A Review of Biotechnological Artemisinin Production in Plants

Malaria is still an eminent threat to major parts of the world population mainly in sub-Saharan Africa. Researchers around the world continuously seek novel solutions to either eliminate or treat the disease. Artemisinin, isolated from the Chinese medicinal herb Artemisia annua, is the active ingredient in artemisinin-based combination therapies used to treat the disease. However, naturally artemisinin is produced in small quantities, which leads to a shortage of global supply. Due to its complex structure, it is difficult chemically synthesize. Thus to date, A. annua remains as the main commercial source of artemisinin. Current advances in genetic and metabolic engineering drives to more diverse approaches and developments on improving in planta production of artemisinin, both in A. annua and in other plants. In this review, we describe efforts in bioengineering to obtain a higher production of artemisinin in A. annua and stable heterologous in planta systems. The current progress and advancements provides hope for significantly improved production in plants

A multiscale view on inverse statistics and gain/loss asymmetry in financial time series

Researchers have studied the first passage time of financial time series and observed that the smallest time interval needed for a stock index to move a given distance is typically shorter for negative than for positive price movements. The same is not observed for the index constituents, the individual stocks. We use the discrete wavelet transform to illustrate that this is a long rather than short time scale phenomenon -- if enough low frequency content of the price process is removed, the asymmetry disappears. We also propose a new model, which explain the asymmetry by prolonged, correlated down movements of individual stocks

Metal Enrichment of the Intergalactic Medium in Cosmological Simulations

Observations have established that the diffuse intergalactic medium (IGM) at z ~ 3 is enriched to ~0.1-1% solar metallicity and that the hot gas in large clusters of galaxies (ICM) is enriched to 1/3-1/2 solar metallicity at z=0. Metals in the IGM may have been removed from galaxies (in which they presumably form) during dynamical encounters between galaxies, by ram-pressure stripping, by supernova-driven winds, or as radiation-pressure driven dust efflux. This study develops a method of investigating the chemical enrichment of the IGM and of galaxies, using already completed cosmological simulations. To these simulations, we add dust and (gaseous) metals, distributing the dust and metals in the gas according to three simple parameterized prescriptions, one for each enrichment mechanism. These prescriptions are formulated to capture the basic ejection physics, and calibrated when possible with empirical data. Our results indicate that dynamical removal of metals from >~ 3*10^8 solar mass galaxies cannot account for the observed metallicity of low-column density Ly-alpha absorbers, and that dynamical removal from >~ 3*10^10 solar mass galaxies cannot account for the ICM metallicities. Dynamical removal also fails to produce a strong enough mass-metallicity relation in galaxies. In contrast, either wind or radiation-pressure ejection of metals from relatively large galaxies can plausibly account for all three sets of observations (though it is unclear whether metals can be distributed uniformly enough in the low-density regions without overly disturbing the IGM, and whether clusters can be enriched quite as much as observed). We investigate in detail how our results change with variations in our assumed parameters, and how results for the different ejection processes compare. (Abridged)Comment: Minor revision, 1 figure added addressing diffusion of metals after their ejection. Accepted by ApJ. 31 EmulateApj Pages with 13 embedded postscript figure

Concepts for manned lunar habitats

The design philosophy that will guide the design of early lunar habitats will be based on a compromise between the desired capabilities of the base and the economics of its development and implantation. Preferred design will be simple, make use of existing technologies, require the least amount of lunar surface preparation, and minimize crew activity. Three concepts for an initial habitat supporting a crew of four for 28 to 30 days are proposed. Two of these are based on using Space Station Freedom structural elements modified for use in a lunar-gravity environment. A third concept is proposed that is based on an earlier technology based on expandable modules. The expandable modules offer significant advantages in launch mass and packaged volume reductions. It appears feasible to design a transport spacecraft lander that, once landed, can serve as a habitat and a stand-off for supporting a regolith environmental shield. A permanent lunar base habitat supporting a crew of twelve for an indefinite period can be evolved by using multiple initial habitats. There appears to be no compelling need for an entirely different structure of larger volume and increased complexity of implantation

Course of Skin Symptoms and Quality of Life in Children Referred for Patch Testing - A Long-term Follow-up Study

Children are patch tested in the same manner as adults, but little has been done to establish whether positive or negative findings influence the course of skin symptoms. To uncover the course of skin symptoms and the impact of persistent eczema on life quality in paediatric patients referred for patch testing, a retrospective questionnaire was sent to children and adolescents referred for patch testing during a 9-year period. Persistent eczema at follow-up was strongly associated to atopic dermatitis, but was not explained by gender, age, contact allergy or time span from patch testing to follow-up. Among patients without atopic dermatitis, 23.5% reported to suffer from chronic eczema. Persistent eczema increased the risk of severe impairment of life quality. Our findings indicate a significant risk of childhood eczema becoming chronic and affecting life quality considerably. Patch testing did not affect the course of eczema, highlighting the difficulties of avoidance behaviour.</p