Applications of airborne remote sensing in atmospheric sciences research

This paper explores the potential for airborne remote sensing for atmospheric sciences research. Passive and active techniques from the microwave to visible bands are discussed. It is concluded that technology has progressed sufficiently in several areas that the time is right to develop and operate new remote sensing instruments for use by the community of atmospheric scientists as general purpose tools. Promising candidates include Doppler radar and lidar, infrared short range radiometry, and microwave radiometry

Augmented Exercise Biking with Virtual Environments for Elderly Users:Considerations on the use of auditory feedback

Virtual reality (VR) has been shown to function well as an assistive technology to physical therapy for elderly users. Elderly users, and more specifically retirement home residents, form a unique user group in this field, due to their characteristics and demands. In a case study, retirement home residents used an audio-visual virtual environment (VE) augmentation for an exercise bike. Besides a visual display, a soundscape was played to the subjects using headphones. The soundscape was not no- ticed wand the headphones were found to be obtrusive. In this paper, we consider and discuss possible approaches to alternative auditory and haptic delivery methods for future studies. These nonvisual displays need to fit the requirements and limitations of the retirement home subjects who are to exercise using the VE-based augmenta- tion from the case study

Do adults with high functioning autism or Asperger Syndrome differ in empathy and emotion recognition?

The present study examined whether adults with high functioning autism (HFA) showed greater difficulties in (i) their self-reported ability to empathise with others and/or (ii) their ability to read mental states in others’ eyes than adults with Asperger syndrome (AS). The Empathy Quotient (EQ) and ‘Reading the Mind in the Eyes’ Test (Eyes Test) were compared in 43 adults with AS and 43 adults with HFA. No significant difference was observed on EQ score between groups, while adults with AS performed significantly better on the Eyes Test than those with HFA. This suggests that adults with HFA may need more support, particularly in mentalizing and complex emotion recognition, and raises questions about the existence of subgroups within autism spectrum conditions

Physical properties of FeSe0.5_{0.5}Te0.5_{0.5} single crystals grown under different conditions

We report on structural, magnetic, conductivity, and thermodynamic studies of FeSe$_{0.5}$Te$_{0.5}$ single crystals grown by self-flux and Bridgman methods. The samples were prepared from starting materials of different purity at various temperatures and cooling rates. The lowest values of the susceptibility in the normal state, the highest transition temperature $T_c$ of 14.5 K, and the largest heat-capacity anomaly at $T_c$ were obtained for pure (oxygen-free) samples. The critical current density $j_c$ of $8 \times 10^4$ A/cm$^2$ (at 2 K) achieved in pure samples is attributed to intrinsic inhomogeneity due to disorder at the cation and anion sites. The impure samples show increased $j_c$ up to $2.3 \times 10^5$ A/cm$^2$ due to additional pinning centers of Fe$_3$O$_4$. The upper critical field $H_{c2}$ of $\sim 500$ kOe is estimated from the resistivity study in magnetic fields parallel to the \emph{c}-axis. The anisotropy of the upper critical field $\gamma_{H_{c2}} = H_{_{c2}}^{ab}/H_{_{c2}}^{c}$ reaches a value $\sim 6$ at $T\longrightarrow T_c$. Extremely low values of the residual Sommerfeld coefficient for pure samples indicate a high volume fraction of the superconducting phase (up to 97%). The electronic contribution to the specific heat in the superconducting state is well described within a single-band BCS model with a temperature dependent gap $\Delta_0 = 27(1)$ K. A broad cusp-like anomaly in the electronic specific heat of samples with suppressed bulk superconductivity is ascribed to a splitting of the ground state of the interstitial Fe$^{2+}$ ions. This contribution is fully suppressed in the ordered state in samples with bulk superconductivity.Comment: 11 pages, 11 figures, 3 table

Do grade II ankle sprains have chronic effects on the functional ability of ballet dancers performing single-leg flat-foot stance? An observational cross-sectional study

Ballet dancers have a higher risk than the general population of ankle sprains. Ankle proprioception is of the utmost importance for executing static and dynamic positions typical of ballet dancing. Ankle sprains can create changes in functional ability that may affect ballet performance. The aim of this cross-sectional observational study is to evaluate if non-professional ballet dancers that were previously injured with a grade II ankle sprain carry a long-term stability deficit in ballet specific positions (pass\ue9, arabesque) and in single-leg flat-foot stance, thereby affecting ballet performance. We enrolled 22 amateur female ballet dancers, 11 who previously had a grade II ankle injury and 11 who had no history of ankle injury. Stabilometric data (Center of Pressure Speed and Elipse Area) were assessed with the postural electronic multisensory baropodometer in normal, arabesque, and pass\ue8 positions with both open and closed eyes. Using an unpaired t-test, we compared healthy and pathological feet of the ankle injury group for a standard monopodalic position and two ballet-specific positions. No difference between pathological and healthy feet of non-professional ballet dancers who suffered grade II ankle injury was detected. According to the parameters considered in this study, grade II ankle sprains seem to have a favorable prognosis in the sample that we evaluated

Specific Heat Discontinuity, deltaC, at Tc in BaFe2(As0.7P0.3)2 - Consistent with Unconventional Superconductivity

We report the specific heat discontinuity, deltaC/Tc, at Tc = 28.2 K of a collage of single crystals of BaFe2(As0.7P0.3)2 and compare the measured value of 38.5 mJ/molK**2 with other iron pnictide and iron chalcogenide (FePn/Ch) superconductors. This value agrees well with the trend established by Bud'ko, Ni and Canfield who found that deltaC/Tc ~ a*Tc**2 for 14 examples of doped Ba1-xKxFe2As2 and BaFe2-xTMxAs2, where the transition metal TM=Co and Ni. We extend their analysis to include all the FePn/Ch superconductors for which deltaC/Tc is currently known and find deltaC/Tc ~ a*Tc**1.9 and a=0.083 mJ/molK**4. A comparison with the elemental superconductors with Tc>1 K and with A-15 superconductors shows that, contrary to the FePn/Ch superconductors, electron-phonon-coupled conventional superconductors exhibit a significantly different dependence of deltaC on Tc, namely deltaC/Tc ~ Tc**0.9. However deltaC/gamma*Tc appears to be comparable in all three classes (FePn/Ch, elemental and A-15) of superconductors with, e. g., deltaC/gamma*Tc=2.4 for BaFe2(As0.7P0.3)2. A discussion of the possible implications of these phenomenological comparisons for the unconventional superconductivity believed to exist in the FePn/Ch is given.Comment: some disagreement in reference and footnote numbering with the published versio

Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal

Activation of tissue mast cells (MCs) and their abnormal growth and accumulation in various organs are typically found in primary MC disorders also referred to as mastocytosis. However, increasing numbers of patients are now being informed that their clinical findings are due to MC activation (MCA) that is neither associated with mastocytosis nor with a defined allergic or inflammatory reaction. In other patients with MCA, MCs appear to be clonal cells, but criteria for diagnosing mastocytosis are not met. A working conference was organized in 2010 with the aim to define criteria for diagnosing MCA and related disorders, and to propose a global unifying classification of all MC disorders and pathologic MC reactions. This classification includes three types of `MCA syndromes' (MCASs), namely primary MCAS, secondary MCAS and idiopathic MCAS. MCA is now defined by robust and generally applicable criteria, including (1) typical clinical symptoms, (2) a substantial transient increase in serum total tryptase level or an increase in other MC-derived mediators, such as histamine or prostaglandin D 2, or their urinary metabolites, and (3) a response of clinical symptoms to agents that attenuate the production or activities of MC mediators. These criteria should assist in the identification and diagnosis of patients with MCAS, and in avoiding misdiagnoses or overinterpretation of clinical symptoms in daily practice. Moreover, the MCAS concept should stimulate research in order to identify and exploit new molecular mechanisms and therapeutic targets. Copyright (C) 2011 S. Karger AG, Base

Novel approach to three-dimensional intermaxillary skeletal assessment

Purpose: The present study aimed to compare and correlate the ANB angle with the bisector Wits appraisal for a three-dimensional (3D) assessment of the maxillomandibular sagittal relationship using a cone beam computed tomography (CBCT) dataset. Methods: After outlier removal, 351 CBCT scans were chosen based on inclusion criteria (high quality, full-cranium field of view [FOV], slice thickness 150–300 μm) and analyzed using 3DSlicer software (Brigham and Women’s Hospital, Boston, MA, USA, version 5.2.2). Eight anatomical landmarks were manually annotated, identified on axial views, and confirmed on the rendered volume image. The coordinates of each landmark were exported and the ANB (°) and bisector–Wits (mm) measurements were constructed. Dahlberg’s D tested the intraobserver reliability and two-sample Kolmogorov–Smirnov test was executed to assess normality and to select the subsequent tests. Spearman’s rank correlation coefficient (ρ) was utilized to correlate the angular (ANB) and linear (bisector–Wits) measurements, whereas the Siegel estimator for nonparametric linear regression was employed to establish norm values by the correlation equation. Significance was set at p < 0.05 with correlation coefficients exceeding ρ > 0.70 deemed clinically relevant. Results: High (ρ = 0.773) and statistically significant (p < 0.001) correlations between the ANB and bisector–Wits measurements were found. The obtained equation was the following: bisector–Wits = 1.06 × ANB – 6.32. Therefore, the obtained rounded norm range for bisector–Wits for skeletal class I sagittal relationship was determined to be from −6.3 to −2.1 mm (−4.2 ± 2.1 mm). Values less than −6.3 mm correspond to a class III, whereas greater than −2.1 mm correspond to a class II skeletal relationship. Conclusion: The study revealed a statistically significant correlation between the ANB and bisector–Wits. From a 3D perspective, the bisector–Wits represents a reliable parameter to assess maxilla–mandibular skeletal discrepancies instead of the ANB angle, also adhering to radioprotection principles by limiting the FOV to the maxillary complex only and potentially reducing the radiation exposure in CBCT-based cephalometry

Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design

β-Secretase (BACE1), the enzyme responsible for the first and rate-limiting step in the production of amyloid-β peptides, is an attractive target for the treatment of Alzheimer’s disease. In this study, we report the application of the de novo fragment-based molecular design program SPROUT to the discovery of a series of nonpeptide BACE1 inhibitors based upon a biphenylacetamide scaffold. The binding affinity of molecules based upon this designed molecular scaffold was increased from an initial BACE1 IC50 of 323 μM to 27 μM following the synthesis of a library of optimized ligands whose structures were refined using the recently developed SPROUT-HitOpt software. Although a number of inhibitors were found to exhibit cellular toxicity, one compound in the series was found to have useful BACE1 inhibitory activity in a cellular assay with minimal cellular toxicity. This work demonstrates the power of an in silico fragment-based molecular design approach in the discovery of novel BACE1 inhibitors