.3 to 33.8 ppb; p=0.334) compared to initial values (from 32.6 to 42.2 ppb; p=0.046) (p=0.034). In nine subjects and a total of 306 injections, we observed 101 episodes of local erythema (33.3%; median of maximal diameter 2.5 cm), 95 episodes of local swelling (31.1%; median of maximal diameter 3 cm), and 27 episodes of local pain (8.8%). Four subjects reported itching at the injection site with a total of 30 episodes (9.8%). We observed no serious adverse events. All organ functions (inclusive electrocardiogramm) and laboratory testing of the blood (clinical chemistry, hematology) and the urine (screening test, B-microglobuline) were within normal limits. Vital signs undulated within the physiological variability. Conclusion: The administration of autologous autovacine for the treatment of house dust mite asthma resulted in a reduction of the eNO increase upon bronchial mite challenge. In nine subjects and 306 injections, only a few mild local reactions and no systemic severe adverse events were observed. EudraCT Nr. 2005-005534-12 ClinicalTrials.gov ID NCT0067720

Dual regulation by microRNA-200b-3p and microRNA-200b-5p in the inhibition of epithelial-to-mesenchymal transition in triple-negative breast cancer

Epithelial to mesenchymal transition (EMT) involves loss of an epithelial phenotype and activation of a mesenchymal one. Enhanced expression of genes associated with a mesenchymal transition includes ZEB1/2, TWIST, and FOXC1. miRNAs are known regulators of gene expression and altered miRNA expression is known to enhance EMT in breast cancer. Here we demonstrate that the tumor suppressive miRNA family, miR-200, is not expressed in triple negative breast cancer (TNBC) cell lines and that miR-200b-3p over-expression represses EMT, which is evident through decreased migration and increased CDH1 expression. Despite the loss of migratory capacity following re-expression of miR-200b-3p, no subsequent loss of the conventional miR-200 family targets and EMT markers ZEB1/2 was observed. Next generation RNA-sequencing analysis showed that enhanced expression of pri-miR-200b lead to ectopic expression of both miR-200b-3p and miR-200b-5p with multiple isomiRs expressed for each of these miRNAs. Furthermore, miR-200b-5p was expressed in the receptor positive, epithelial breast cancer cell lines but not in the TNBC (mesenchymal) cell lines. In addition, a compensatory mechanism for miR-200b-3p/200b-5p targeting, where both miRNAs target the RHOGDI pathway leading to non-canonical repression of EMT, was demonstrated. Collectively, these data are the first to demonstrate dual targeting by miR-200b-3p and miR-200b-5p and a previously undescribed role for microRNA processing and strand expression in EMT and TNBC, the most aggressive breast cancer subtype

The "Buruli Score": development of a multivariable prediction model for diagnosis of Mycobacterium ulcerans infection in individuals with ulcerative skin lesions, Akonolinga, Cameroon

Background Access to laboratory diagnosis can be a challenge for individuals suspected of Buruli Ulcer (BU). Our objective was to develop a clinical score to assist clinicians working in resource- limited settings for BU diagnosis. Methododology/Principal Findings Between 2011 and 2013, individuals presenting at Akonolinga District Hospital, Cameroon, were enrolled consecutively. Clinical data were collected prospectively. Based on a latent class model using laboratory test results (ZN, PCR, culture), patients were categorized into high, or low BU likelihood. Variables associated with a high BU likelihood in a multivariate logistic model were included in the Buruli score. Score cut-offs were chosen based on calculated predictive values. Of 325 patients with an ulcerative lesion, 51 (15.7%) had a high BU likelihood. The variables identified for the Buruli score were: characteristic smell (+3 points), yellow color (+2), female gender (+2), undermining (+1), green color (+1), lesion hyposensitivity (+1), pain at rest (-1), size >5cm (-1), locoregional adenopathy (-2), age above 20 up to 40 years (-3), or above 40 (-5). This score had AUC of 0.86 (95% CI 0.82-0.89), indicating good discrimination between infected and non-infected individuals. The cut-off to reasonably exclude BU was set at scores = 4 (PPV 69.0%; 95% CI 49.2-84.7). Patients with intermediate BU probability needed to be tested by PCR. Conclusions/Significance We developed a decisional algorithm based on a clinical score assessing BU probability. The Buruli score still requires further validation before it can be recommended for wide use