A search for rapid optical variability in radio-quiet quasars

The detection of rapid variability on a time-scale of hours in radio-quiet quasars (RQQSOs) could be a powerful discriminator between starburst, accretion disc and relativistic jet models of these sources. This paper contains an account of a dedicated search for rapid optical variability in RQQSOs. The technique used differential photometry between the RQQSO and stars in the same field of view of the CCD. The 23 RQQSOs that were observed all have high luminosities (-27 1. The total amount of observation time was about 60 hours and these observations are part of an ongoing programme, started in September 1990, to search for rapid variability in RQQSOs. No evidence for short-term variability greater than about 0.1 magnitudes was detected in any of the 23 sources, however long-term variability was recorded for the radio-quiet quasar PG 2112+059. The finding charts are included here because they identify the RQQSO and the reference stars used in the photometry, and hence are available for use by other observers.Comment: Accepted for publication in A&AS. 10 pages, 3 figures. Figure 1 (finding charts) available by anonymous ftp from: bermuda.ucd.ie:/pub/outgoing/charts.eps.g

Meta-model Pruning

Large and complex meta-models such as those of Uml and its profiles are growing due to modelling and inter-operability needs of numerous\ud stakeholders. The complexity of such meta-models has led to coining\ud of the term meta-muddle. Individual users often exercise only a small\ud view of a meta-muddle for tasks ranging from model creation to construction\ud of model transformations. What is the effective meta-model that represents\ud this view? We present a flexible meta-model pruning algorithm and\ud tool to extract effective meta-models from a meta-muddle. We use\ud the notion of model typing for meta-models to verify that the algorithm\ud generates a super-type of the large meta-model representing the meta-muddle.\ud This implies that all programs written using the effective meta-model\ud will work for the meta-muddle hence preserving backward compatibility.\ud All instances of the effective meta-model are also instances of the\ud meta-muddle. We illustrate how pruning the original Uml metamodel\ud produces different effective meta-models

Differential contribution of PB1-F2 to the virulence of highly pathogenic H5N1 influenza A virus in mammalian and avian species

Highly pathogenic avian influenza A viruses (HPAIV) of the H5N1 subtype occasionally transmit from birds to humans and can cause severe systemic infections in both hosts. PB1-F2 is an alternative translation product of the viral PB1 segment that was initially characterized as a pro-apoptotic mitochondrial viral pathogenicity factor. A full-length PB1-F2 has been present in all human influenza pandemic virus isolates of the 20(th) century, but appears to be lost evolutionarily over time as the new virus establishes itself and circulates in the human host. In contrast, the open reading frame (ORF) for PB1-F2 is exceptionally well-conserved in avian influenza virus isolates. Here we perform a comparative study to show for the first time that PB1-F2 is a pathogenicity determinant for HPAIV (A/Viet Nam/1203/2004, VN1203 (H5N1)) in both mammals and birds. In a mammalian host, the rare N66S polymorphism in PB1-F2 that was previously described to be associated with high lethality of the 1918 influenza A virus showed increased replication and virulence of a recombinant VN1203 H5N1 virus, while deletion of the entire PB1-F2 ORF had negligible effects. Interestingly, the N66S substituted virus efficiently invades the CNS and replicates in the brain of Mx+/+ mice. In ducks deletion of PB1-F2 clearly resulted in delayed onset of clinical symptoms and systemic spreading of virus, while variations at position 66 played only a minor role in pathogenesis. These data implicate PB1-F2 as an important pathogenicity factor in ducks independent of sequence variations at position 66. Our data could explain why PB1-F2 is conserved in avian influenza virus isolates and only impacts pathogenicity in mammals when containing certain amino acid motifs such as the rare N66S polymorphism

Evaluation of a multidisciplinary Tier 3 weight management service for adults with morbid obesity, or obesity and comorbidities, based in primary care

A multidisciplinary Tier 3 weight management service in primary care recruited patients with a body mass index ≥40 kg·m−2, or 30 kg·m−2 with obesity-related co-morbidity to a 1-year programme. A cohort of 230 participants was recruited and evaluated using the National Obesity Observatory Standard Evaluation Framework. The primary outcome was weight loss of at least 5% of baseline weight at 12 months. Diet was assessed using the two-item food frequency questionnaire, activity using the General Practice Physical Activity questionnaire and quality of life using the EuroQol-5D-5L questionnaire. A focus group explored the participants' experiences. Baseline mean weight was 124.4 kg and mean body mass index was 44.1 kg·m−2. A total of 102 participants achieved 5% weight loss at 12 months. The mean weight loss was 10.2 kg among the 117 participants who completed the 12-month programme. Baseline observation carried forward analysis gave a mean weight loss of 5.9 kg at 12 months. Fruit and vegetable intake, activity level and quality of life all improved. The dropout rate was 14.3% at 6 months and 45.1% at 1 year. Focus group participants described high levels of satisfaction. It was possible to deliver a Tier 3 weight management service for obese patients with complex co-morbidity in a primary care setting with a full multidisciplinary team, which obtained good health outcomes compared with existing services

Stimulated Raman spin coherence and spin-flip induced hole burning in charged GaAs quantum dots

High-resolution spectral hole burning (SHB) in coherent nondegenerate differential transmission spectroscopy discloses spin-trion dynamics in an ensemble of negatively charged quantum dots. In the Voigt geometry, stimulated Raman spin coherence gives rise to Stokes and anti-Stokes sidebands on top of the trion spectral hole. The prominent feature of an extremely narrow spike at zero detuning arises from spin population pulsation dynamics. These SHB features confirm coherent electron spin dynamics in charged dots, and the linewidths reveal spin spectral diffusion processes.Comment: 5 pages, 5 figure

Golden spiral photonic crystal fiber: polarization and dispersion properties

A golden spiral photonic crystal fiber (GS-PCF) design is presented in which air holes are arranged in a spiral pattern governed by the golden ratio, where the design has been inspired by the optimal arrangement of seeds found in nature. The birefringence and polarization properties of this fiber are analyzed using a vectorial finite-element method. The fiber that is investigated shows a large modal birefringence peak value of 0.016 at an operating wavelength of 1.55 μm and exhibits highly tuneable dispersion with multiple zero dispersion wavelengths and also large normal dispersion. The GS-PCF design has identical circular air holes that potentially simplify fabrication. In light of its properties, the GS-PCF could have application as a highly birefringent fiber and in nonlinear optics, and moreover the 2D chiral nature of the pattern could yield exotic properties